-
1.发明授权QUINOLINE-CONTAINING ALPHA-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS 有权喹啉含α-酮酰胺抑制剂基于半胱氨酸和SERIN蛋白酶
公开(公告)号：EP1032393B1
公开(公告)日：2006-08-09
申请号：EP98952109.1
申请日：1998-10-07
发明人： CHATTERJEE, Sankar , MALLAMO, John, P. , DUNN, Derek, Douglas , JOSEF, Kurt, Allen , GU, Zi-Qiang , DAINES, Robert, A. , KINGSBURY, William, Dennis , PENDRAK, Israel , SHAM, Kelvin, C.
IPC分类号： A61K31/47 , A61K31/445 , C07D417/12 , C07D413/12 , C07D409/14 , C07D405/12 , C07D401/12 , C07D215/50 , C07D409/12 , C07D239/74
CPC分类号： C07D401/12 , C07D215/40 , C07D215/50 , C07D239/74 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to quinoline-containing α-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.
-
2.发明公开QUINOLINE-CONTAINING $g(a)-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS 有权喹啉酮酰胺含基于抑制剂和半胱氨酸蛋白酶SERIN
公开(公告)号：EP1032393A1
公开(公告)日：2000-09-06
申请号：EP98952109.1
申请日：1998-10-07
发明人： CHATTERJEE, Sankar , MALLAMO, John, P. , DUNN, Derek, Douglas , JOSEF, Kurt, Allen , GU, Zi-Qiang , DAINES, Robert, A. , KINGSBURY, William, Dennis , PENDRAK, Israel , SHAM, Kelvin, C.
IPC分类号： A61K31/47 , A61K31/445 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/26
CPC分类号： C07D401/12 , C07D215/40 , C07D215/50 , C07D239/74 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to quinoline-containing α-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.
-
3.发明授权
公开(公告)号：EP1660507B1
公开(公告)日：2009-08-05
申请号：EP04786507.6
申请日：2004-08-13
申请人： CEPHALON, INC.
发明人： BERNAREGGI, ALberto , CASSARA, Paolo, G. , CHATTERJEE, Sankar , FERRETTI, Edmondo , IQBAL, Mohamed , MENTA, Ernesto , MESSINA MCLAUGHLIN, Patricia, A. , OLIVA, Ambrogio , BERNARDINI, Rafaella , DE NUNARI, Sergio , D'ARASMO, Germano
摘要： The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
摘要翻译： 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它病症的方法中。
-
4.发明公开CYCLOALKANOPYROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS 有权CYCLOALKANOPYROLOCARBAZOLE衍生物及其作为PARP，VEGFR2和MLK3抑制剂的用途
公开(公告)号：EP2066324A2
公开(公告)日：2009-06-10
申请号：EP07809679.9
申请日：2007-06-19
申请人： CEPHALON, INC.
发明人： CHATTERJEE, Sankar , DIEBOLD, James, L. , DUNN, Derek , HUDKINS, Robert, L. , DANDU, Reddeppareddy , WELLS, Gregory, J. , ZULLI, Allison, L.
IPC分类号： A61K31/437 , A61P43/00
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要： The present invention is directed to novel multicyclic molecules of Formula (IIIIa)* that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP3 VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译： 本发明涉及介导酶活性的式（IIIaa）*的新型多环分子。 具体而言，所述化合物可有效治疗与PARP3VEGFR2和MLK3酶（包括例如神经变性疾病，炎症，局部缺血和癌症）的活性有关的疾病或疾病状态。
-
公开(公告)号：EP1292573A2
公开(公告)日：2003-03-19
申请号：EP01937424.8
申请日：2001-05-16
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , MALLAMO, John, P. , VAUGHT, Jeffry, L. , MILLER, Matthew, S.
IPC分类号： C07C323/60 , C07C317/44 , C07D333/18 , C07D277/26 , C07D417/06 , C07D231/54 , A61K31/165 , A61K31/381 , A61K31/416 , A61K31/427 , A61P1/14 , A61P9/10 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D495/04 , C07C317/44 , C07C323/60 , C07C2603/18 , C07D207/16 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06
摘要： The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredness Parkinson's disease, cerebral ischaemia, stroke, sleep apneas, eating disorders, attention deficit hyperactivity disorder, cognitive dysfunction or fatigue, for the promotion of wakefulness, stimulation of appetite or weight gain or for the treatment of disorders associated with hypofunctionality of the cerebral cortex such as depression, schizophrenia and chronic fatigue syndrome.
摘要翻译： 本发明涉及式（I）的取代的硫代乙酰胺：其中Ar 1，Ar 2，R 1 -R 4和n如权利要求中所定义，其制备方法和硫代乙酰胺用于治疗嗜睡，疲劳，帕金森氏症 疾病，脑缺血，中风，睡眠呼吸暂停，进食障碍，注意缺陷多动障碍，认知功能障碍或疲劳; 用于促进觉醒，刺激食欲或体重增加或用于治疗与大脑皮质功能低下相关的疾病，例如抑郁症，精神分裂症和慢性疲劳综合征。 。
-
公开(公告)号：EP0786996A1
公开(公告)日：1997-08-06
申请号：EP95940706.0
申请日：1995-11-03
申请人： CEPHALON, INC.
IPC分类号： C12N9 , A61K31 , A61P43 , C07C59 , C07D235 , C07D249 , C07D311 , C07D405 , C07D471 , C07D521
CPC分类号： C07D405/12 , C07C59/84 , C07D235/22 , C07D249/18 , C07D311/82 , C07D471/04
摘要： The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of the protease inhibitors are also described.
-
7.发明公开SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 审中-公开取代PHENOXYPROPYLCYCLOAMINDERIVATE比组胺-3（H 3）受体的配体
公开(公告)号：EP2459529A1
公开(公告)日：2012-06-06
申请号：EP10730019.6
申请日：2010-07-01
申请人： Cephalon, Inc. , Cephalon France
发明人： BACON, Edward R. , BAILEY, Thomas , CHATTERJEE, Sankar , DUNN, Derek , HOSTETLER, Greg A. , HUDKINS, Robert L. , LESUR, Brigitte , SUNDAR, Babu G. , YUE, Christophe , ZULLI, Allison L.
IPC分类号： C07D207/06 , C07D207/10 , C07D209/44 , C07D211/14 , C07D211/38 , C07D211/46 , A61K31/496 , A61K31/5377 , A61P25/00 , C07D215/06 , C07D217/04 , C07D241/08 , C07D401/12 , C07D403/12 , C07D407/12
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H
3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.-
公开(公告)号：EP1438288B1
公开(公告)日：2009-04-29
申请号：EP02786511.2
申请日：2002-10-25
申请人： CEPHALON, INC.
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , MALLAMO, John, P. , MILLER, Matthew, S. , TRIPATHY, Rabindranath , VAUGHT, Jeffry, L.
IPC分类号： C07C317/44 , C07C323/60 , C07D207/40 , C07D211/88 , C07D231/54 , C07D277/26 , C07D295/18 , C07D333/18 , C07D417/06 , A61K31/165 , A61P1/14 , A61P9/10 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要： The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
-
公开(公告)号：EP1748979A1
公开(公告)日：2007-02-07
申请号：EP05735495.3
申请日：2005-04-13
申请人： CEPHALON, INC.
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , GRUNER, John, A. , TRIPATHY, Rabindranath
IPC分类号： C07C317/44 , C07C323/60 , C07D333/22 , C07D333/18 , C07D307/38 , C07D249/12
CPC分类号： C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要： The present invention provides compounds of the structure (I) wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases such as for example excessive sleepiness, promotion and/or improvement of wakefulness.
摘要翻译： 本发明提供了结构（I）的化合物，其中构成成员在本文中定义，包括其药物组合物以及治疗疾病例如过度嗜睡，促进和/或改善觉醒的方法。
-
公开(公告)号：EP0789578B1
公开(公告)日：2003-06-04
申请号：EP95939165.7
申请日：1995-11-14
申请人： CEPHALON, INC.
IPC分类号： A61K38/05 , C07K5/04 , C07C229/00
CPC分类号： C07D209/48 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/277 , A61K31/353 , A61K31/4035 , A61K38/00 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07C2601/08 , C07D311/70 , C07F5/025 , C07K5/0207 , C07K5/06095
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.026 秒)
