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11.发明授权N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS 有权N-（咪唑并嘧啶-7-基）-HETEROARYLAMID-衍生物及其作为抑制剂PDE10A
公开(公告)号：EP2552918B1
公开(公告)日：2014-06-11
申请号：EP11711068.4
申请日：2011-03-23
发明人： ALVAREZ SÁNCHEZ, Rubén , BLEICHER, Konrad , FLOHR, Alexander , GOBBI, Luca , GROEBKE ZBINDEN, Katrin , KOERNER, Matthias , KUHN, Bernd , PETERS, Jens-Uwe , RUDOLPH, Markus
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P25/00 , A61P25/18
CPC分类号： C07D487/04 , C07D519/00
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公开(公告)号：EP2526098A1
公开(公告)日：2012-11-28
申请号：EP11701639.4
申请日：2011-01-19
发明人： BLEICHER, Konrad , FLOHR, Alexander , GROEBKE ZBINDEN, Katrin , KOERNER, Matthias , KUHN, Bernd , PETERS, Jens-Uwe , RODRIGUEZ SARMIENTO, Rosa Maria , VIEIRA, Eric
IPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/506 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型含氮杂芳基衍生物，其中R1，R2，R3，R4，R5，A1，A2和Y如说明书和权利要求书中所定义，以及生理上可接受的盐 及其酯。 这些化合物抑制PDE10A，可用作药物。
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公开(公告)号：EP1532132B1
公开(公告)日：2008-03-19
申请号：EP03766236.8
申请日：2003-07-18
发明人： ALANINE, Alexander , BLEICHER, Konrad , GUBA, Wolfgang , HAAP, Wolfgang , KUBER, Dagmar , LUEBBERS, Thomas , PLANCHER, Jean-Marc , ROGERS-EVANS, Mark , SCHNEIDER, Gisbert , ZUEGGE, Jochen , ROCHE, Olivier
IPC分类号： C07D317/62 , C07D405/12 , C07D317/54 , C07D451/06 , A61K31/36
CPC分类号： C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要： The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
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公开(公告)号：EP1532132A1
公开(公告)日：2005-05-25
申请号：EP03766236.8
申请日：2003-07-18
发明人： ALANINE, Alexander , BLEICHER, Konrad , GUBA, Wolfgang , HAAP, Wolfgang , KUBE, Dagmar , LUEBBERS, Thomas , PLANCHER, Jean-Marc , ROGERS-EVANS, Mark , SCHNEIDER, Gisbert , ZUEGGE, Jochen , ROCHE, Olivier
IPC分类号： C07D317/62 , C07D405/12 , C07D317/54 , C07D451/06 , A61K31/36
CPC分类号： C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要： The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和X如说明书和权利要求书中所定义。 这些化合物可用于治疗和/或预防与CB1受体调节有关的疾病。
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15.发明公开LIPIDATED INCRETIN RECEPTOR LIGAND HUMAN IMMUNOGLOBULIN FC-REGION FUSION POLYPEPTIDES 审中-公开融合OFF脂化肠降血糖素受体配体和人免疫球蛋白Fc区
公开(公告)号：EP3082847A1
公开(公告)日：2016-10-26
申请号：EP14830920.6
申请日：2014-12-19
发明人： BELLI, Sara , BLEICHER, Konrad , DIMARCHI, Richard D. , HOFFMANN, Eike , KITAS, Eric A. , KONKAR, Anish A.
IPC分类号： A61K38/26 , C07K14/605 , A61K47/48
CPC分类号： A61K38/26 , A61K38/00 , A61K45/06 , A61K47/543 , C07K14/605 , C07K2319/30
摘要： Herein is reported a fusion polypeptide comprising i) one, two, three or four incretin receptor ligand polypeptides, and ii) one human immunoglobulin Fc-region, wherein at least one of the incretin receptor ligand polypeptides comprises an amino acid that is covalently conjugated to a lipid, and wherein each of the one, two, three or four incretin receptor ligand polypeptides is covalently conjugated by a peptide bond to a terminus of the human immunoglobulin Fc-region, whereby to each terminus of the human immunoglobulin Fc-region only a single incretin receptor ligand polypeptide is conjugated.
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16.发明授权NOVEL HETEROBICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF LIVER CARNITINE PALMITOYL TRANSFERASE 有权新杂衍生物肝脏肉碱棕榈酰TRANSFERASEHEMMER
公开(公告)号：EP1926711B1
公开(公告)日：2012-11-07
申请号：EP06793207.9
申请日：2006-09-05
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona Maria , CHOMIENNE, Odile , MATTEI, Patrizio , SCHULZ-GASCH, Tanja
IPC分类号： C07D209/10 , C07D403/12 , C07D413/12 , C07D215/58 , C07D223/16
CPC分类号： C07D223/16 , C07D209/10 , C07D215/58 , C07D403/12 , C07D413/12
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公开(公告)号：EP1996563A1
公开(公告)日：2008-12-03
申请号：EP07726290.5
申请日：2007-02-02
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona, M. , CHOMIENNE, Odile , MATTEI, Patrizio , OBST SANDER, Ulrike
IPC分类号： C07D241/42 , C07D263/56 , C07D265/14 , C07D265/36 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04 , C07D498/04 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61P3/00
CPC分类号： C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要： The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPTl and can be used as medicaments.
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