公开(公告)号：EP1358184A1

公开(公告)日：2003-11-05

申请号：EP02717325.1

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  ADAMS, Jeffrey ,  BEMIS, Jean ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  KISELYOV, Alexander ,  OUYANG, Xiaohu ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  STEC, Markian ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1856058B1

公开(公告)日：2014-09-03

申请号：EP06736839.9

申请日：2006-03-03

申请人： Amgen Inc.

发明人： TASKER, Andrew ,  ZHANG, Dawei ,  CAO, Guo-Qiang ,  CHAKRABARTI, Partha Pratim ,  FALSEY, James Richard ,  HERBERICH, Bradley J. ,  HUNGATE, Randall W. ,  PETTUS, Liping H. ,  REED, Anthony ,  RZASA, Robert M. ,  SHAM, Kelvin K.C. ,  THAMAN, Maya C. ,  XU, Shimin

IPC分类号： C07D237/32 ,  C07D237/34 ,  C07D237/30 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04 ,  C07D487/04 ,  C07D417/04 ,  C07D491/10 ,  C07D409/04 ,  C07D401/04 ,  C07D403/04 ,  A61K31/502 ,  A61P29/00

CPC分类号： C07D409/04 ,  C07D237/30 ,  C07D237/32 ,  C07D237/34 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/10

公开(公告)号：EP2125780B1

公开(公告)日：2012-08-29

申请号：EP07863182.7

申请日：2007-12-19

申请人： Amgen Inc.

发明人： BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  GERMAIN, Julie ,  HARMANGE, Jean-Christophe ,  KIM, Tae-Seong ,  LEE, Matthew ,  LIU, Longbin ,  NORMAN, Mark H. ,  RAINBEAU, Elizabeth ,  XI, Ning ,  XU, Shimin

IPC分类号： C07D401/10

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2077998B1

公开(公告)日：2011-03-09

申请号：EP07837737.1

申请日：2007-09-04

申请人： Amgen Inc.

发明人： TASKER, Andrew ,  ZHANG, Dawei ,  PETTUS, Liping, H. ,  RZASA, Robert, M. ,  SHAM, Kelvin, K.C. ,  XU, Shimin ,  CHAKRABARTI, Partha, Pratim

IPC分类号： C07D237/30 ,  C07D237/34 ,  C07D403/12 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04 ,  A61K31/501 ,  A61P29/00

CPC分类号： C07D403/12 ,  C07D237/30 ,  C07D237/34 ,  C07D403/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

公开(公告)号：EP2125780A1

公开(公告)日：2009-12-02

申请号：EP07863182.7

申请日：2007-12-19

申请人： Amgen Inc.

发明人： BELLON, Steven ,  BOOKER, Shon ,  D'ANGELO, Noel ,  GERMAIN, Julie ,  HARMANGE, Jean-Christophe ,  KIM, Tae-Seong ,  LEE, Matthew ,  LIU, Longbin ,  NORMAN, Mark H. ,  RAINBEAU, Elizabeth ,  XI, Ning ,  XU, Shimin

IPC分类号： C07D401/10

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1358184B1

公开(公告)日：2007-05-02

申请号：EP02717325.1

申请日：2002-01-11

申请人： AMGEN INC.

发明人： CHEN, Guoqing ,  ADAMS, Jeffrey ,  BEMIS, Jean ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  KISELYOV, Alexander ,  OUYANG, Xiaohu ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  STEC, Markian ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester Chenguang

IPC分类号： C07D401/14

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1713484A2

公开(公告)日：2006-10-25

申请号：EP05722533.6

申请日：2005-01-24

申请人： AMGEN INC.

发明人： POTASHMAN, Michele ,  KIM, Tae-seong ,  BELLON, Steven ,  BOOKER, Shon ,  CHENG, Yuan ,  KIM, Joseph, L. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  HARMANGE, Jean-Christophe ,  BORG, George ,  WEISS, Matthew ,  HODOUS, Brian, L. ,  GRACEFFA, Russell ,  BUCKNER, Willianm, H. ,  MASSE, Craig, E. ,  CHOQUETTE, Deborah ,  MARTIN, Matthew, W. ,  GERMAIN, Julie ,  CHAFFEE, Stuart, C. ,  NUNES, Joseph, J. ,  PATEL, Vinod, F. ,  BUCHANAN, John L. ,  DIPIETRO, Lucian V. ,  HABGOOD; Gregory J. ,  McGOWAN; David C. ,  WHITTINGTON, Douglas A. ,  LA, Daniel

IPC分类号： A61K31/505

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutically compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1509497A1

公开(公告)日：2005-03-02

申请号：EP03729111.9

申请日：2003-05-23

申请人： Amgen Inc.

发明人： KELLY, Michael, G. ,  XU, Shimin ,  XI, Ning ,  MILLER, Philip ,  KINCAID, John, F. ,  GHIRON, Chiara ,  COULTER, Thomas

IPC分类号： C07C317/32 ,  C07C311/08 ,  C07C275/40 ,  C07C255/59 ,  C07C233/43 ,  C07C233/18 ,  C07C229/38 ,  C07C217/58 ,  C07C211/29 ,  C07C211/27 ,  C07C321/28 ,  C07D213/38 ,  C07D213/64 ,  C07D263/56 ,  C07D209/08 ,  A61P19/10 ,  C07D277/28 ,  C07D213/74 ,  C07D211/26 ,  C07D235/14 ,  C07D239/26

CPC分类号： C07C233/36 ,  C07C211/27 ,  C07C211/29 ,  C07C211/30 ,  C07C211/55 ,  C07C215/46 ,  C07C217/54 ,  C07C217/58 ,  C07C229/38 ,  C07C233/43 ,  C07C233/46 ,  C07C235/20 ,  C07C237/30 ,  C07C255/58 ,  C07C255/59 ,  C07C275/40 ,  C07C311/08 ,  C07C317/32 ,  C07C2601/02 ,  C07D207/26 ,  C07D207/27 ,  C07D207/325 ,  C07D209/08 ,  C07D209/10 ,  C07D209/44 ,  C07D211/22 ,  C07D211/70 ,  C07D213/26 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D213/73 ,  C07D213/75 ,  C07D213/82 ,  C07D215/12 ,  C07D215/14 ,  C07D231/56 ,  C07D233/22 ,  C07D235/06 ,  C07D235/10 ,  C07D235/12 ,  C07D237/08 ,  C07D237/14 ,  C07D239/26 ,  C07D239/34 ,  C07D239/42 ,  C07D241/12 ,  C07D241/42 ,  C07D249/18 ,  C07D261/08 ,  C07D263/32 ,  C07D263/56 ,  C07D271/06 ,  C07D271/08 ,  C07D271/10 ,  C07D271/12 ,  C07D277/24 ,  C07D277/28 ,  C07D277/40 ,  C07D277/42 ,  C07D277/66 ,  C07D285/01 ,  C07D295/096 ,  C07D295/135 ,  C07D295/185 ,  C07D295/26 ,  C07D307/42 ,  C07D307/52 ,  C07D307/68 ,  C07D317/46 ,  C07D317/54 ,  C07D319/18 ,  C07D321/10 ,  C07D333/16 ,  C07D333/20 ,  C07D333/56 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04

摘要： The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 本发明的化合物由以下一般结构或其药学上可接受的盐以及含有它们的组合物表示，其中变量在本文中定义，以及它们用于减少或抑制PTH分泌的用途，包括减少或抑制PTH分泌的方法，以及 用于治疗或预防与骨疾病相关的疾病如骨质疏松症或与过度分泌的PTH相关的疾病如甲状旁腺功能亢进的方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：EP1358161A2

公开(公告)日：2003-11-05

申请号：EP02717324.4

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D405/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/81 ,  C07D213/82 ,  C07D237/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Selected compounds of formula (I), wherein each of A?1 and A2¿ is independently C or N; wherein A1-A2 form part of a ring A selected from 5- or 6- membered heteroaryl; wherein X is; wherein Z is oxygen or sulfur; are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1836174B2

公开(公告)日：2019-10-02

申请号：EP05818381.5

申请日：2005-10-03

申请人： AMGEN INC.

发明人： PATEL, Vinod F. ,  KIM, Joseph L. ,  GEUNS-MEYER, Stephanie D. ,  CHAFFEE, Stuart C. ,  CEE, Victor J. ,  HODOUS, Brian L. ,  BELLON, Steven ,  HARMANGE, Jean-christophe ,  OLIVIERI, Philip R. ,  THAMAN, Maya C. ,  DIMAURO, Erin F. ,  BUCHANAN, John L. ,  MCGOWAN, David C. ,  ALBRECHT, Brian K. ,  DEAK, Holly L. ,  BEMIS, Jean E. ,  WHITE, Ryan ,  MARTIN, Matthew W. ,  HABGOOD, Gregory J. ,  MASSE, Craig E. ,  BUCKNER, William H. ,  TEMPEST, Paul A. ,  HERBERICH, Bradley J. ,  GRACEFFA, Russell ,  ZHANG, Dawei ,  XU, Shimin ,  SHAM, Kelvin ,  RZASA, Robert M. ,  FALSEY, James Richard ,  CHAKRABARTI, Partha P. ,  CAO, Guo-giang ,  TOMLINSON, Susan Ann ,  PETTUS, Liping H. ,  SMITH, Adrian Leonard ,  PARAS, Nick A. ,  LIU, Gang ,  DEMORIN, Frenel F. ,  TASKER, Andrew ,  REED, Anthony

IPC分类号： C07D239/84