公开(公告)号：EP3130021B1

公开(公告)日：2018-12-26

申请号：EP15769204.7

申请日：2015-03-20

申请人： Temple University Of The Commonwealth System Of Higher Education

发明人： ZDILLA, Michael J. ,  WUNDER, Stephanie L. ,  CHINNAM, Parameswara Rao

IPC分类号： H01M10/056 ,  H01M10/052

CPC分类号： H01M10/0565 ,  H01M4/02 ,  H01M6/14 ,  H01M6/16 ,  H01M6/36 ,  H01M10/052 ,  H01M10/056 ,  H01M2300/0017 ,  H01M2300/0085

摘要： The present invention relates to compositions comprising ionic compounds surrounded by organic matrices, and methods for producing such compositions. In various embodiments, the compositions of the present invention are co-crystals of an organic compound and a salt. The organic compound forms matrices with channel structures, wherein the organic matrices interact relatively poorly with the salt, thus allowing for excellent ion mobility through the channel structures. In one embodiment, the compositions are soft-solid electrolytes, comprising ions such as lithium or sodium, which can be used in batteries or other electrochemical devices. The electrolyte compositions of the present invention exhibit relatively high ionic conductivities with a negligible activation barrier for ion migration, i.e., the compositions exhibit barrierless ion conduction. In addition, the compositions exhibit good conductivities at very low temperatures, making them useful in a variety of low temperature applications. In one embodiment, the present invention further relates to free-standing films comprising the co-crystals of the present invention, and methods for preparing such films.

公开(公告)号：EP3407918A1

公开(公告)日：2018-12-05

申请号：EP17744745.5

申请日：2017-01-24

申请人： Excision Biotherapeutics ,  Temple University Of The Commonwealth System Of Higher Education

发明人： KHALILI, Kamel ,  MALCOLM, Thomas

IPC分类号： A61K48/00 ,  A61P31/12 ,  A61P31/18 ,  C12N15/63

CPC分类号： C07K14/00 ,  C12N15/102 ,  C12N2740/16021

摘要： A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) in the proviral DNA, and inactivating the proviral DNA. A composition for use in inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus including isolated nucleic acid sequences comprising a CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a human immunodeficiency virus..

公开(公告)号：EP3368692A1

公开(公告)日：2018-09-05

申请号：EP16860925.3

申请日：2016-10-28

申请人： Temple University Of The Commonwealth System Of Higher Education

发明人： POMERANTZ, Richard, T. ,  KENT, Tatiana

IPC分类号： C12Q1/68 ,  C12N9/12

CPC分类号： C12N9/1252 ,  C07H21/04 ,  C12N2310/344 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6844 ,  C12Q2521/101 ,  C12Q2525/101 ,  C12Q2563/137 ,  C12Y207/07007

摘要： The invention provides compositions and methods for modifying the 3′-terminal ends of nucleic acids using DNA polymerase θ terminal transferase activity.

公开(公告)号：EP3356521A2

公开(公告)日：2018-08-08

申请号：EP16852345.4

申请日：2016-09-23

申请人： Temple University - Of The Commonwealth System of Higher Education

发明人： KHALILI, Kamel ,  HU, Wenhui

IPC分类号： C12N9/22 ,  C12N15/113 ,  C12Q1/68 ,  C07K14/16

CPC分类号： C12N9/22 ,  A61K31/7105 ,  A61K38/43 ,  C12N15/102 ,  C12N15/1132 ,  C12N2310/20 ,  C12N2740/15043

摘要： see item 8 RO/106

公开(公告)号：EP3325029A1

公开(公告)日：2018-05-30

申请号：EP16828556.7

申请日：2016-07-21

申请人： Temple University Of The Commonwealth System Of Higher Education

发明人： LELKES, Peter, I. ,  HAR-EL, Yah-el, H. ,  MARCINKIEWICZ, Cezary ,  LAZAROVICI, Philip ,  BAHARLOU, Sogol, Moaiyed ,  GERSTENHABER, Jonathon, A.

IPC分类号： A61L27/38 ,  A61L27/18 ,  A61F2/02 ,  A61K9/70 ,  A61K47/42

CPC分类号： A61K38/168 ,  A61L15/26 ,  A61L15/32 ,  A61L15/44 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/008 ,  A61L27/18 ,  A61L27/222 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/412 ,  A61P17/02 ,  C08L67/04

摘要： Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.

公开(公告)号：EP3302709A2

公开(公告)日：2018-04-11

申请号：EP16804274.5

申请日：2016-06-01

申请人： Temple University - Of The Commonwealth System of Higher Education

发明人： KHALILI, Kamel ,  HU, Wenhui ,  ZHANG, Yonggang

IPC分类号： A61P31/18 ,  A61K48/00 ,  C12N5/10 ,  C12N15/63 ,  C12N9/22

CPC分类号： A61K38/465 ,  A61K48/00 ,  A61P31/18 ,  C12N9/22 ,  C12N15/11 ,  C12N15/1132 ,  C12N15/907 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2320/11

摘要： Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.

公开(公告)号：EP3271021A2

公开(公告)日：2018-01-24

申请号：EP16769422.3

申请日：2016-03-18

申请人： Temple University Of The Commonwealth System Of Higher Education

发明人： KHALILI, Kamel

IPC分类号： A61P31/12 ,  A61P31/18 ,  C12N9/22 ,  C12N15/63 ,  C12N15/49

CPC分类号： C12N15/111 ,  A61K45/06 ,  A61K48/005 ,  A61K48/0075 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/1132 ,  C12N15/86 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/30 ,  C12N2740/16062 ,  C12N2800/107 ,  C12N2800/22 ,  C12N2830/00 ,  C12N2830/30 ,  C12N2830/60

摘要： Compositions and methods are provided for Tat-inducible expression of a CRISPR-associated endonuclease by a truncated HIV LTR promoter containing at least a core region and a TAR region of a HIV LTR promoter. The compositions may be used as a therapeutic treatment for the treatment and/or prevention of HIV.

公开(公告)号：EP3243513A1

公开(公告)日：2017-11-15

申请号：EP17171427.2

申请日：2012-01-26

申请人： University of Rochester ,  Board of Regents of the University of Nebraska ,  Temple University - Of The Commonwealth System of Higher Education

发明人： DUNMAN, Paul M. ,  OLSON, Patrick D. ,  CHILDERS, Wayne

IPC分类号： A61K31/427 ,  A61K45/06

CPC分类号： A61K31/427 ,  A61K31/341 ,  A61K31/402 ,  A61K45/06 ,  C07D207/337 ,  C07D307/56 ,  C07D307/68 ,  C07D405/06 ,  C07D417/06 ,  C12Q1/44 ,  G01N2333/922 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

摘要： Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.

摘要翻译： 本文描述了细菌核糖核酸酶（例如RnpA）的小分子抑制剂及其合成和使用方法。 使用这些化合物的方法包括治疗和预防微生物感染和抑制细菌核糖核酸酶。

公开(公告)号：EP3212183A1

公开(公告)日：2017-09-06

申请号：EP15854238.1

申请日：2015-10-30

申请人： University of Rochester ,  Temple University Of The Commonwealth System Of Higher Education

发明人： DUNMAN, Paul M. ,  CHILDERS, Wayne

IPC分类号： A61K31/341 ,  A61K45/06 ,  C07D417/06

CPC分类号： A61K31/341 ,  A61K9/0043 ,  A61K9/06 ,  A61K31/17 ,  A61K31/343 ,  A61K31/351 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/47 ,  A61K31/497 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00

摘要： Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.

摘要翻译： 提供了包括RNA酶P抑制剂和tRNA合成酶抑制剂的协同药物组合物，以及它们用于治疗感染的方法。 本文还提供了使用组合物抑制细胞中的细菌tRNA合成酶并使表面上的细菌去乳化的方法。

公开(公告)号：EP1689706B1

公开(公告)日：2017-01-11

申请号：EP04816944.5

申请日：2004-11-08

申请人： Temple University - Of The Commonwealth System of Higher Education ,  Onconova Therapeutics, Inc.

发明人： REDDY, Premkumar, E. ,  REDDY, Ramana, M., V. ,  BELL, Stanley, C.

IPC分类号： C07C317/10 ,  A61K31/10 ,  C07D333/18 ,  C07C317/18 ,  C07C317/28 ,  C07C317/44 ,  C07D207/333 ,  C07D277/26 ,  C07D213/34 ,  C07D307/38

CPC分类号： C07C317/44 ,  C07C317/10 ,  C07C317/18 ,  C07C317/28 ,  C07D207/333 ,  C07D213/34 ,  C07D277/26 ,  C07D307/38 ,  C07D333/18