-
11.发明公开
公开(公告)号：EP2288727A1
公开(公告)日：2011-03-02
申请号：EP09747492.8
申请日：2009-05-13
发明人： BAKER, Joffre, B. , WATSON, Drew , MADDALA, Tara , SHAK, Steven , MAURO, David, J. , FORD, Shirin, K.
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention provides methods and compositions to facilitate determining whether an EGFR-expressing cancer in an individual is an EGFR inhibitor-responsive cancer, as well as methods for determining the likelihood that a patient having an EGFR-expressing cancer will exhibit a beneficial response to an EGFR inhibitor therapy. The methods generally involve determining a normalized expression level of a gene product that correlates with EGFR inhibitor responsiveness.
摘要翻译： 本发明提供了有助于确定个体中的表达EGFR的癌症是否是EGFR抑制剂响应性癌症的方法和组合物，以及用于确定具有表达EGFR的癌症的患者将显示对 一种EGFR抑制剂疗法。 该方法通常涉及确定与EGFR抑制剂响应性相关的基因产物的标准化表达水平。
-
12.发明公开MOLECULAR INDICATORS OF BREAST CANCER PROGNOSIS AND PREDICTION OF TREATMENT RESPONSE 有权分子指标用于乳腺癌预后和治疗反应预测到治疗
公开(公告)号：EP1815014A2
公开(公告)日：2007-08-08
申请号：EP05821698.7
申请日：2005-11-04
IPC分类号： C12Q1/68 , G01N33/574 , C12N15/10
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G06F19/18 , G06F19/20
摘要： The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer. In particular, the invention concerns certain genes, the varied expression of which indicates the likelihood of recurrence of surgically resected breast cancer in patients who are not treated with a therapeutic agent in the adjuvant setting. In addition, the invention concerns the use of quantitative measurement of the expression of certain genes, including the ESR1 gene, that measures as a continuous variable, to determine (a) the likelihood of a beneficial response to the anti-estrogen therapeutic agent, such as tamoxifen; and (b) the potential magnitude of beneficial response to chemotheraphy.
-
13.发明公开
公开(公告)号：EP1636380A2
公开(公告)日：2006-03-22
申请号：EP04753936.6
申请日：2004-05-28
申请人： Genomic Health, Inc.
发明人： AGUS, David , BAKER, Joffre, B. , NATALE, Ronald , SHAK, Steven
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
-
公开(公告)号：EP1590487A2
公开(公告)日：2005-11-02
申请号：EP04708653.3
申请日：2004-02-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular charaterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
-
公开(公告)号：EP1587957A2
公开(公告)日：2005-10-26
申请号：EP04702177.9
申请日：2004-01-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
-
公开(公告)号：EP1836629B1
公开(公告)日：2020-03-04
申请号：EP05817266.9
申请日：2005-11-04
IPC分类号： G16B20/00 , C12Q1/6886 , G16B25/00
-
17.发明授权
公开(公告)号：EP2288727B1
公开(公告)日：2013-07-10
申请号：EP09747492.8
申请日：2009-05-13
发明人： BAKER, Joffre, B. , WATSON, Drew , MADDALA, Tara , SHAK, Steven , MAURO, David, J. , FORD, Shirin, K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
-
18.发明公开TESTS TO PREDICT RESPONSIVENESS OF CANCER PATIENTS TO CHEMOTHERAPY TREATMENT OPTIONS 有权测试为癌症患者的治疗方案化疗的预测应答率
公开(公告)号：EP2294215A1
公开(公告)日：2011-03-16
申请号：EP09747388.8
申请日：2009-05-12
申请人： Genomic Health, Inc. , Aventis Inc.
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.
-
公开(公告)号：EP1587957B1
公开(公告)日：2010-06-09
申请号：EP04702177.9
申请日：2004-01-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
-
公开(公告)号：EP1597391B1
公开(公告)日：2008-10-29
申请号：EP04712947.3
申请日：2004-02-19
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q1/6886 , C12Q2600/118 , C12Q2525/161 , C12Q2525/149 , C12Q2539/105 , C12Q2531/113 , C12Q2565/101 , C12Q2565/501
摘要： The invention is based on the use of intronic RNA in monitoring gene expression. Accordingly, the present invention concerns methods of gene expression profiling using intronic RNA, the expression of which correlates with the expression of corresponding exonic RNA, and diagnostic and prognostic methods based on the results of such gene expression studies.
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.023 秒)
