公开(公告)号：EP1851251A2

公开(公告)日：2007-11-07

申请号：EP06735490.2

申请日：2006-02-17

申请人： MEDAREX, INC.

发明人： CARDARELLI, Josephine, M. ,  PASSMORE, David, B. ,  ALBANESE, Jenny ,  ZHU, Lei

IPC分类号： C07K16/30 ,  A61P35/00

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/23 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77

摘要： The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.

公开(公告)号：EP1848745A2

公开(公告)日：2007-10-31

申请号：EP06720888.4

申请日：2006-02-17

申请人： MEDAREX, INC.

发明人： CARDARELLI, Josephine, M. ,  BLACK, Amelia, Nancy

IPC分类号： C07K16/30

CPC分类号： C07K16/2878 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/732

摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.

公开(公告)号：EP1740210A2

公开(公告)日：2007-01-10

申请号：EP05744084.4

申请日：2005-03-29

申请人： MEDAREX, INC.

发明人： GRAZIANO, Robert ,  CARDARELLI, Josephine, M. ,  KEMPE, Thomas D. ,  CUTTER, Beth ,  SRINIVASAN, Mohan

IPC分类号： A61K39/395 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K16/3061 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.

公开(公告)号：EP2046834B9

公开(公告)日：2013-04-10

申请号：EP07792618.6

申请日：2007-08-10

申请人： ONO PHARMACEUTICAL CO., LTD. ,  Medarex, Inc.

发明人： POGUE, Sarah, L. ,  KORMAN, Alan J. ,  CARDARELLI, Josephine, M. ,  SRINIVASAN, Mohan ,  CHEN, Bingliang ,  BELL, Alasdair, F.

IPC分类号： C07K16/24 ,  A61K39/395 ,  A61P3/10 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C12P21/08 ,  C12N5/22 ,  C12N15/13

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP1960434B1

公开(公告)日：2012-07-11

申请号：EP06840172.8

申请日：2006-12-08

申请人： Medarex, Inc.

发明人： VISTICA, Cynthia, A. ,  HOLMES, Eric, H. ,  BRAMS, Peter ,  WITTE, Alison ,  CARDARELLI, Josephine, M.

IPC分类号： C07K16/30 ,  A61P35/00 ,  A61K39/395

CPC分类号： C07K16/3084 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.

公开(公告)号：EP1691837B1

公开(公告)日：2012-06-20

申请号：EP04813771.5

申请日：2004-12-10

申请人： Medarex, Inc.

发明人： DESHPANDE, Shrikant ,  HUANG, Haichun ,  SRINIVASAN, Mohan ,  CARDARELLI, Josephine, M. ,  WANG, Changyu ,  PASSMORE, David ,  RANGAN, Vangipuram, S. ,  LANE, Thomas, E. ,  KEIRSTEAD, Hans, S. ,  LIU, Michael, T.

IPC分类号： C07K16/24 ,  A61K39/395 ,  C12N5/18 ,  C07K14/52 ,  A61P37/06 ,  A61P31/04 ,  A61P31/12

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

公开(公告)号：EP1631590B1

公开(公告)日：2011-07-27

申请号：EP04750579.7

申请日：2004-04-23

申请人： Medarex, Inc.

发明人： CARDARELLI, Josephine, M. ,  CHEN, Tseng-hui, Timothy ,  KING, David ,  BEBBINGTON, Christopher, R. ,  POGUE, Sarah, Lee ,  CARR, Francis J. ,  WILLIAMS, Stephen

IPC分类号： C07K16/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.

摘要翻译： 公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。

公开(公告)号：EP1940470A2

公开(公告)日：2008-07-09

申请号：EP06825196.6

申请日：2006-09-26

申请人： Medarex, Inc.

发明人： BOYD, Sharon, Elaine ,  CHEN, Liang ,  GANWAR, Sanjeev ,  GUERLAVAIS, Vincent ,  HORGAN, Kilian ,  SUFI, Bilal ,  CARDARELLI, Josephine, M. ,  PAN, Chin ,  HUANG, Haichun ,  KING, David, John

IPC分类号： A61K47/48 ,  C07K16/28 ,  C07K5/06 ,  A61P13/08

CPC分类号： C07K5/06052 ,  A61K38/00 ,  A61K47/6803 ,  A61K47/6805 ,  A61K47/6809 ,  A61K47/6869 ,  A61K47/6889 ,  B82Y30/00

摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.

公开(公告)号：EP1934261A2

公开(公告)日：2008-06-25

申请号：EP06815627.2

申请日：2006-09-26

申请人： MEDAREX, INC.

发明人： TERRETT, Jonathan, Alexander ,  LU, Li-sheng ,  KING, David, John ,  CARDARELLI, Josephine, M. ,  PAN, Chin ,  HUANG, Haichun ,  COCCIA, Marco, A.

IPC分类号： C07K16/28

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/466

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

公开(公告)号：EP1851250A2

公开(公告)日：2007-11-07

申请号：EP06735489.4

申请日：2006-02-17

申请人： MEDAREX, INC.

发明人： HUANG, Haichun ,  KING, David, John ,  PAN, Chin ,  CARDARELLI, Josephine, M.

IPC分类号： C07K16/28 ,  A61P13/08

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/21

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.