公开(公告)号：EP3125902A4

公开(公告)日：2018-01-24

申请号：EP15774070

申请日：2015-03-31

申请人： UNIV MARYLAND

发明人： THOMPSON SCOTT ,  KVARTA MARK D ,  VAN DYKE ADAM

IPC分类号： A61K31/55 ,  A61K31/515 ,  A61K31/56 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24

CPC分类号： A61K31/5517 ,  A61K31/4375 ,  A61K31/455 ,  A61K31/53 ,  A61K45/06

摘要： Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of GABAA receptors. In specific embodiments, depression and/or suicidability is treated or ameliorated or prevented with one or more negative modulators of GABAA receptors, such as a partial inverse agonist of a GABAA receptor comprising an alpha5 subunit.

公开(公告)号：EP3102199A4

公开(公告)日：2018-01-17

申请号：EP15740207

申请日：2015-01-21

申请人： UNIV JOHNS HOPKINS ,  UNIV MARYLAND

发明人： RASSOOL FEYRUZ ,  BAYLIN STEPHEN ,  ROBERT CARINE

IPC分类号： A61K31/341 ,  A61K31/4184 ,  A61K31/7068 ,  A61P35/00

CPC分类号： A61K31/706 ,  A61K31/145 ,  A61K31/166 ,  A61K31/4184 ,  A61K31/496 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/55 ,  A61K31/7068

摘要： The presently disclosed subject matter provides methods to treat cancer cells using low doses of DNA demethylating agents and poly ADP ribose polymerase (PARP) inhibitors. Methods also are provided for sensitizing a cell to a PARP inhibitor.

公开(公告)号：EP3125986A4

公开(公告)日：2017-11-15

申请号：EP15773730

申请日：2015-04-02

申请人： UNIV MARYLAND ,  UNIV OF MARYLAND BALTIMORE COUNTY

发明人： HONG LIYI ELLIOTT ,  CHOA FOW-SEN

IPC分类号： A61N1/00 ,  A61N2/00 ,  A61N2/08

CPC分类号： A61N2/006 ,  A61N1/40 ,  A61N2/02

摘要： The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain. The system is configured such that the DC magnetic fields may be used to manipulate the transient magnetic fields, in turn allowing significantly improved control and focus of the induced current within a specifically desired volume of interest within a patient's body.

公开(公告)号：EP3039422A4

公开(公告)日：2017-04-19

申请号：EP14841207

申请日：2014-09-02

申请人： UNIV MARYLAND ,  CHILDRENS NAT MEDICAL CT ,  US HEALTH

发明人： AYYUB OMAR BILAL ,  BEHRENS ADAM MICHAEL ,  KOFINAS PETER ,  SUMMAR MARSHALL LYNN ,  CABRERA-LUQUE JUAN MANUEL ,  CUNNINGHAM GARY ,  SIMEONOV ANTON ,  MARUGAN JUAN

IPC分类号： G01N33/00 ,  G01N33/84

CPC分类号： G01N33/4925 ,  G01N21/78 ,  G01N27/327 ,  G01N27/3275 ,  G01N33/6893 ,  G01N33/84 ,  G01N2800/04

摘要： The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.

公开(公告)号：EP2996470A4

公开(公告)日：2017-04-19

申请号：EP14797066

申请日：2014-05-16

申请人： UNIV MARYLAND

发明人： KHACHIK FREDERICK

IPC分类号： B01D11/02 ,  A23L5/44 ,  C07C403/24

CPC分类号： C07C29/84 ,  A23L5/44 ,  A23V2002/00 ,  A61K2236/00 ,  B01D9/00 ,  B01D11/0219 ,  B01D11/0296 ,  B01D2009/0086 ,  A23V2250/211

公开(公告)号：EP2991644A4

公开(公告)日：2017-02-08

申请号：EP14779540

申请日：2014-04-04

申请人： UNIV MARYLAND

发明人： NJAR VINCENT C O ,  PURUSHOTTAMACHAR PURANIK

IPC分类号： C07D235/04 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/4409 ,  A61K31/4725 ,  C07D235/08 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07J43/00

CPC分类号： A61K31/4725 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/4409 ,  C07D235/08 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07J43/003

摘要： Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.

摘要翻译： 非类固醇和类固醇化合物都引起雄激素受体（AR）的下调，这两种全长和剪接变体，诱导细胞凋亡和抑制增殖抑制和雄激素敏感性癌症细胞的迁移的增殖。 类固醇化合物和非类固醇化合物可以用于癌症的预防和/或治疗剂，包括前列腺癌，去势抗性前列腺癌，膀胱癌，胰腺癌，肝细胞癌，良性前列腺增生（BPH），肯尼迪氏病，雄激素性脱发， 乳房癌，雄激素不敏感综合征和脊髓和延髓性肌萎缩。

公开(公告)号：EP2973784A4

公开(公告)日：2016-11-30

申请号：EP14776172

申请日：2014-03-13

申请人： UNIV MARYLAND

发明人： WACHSMAN ERIC D ,  PAN KE-JI ,  GORE COLIN ,  JABBAR MOHAMMED HUSSAIN ABDUL ,  YOON HEE SUNG

IPC分类号： H01M4/00 ,  H01M4/90 ,  H01M8/12 ,  H01M8/124

CPC分类号： H01M4/9033 ,  H01M2008/1293 ,  Y02E60/50 ,  Y02E60/525

摘要： Novel anode materials including various compositions of vanadium-doped strontium titanate (SVT), and various compositions of vanadium- and sodium-doped strontium niobate (SNNV) for low- or intermediate-temperature solid oxide fuel cell (SOFCs). These materials offer high conductivity achievable at intermediate and low temperatures and can be used as the structural support of the SOFC anode and/or as the conductive phase of an anode. A method of making a low- or intermediate-temperature SOFC having an anode layer including SVT or SNNV is also provided.

公开(公告)号：EP2999427A4

公开(公告)日：2016-11-16

申请号：EP14800460

申请日：2014-05-21

申请人： UNIV NORTHWESTERN ,  UNIV MARYLAND ,  ANN AND ROBERT H LURIE CHILDREN S HOSPITAL OF CHICAGO

发明人： KAUSHAL SUNJAY ,  HO DEAN ,  ROBINSON ERIK M ,  MCCARTHY PATRICK M

IPC分类号： A61F2/00 ,  A61L31/06

CPC分类号： A61L31/16 ,  A61K9/7007 ,  A61K31/343 ,  A61K31/573 ,  A61L29/085 ,  A61L31/06 ,  A61L31/082 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/424 ,  A61L2300/45 ,  A61L2400/18 ,  A61L2430/20 ,  C08L65/04

摘要： The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.

公开(公告)号：EP2971279A4

公开(公告)日：2016-08-03

申请号：EP14763363

申请日：2014-03-14

申请人： UNIV PRINCETON ,  UNIV MARYLAND

发明人： D SILVA JOSEPH ,  AUSTIN ROBERT H ,  STURM JAMES C ,  CHEN YU ,  CIVIN CURT I

IPC分类号： B01L3/00 ,  G01N27/447 ,  G01N33/50

CPC分类号： G01N1/34 ,  A61K35/14 ,  A61K35/28 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1894 ,  B01L2400/086 ,  G01N15/1404 ,  G01N33/5094 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1493 ,  G01N2333/70596

摘要： Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.

公开(公告)号：EP2427769A4

公开(公告)日：2016-08-03

申请号：EP10772603

申请日：2010-04-29

申请人： UNIV MARYLAND

发明人： MACKERELL ALEXANDER D JR ,  GUVENCH OLGUN

IPC分类号： G06F19/16 ,  G01N33/15 ,  G01N33/557 ,  G06F19/00

CPC分类号： G06F19/12 ,  G06F17/18 ,  G06F19/16 ,  G06F19/706

摘要： The invention describes an explicit solvent all-atom molecular dynamics methodology (SILCS: Site Identification by Ligand Competitive Saturation) that uses small aliphatic and aromatic molecules plus water molecules to map the affinity pattern of a large molecule for hydrophobic groups, aromatic groups, hydrogen bond donors, and hydrogen bond acceptors. By simultaneously incorporating ligands representative of all these functionalities, the method is an in silico free energy-based competition assay that generates three-dimensional probability maps of fragment binding (FragMaps) indicating favorable fragment:large molecule interactions. The FragMaps may be used to qualitatively inform the design of small-molecule ligands or as scoring grids for high-throughput in silico docking that incorporates both an atomic-level description of solvation and the large molecule's flexibility.