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56 条记录 (耗时 0.031 秒)

    MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF
    16.
    发明公开
    MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF 有权
    治疗性蛋白及其使用多聚体形式

    公开(公告)号：EP2542572A2

    公开(公告)日：2013-01-09

    申请号：EP11711151.8

    申请日：2011-03-02

    申请人： Protalix Ltd.

    发明人： RUDERFER, Ilya ,  SHILOVITTZKY, Orit ,  SHULMAN, Avidor ,  SHAALTIEL, Yoseph ,  BEN-MOSHE, Tehila ,  SHEKHTER, Talia ,  AZULAY, Yaniv

    IPC分类号： C07K14/525

    CPC分类号： C07K14/525

    摘要： Multimeric protein structures are disclosed herein, as well a process for preparing same, and methods employing same for treating various diseases or disorders. The multimeric protein structures comprise at least two monomers of a therapeutic protein, including a TNF-alpha, a luteinizing hormone, an immunoglobin, a TNF-alpha receptor, a CTLA-4, a urate oxidase, a VEGF, a PDGF, a VEGF receptor, a PDGF receptor, an interleukin-17, and/or fragments thereof, the monomers being covalently linked to one another via a linking moiety. The multimeric protein structures exhibit improved performance as compared to the corresponding native proteins, including a longer lasting activity in vivo.

    Mucosal or enteral administration of biologically active macromolecules
    17.
    发明公开
    Mucosal or enteral administration of biologically active macromolecules 有权
    MUKOSALE ODER ENTERALE VERABREICHUNG BIOLOGISCH AKTIVERMAKROMOLEKÜLE

    公开(公告)号：EP2441840A1

    公开(公告)日：2012-04-18

    申请号：EP11175326.5

    申请日：2006-07-18

    申请人： Protalix Ltd.

    发明人： Shaaltiel, Yoseph ,  Almon, Einat

    IPC分类号： C12N15/82 ,  A61K35/00

    CPC分类号： C12N15/8257 ,  C12N15/8258

    摘要： A unit dosage form for delivery of a biologically active recombinant biomolecule to a tissue of a subject, the unit dosage form comprising, a therapeutically effective amount of isolated plant cells of a BY2 cell line, said isolated plant cells expressing the recombinant biomolecule.

    摘要翻译： 用于将生物活性重组生物分子递送到受试者组织的单位剂型，所述单位剂型包含治疗有效量的BY2细胞系的分离的植物细胞，所述分离的表达重组生物分子的植物细胞。

    PRODUCTION OF HIGH MANNOSE PROTEINS IN PLANT CULTURE
    19.
    发明公开
    PRODUCTION OF HIGH MANNOSE PROTEINS IN PLANT CULTURE 审中-公开
    PFLANZENKULTUR ON ON ON UR UR UR UR UR UR UR UR UR UR UR UR

    公开(公告)号：EP2220105A2

    公开(公告)日：2010-08-25

    申请号：EP08738278.4

    申请日：2008-04-30

    申请人： Protalix Ltd.

    发明人： SHAALTIEL, Yoseph ,  BAUM, Gideon ,  BARTFELD, Daniel ,  HASHMUELI, Sharon ,  LEWKOWICZ, Ayala

    IPC分类号： C07H21/04 ,  C07K14/00

    CPC分类号： A61K38/47 ,  A61K9/0053 ,  A61K36/23 ,  C07K2319/04 ,  C12N9/2405 ,  C12N9/2434 ,  C12N9/2465 ,  C12N15/8257 ,  C12P21/005 ,  C12Y302/01022 ,  C12Y302/01045

    摘要： A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.

    摘要翻译： 用于在植物培养物中产生糖基化蛋白质的装置，系统和方法，特别是具有高甘露糖糖基化的蛋白质，同时用ER信号靶向这种蛋白质和/或旁路高尔基体。 本发明还涉及使用转基因植物根特别是胡萝卜细胞表达和产生酶促活性的高甘露糖溶酶体酶的载体和方法。 更具体地，本发明涉及宿主细胞，特别是转基因悬浮胡萝卜细胞，用于高产量表达和生产生物活性高甘露糖葡糖脑苷脂酶（GCD）的载体和方法。 本发明还提供了用于治疗溶酶体贮积病的组合物和方法。

    LARGE SCALE DISPOSABLE BIOREACTOR
    20.
    发明公开
    LARGE SCALE DISPOSABLE BIOREACTOR 有权
    GROSSTECHNISCHER EINWEG-BIOREAKTOR

    公开(公告)号：EP2150608A2

    公开(公告)日：2010-02-10

    申请号：EP08738315.4

    申请日：2008-05-05

    申请人： Protalix Ltd.

    发明人： SHAALTIEL, Yoseph ,  KIRSHNER, Yair ,  SHTAINIZ, Alon ,  NAOS, Yaron ,  SHNEOR, Yftach

    IPC分类号： C12M1/00 ,  C12M1/04 ,  C12M3/00

    CPC分类号： C12M41/34 ,  C12M23/00 ,  C12M23/26 ,  C12M23/28

    摘要： A reusable, disposable device for culturing plant tissues or cells including a non-rigid container having dimensions and gas exchange ports designed for maintaining oxygen saturation and shear forces suitable for culturing plant tissue or cells in 400 liters or more of culture medium is provided. Also provided are methods for producing a catalytically active human recombinant protein in a plant cell, using the disposable device of one of the embodiments of the instant specification.

    摘要翻译： 提供了一种用于培养植物组织或细胞的可重复使用的一次性装置，其包括具有尺寸的非刚性容器和设计用于维持适于培养400升或更多培养基中的植物组织或细胞的氧饱和度和剪切力的气体交换口。 还提供了使用本说明书的实施方案之一的一次性装置在植物细胞中产生催化活性的人重组蛋白的方法。