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11.发明公开PEPTIDE-CONTAINING $g(a)-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS 审中-公开PEPTIDE含α-酮酰胺类ALS半胱氨酸和丝氨酸蛋白酶抑制剂
公开(公告)号：EP1021199A1
公开(公告)日：2000-07-26
申请号：EP98953275.9
申请日：1998-10-07
申请人： CEPHALON, INC.
CPC分类号： C07D207/08 , C07C311/06 , C07C311/46 , C07C311/48 , C07D207/20 , C07D207/48 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D235/06 , C07D239/42 , C07D275/06 , C07D277/40 , C07D277/54 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07K5/0202 , C07K5/06069
摘要： This invention relates to peptide-containing α-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.
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12.发明授权
公开(公告)号：EP1115390B1
公开(公告)日：2009-07-22
申请号：EP99969333.6
申请日：1999-09-20
申请人： CEPHALON, INC.
IPC分类号： A61K31/16 , A61K31/27 , A61K31/215 , C07C233/05 , C07C259/04 , C07C269/00 , A61P25/28 , A61P21/00 , A61P25/02 , A61P29/00 , A61P7/02 , A61P27/12
CPC分类号： C07C271/22 , C07C259/06 , C07C311/06 , C07C2601/14
摘要： The present invention is directed to hydroxamate-containing inhibitors of cysteine and serine proteases. Methods for the use of the protease inhibitors are also described.
摘要翻译： 本发明涉及含有异羟肟酸的半胱氨酸和丝氨酸蛋白酶抑制剂。 还描述了使用蛋白酶抑制剂的方法。
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公开(公告)号：EP1027056B1
公开(公告)日：2009-02-25
申请号：EP98953274.2
申请日：1998-10-07
申请人： CEPHALON, INC.
IPC分类号： A61K31/55 , A61K31/495 , A61K31/50 , A61K31/40 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D415/00 , C07D209/48 , C07D403/12
CPC分类号： C07D209/48 , C07D403/12
摘要： This invention relates to α-ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retard loss of muscle mass incident to various physiological states.
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14.发明授权QUINOLINE-CONTAINING ALPHA-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS 有权喹啉含α-酮酰胺抑制剂基于半胱氨酸和SERIN蛋白酶
公开(公告)号：EP1032393B1
公开(公告)日：2006-08-09
申请号：EP98952109.1
申请日：1998-10-07
发明人： CHATTERJEE, Sankar , MALLAMO, John, P. , DUNN, Derek, Douglas , JOSEF, Kurt, Allen , GU, Zi-Qiang , DAINES, Robert, A. , KINGSBURY, William, Dennis , PENDRAK, Israel , SHAM, Kelvin, C.
IPC分类号： A61K31/47 , A61K31/445 , C07D417/12 , C07D413/12 , C07D409/14 , C07D405/12 , C07D401/12 , C07D215/50 , C07D409/12 , C07D239/74
CPC分类号： C07D401/12 , C07D215/40 , C07D215/50 , C07D239/74 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to quinoline-containing α-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.
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公开(公告)号：EP1027056A1
公开(公告)日：2000-08-16
申请号：EP98953274.2
申请日：1998-10-07
申请人： CEPHALON, INC.
IPC分类号： A61K31/55 , A61K31/495 , A61K31/50 , A61K31/40 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D415/00 , C07D421/00 , C07D241/02 , C07D209/38
CPC分类号： C07D209/48 , C07D403/12
摘要： This invention relates to α-ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retard loss of muscle mass incident to various physiological states.
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16.发明公开NOVEL QUINOLINE- AND NAPHTHALENECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING CALPAIN 失效喹啉和NAPHTHALINCARBOXAMIDE，药物制剂以及抑制蛋白酶方法
公开(公告)号：EP0983243A1
公开(公告)日：2000-03-08
申请号：EP98910350.2
申请日：1998-03-13
IPC分类号： C07D215/50 , C07D215/22 , C07D215/52 , C07D409/04 , C07D405/04 , C07D401/04 , C07D221/18 , C07D417/04 , C07D401/12 , C07D405/12 , A61K31/47
CPC分类号： C07D215/50 , C07D215/22 , C07D215/52 , C07D221/18 , C07D401/06 , C07D401/10
摘要： Pharmaceutical compositions and methods of inhibiting calpain using novel quinoline- or naphthalenecarboxamides are disclosed.
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公开(公告)号：EP0871454A1
公开(公告)日：1998-10-21
申请号：EP96923756.0
申请日：1996-07-12
申请人： CEPHALON, INC.
CPC分类号： C07F9/091 , A61K38/00 , C07F9/3211 , C07F9/3252 , C07F9/3264 , C07F9/4006 , C07F9/4065 , C07F9/4075 , C07F9/5721 , C07F9/6533 , C07F9/657163 , C07F9/65742 , C07K5/06191
摘要： The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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公开(公告)号：EP1292573B1
公开(公告)日：2010-12-29
申请号：EP01937424.8
申请日：2001-05-16
申请人： CEPHALON, INC.
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , MALLAMO, John, P. , VAUGHT, Jeffry, L. , MILLER, Matthew, S.
IPC分类号： C07C323/60 , C07C317/44 , C07D333/18 , C07D277/26 , C07D417/06 , C07D231/54 , A61K31/165 , A61K31/381 , A61K31/416 , A61K31/427 , A61P1/14 , A61P9/10 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D495/04 , C07C317/44 , C07C323/60 , C07C2603/18 , C07D207/16 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06
摘要： The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredness Parkinson's disease, cerebral ischaemia, stroke, sleep apneas, eating disorders, attention deficit hyperactivity disorder, cognitive dysfunction or fatigue, for the promotion of wakefulness, stimulation of appetite or weight gain or for the treatment of disorders associated with hypofunctionality of the cerebral cortex such as depression, schizophrenia and chronic fatigue syndrome.
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公开(公告)号：EP1438288A1
公开(公告)日：2004-07-21
申请号：EP02786511.2
申请日：2002-10-25
申请人： CEPHALON, INC.
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , MALLAMO, John, P. , MILLER, Matthew, S. , TRIPATHY, Rabindranath , VAUGHT, Jeffry, L.
IPC分类号： C07C317/44 , C07C323/60 , C07D207/40 , C07D211/88 , C07D231/54 , C07D277/26 , C07D295/18 , C07D333/18 , C07D417/06 , A61K31/165 , A61P1/14 , A61P9/10 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要： The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
摘要翻译： 本发明涉及取代的硫代乙酰胺的化学组成，其制备方法和组合物在治疗疾病中的用途。
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公开(公告)号：EP0827505B1
公开(公告)日：2002-10-09
申请号：EP96911556.7
申请日：1996-04-03
IPC分类号： C07D498/22 , A61K31/55
CPC分类号： C07D498/22 , C07H9/06 , C07H19/044
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