公开(公告)号：EP2969202A1

公开(公告)日：2016-01-20

申请号：EP14779902.7

申请日：2014-03-11

Applicant: Rutgers, the State University of New Jersey

Inventor： ZHANG, Xumu

IPC: B01J31/00

CPC classification number: B01J31/2409 ,  B01J31/2414 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0263 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/26 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/84 ,  B01J2531/842 ,  B01J2540/22 ,  B01J2540/225 ,  B01J2540/66 ,  B01J2540/68 ,  C07B53/00 ,  C07C201/12 ,  C07C209/52 ,  C07C213/02 ,  C07D307/38 ,  C07F17/00 ,  C07F17/02 ,  C07C205/04 ,  C07C205/09 ,  C07C205/32 ,  C07C211/30 ,  C07C211/29 ,  C07C211/27 ,  C07C217/58

Abstract: A ligand having the structure or its enantiomer; (I) wherein: each one of R
a , R
b , R
c and R
d is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH
2 NH; *CH(CH
3 )NH (C*,
R ); and the organocatalyst is an organic molecule catalyst covalently bound to the bridge group. Also, a catalyst having the structure or its enantiomer: (II) wherein: each one of R
a , R
b , R
c and R
d is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH
2 NH; *CH(CH
3 )NH (C*,
R ); and *CH(CH
3 )NH (C*,
S ); the organocatalyst is an organic molecule catalyst covalently bound to the bridge group; and M is selected from the group consisting of Rh, Pd, Cu, Ru, Ir, Ag, Au, Zn, Ni, Co, and Fe.

Abstract translation: 具有该结构或其对映体的配体; （I）其中：R a，R b，R c和R d中的每一个选自烷基，环烷基和芳基; 桥基选自CH 2 NH; * CH（CH 3）NH（C *，R）; 有机催化剂是与桥基共价结合的有机分子催化剂。 此外，具有以下结构或其对映异构体的催化剂：（II）其中：R a，R b，R c和R d中的每一个选自烷基，环烷基和芳基; 桥组选自CH 2 NH; * CH（CH 3）NH（C *，R）; 和* CH（CH 3）NH（C *，S）; 有机催化剂是与桥基共价结合的有机分子催化剂; M选自Rh，Pd，Cu，Ru，Ir，Ag，Au，Zn，Ni，Co和Fe。

公开(公告)号：EP2950927A1

公开(公告)日：2015-12-09

申请号：EP13814239.3

申请日：2013-10-31

Applicant: Council of Scientific & Industrial Research

Inventor： KURESHY, Rukhsana, Ilyas ,  KHAN, Noor-Ul-Hasan ,  ABDI, Sayed, Hasan, Razi ,  BAJAJ, Hari, Chand ,  ROY, Tamal ,  DAS, Anjan

IPC: B01J31/18 ,  B01J31/22

CPC classification number: C07C201/12 ,  B01J31/1805 ,  B01J31/2217 ,  B01J2231/342 ,  B01J2531/0252 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/62 ,  B01J2531/842 ,  B01J2531/845 ,  C07F1/08 ,  C07F3/06 ,  C07F11/00 ,  C07F15/02 ,  C07F15/06

Abstract: The present invention relates to preparation of highly efficient chiral recyclable homogeneous catalysts generated in situ by the reaction of chiral oligomeric [H
4 ] ligands and a metal salt taken in 1:1 molar ratio for asymmetric nitroaldol reaction,wherein nitroaldol reactions of various aldehydes such as aromatic, aliphatic α, β-unsaturated aldehydes, alicyclic aldehydes and nitroalkenes were carried out to produce optically active β-nitroalcohols in high yield and with moderate to excellent enantioselectivity (ee up to >95 %) in presence of a base and an optically active chiral recyclable homogeneous catalyst represented by the following formula (I).

公开(公告)号：EP1301458B1

公开(公告)日：2015-09-09

申请号：EP01950437.2

申请日：2001-06-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： GRUBBS, Robert, H. ,  CHATTERJEE, Arnab, K. ,  MORGAN, John, P. ,  SCHOLL, Matthias ,  CHOI, Tae-Lim

IPC: C07C317/14 ,  C07C233/09 ,  C07C205/06 ,  C07C61/35 ,  C07D323/02 ,  C07D263/04 ,  C07D303/04 ,  C07D309/18 ,  C07F7/04 ,  C07B37/00 ,  C07C45/67 ,  C07C45/69 ,  C07C45/72 ,  C07C67/293 ,  C07C67/343 ,  C07C231/12 ,  C07C259/06 ,  C07C315/04 ,  C07D303/22 ,  C07C309/12 ,  C07D315/00 ,  C07D317/12 ,  C07D319/12 ,  C07D321/08 ,  C07D263/22 ,  C07D309/30 ,  C07D319/14

CPC classification number: C07D303/22 ,  C07B37/00 ,  C07C45/673 ,  C07C45/69 ,  C07C45/72 ,  C07C67/293 ,  C07C67/343 ,  C07C201/12 ,  C07C231/12 ,  C07C259/06 ,  C07C315/04 ,  C07D263/22 ,  C07D263/24 ,  C07D309/12 ,  C07D309/30 ,  C07D315/00 ,  C07D317/12 ,  C07D319/12 ,  C07D319/14 ,  C07D321/08 ,  C07D413/12 ,  C07C49/597 ,  C07C317/14 ,  C07C233/09 ,  C07C233/11 ,  C07C205/06 ,  C07C205/56

公开(公告)号：EP2716630A4

公开(公告)日：2015-06-03

申请号：EP12792034

申请日：2012-05-17

Applicant: SUMITOMO CHEMICAL CO

Inventor： IKEMOTO TETSUYA ,  LUTETE LEOPOLD MPAKA ,  AIKAWA TOSHIAKI

IPC: C07D209/52 ,  C07C205/29 ,  C07C217/44 ,  C07C271/16 ,  C07C271/18 ,  C07D317/16 ,  C07D317/28

CPC classification number: C07C223/02 ,  C07C201/12 ,  C07C205/29 ,  C07C213/02 ,  C07C213/08 ,  C07C217/44 ,  C07C269/04 ,  C07C271/16 ,  C07C271/18 ,  C07C2601/08 ,  C07D209/52 ,  C07D317/16 ,  C07D317/28 ,  C07C205/44

公开(公告)号：EP2632889A4

公开(公告)日：2015-01-07

申请号：EP11835740

申请日：2011-10-27

Applicant: MAPI PHARMA LTD

Inventor： MAROM EHUD ,  MIZHIRITSKII MICHAEL ,  RUBNOV SHAI

IPC: C07C201/12 ,  C07C205/16 ,  C07C205/40 ,  C07C205/45 ,  C07C215/28 ,  C07C231/02 ,  C07D319/06 ,  C07F9/40 ,  C07F9/54

CPC classification number: C07C213/02 ,  C07C201/12 ,  C07C205/02 ,  C07C205/31 ,  C07C205/40 ,  C07C205/45 ,  C07C231/02 ,  C07D319/06 ,  C07F9/4021 ,  C07F9/4056 ,  C07F9/5442 ,  C07F9/5456 ,  C07C215/28 ,  C07C205/16

Abstract: The present invention relates to processes for the preparation of (2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (Fingolimod) and pharmaceutically acceptable salts thereof, and intermediates formed in such processes.

Abstract translation: 本发明涉及制备（2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇盐酸盐（芬戈莫德）及其药学上可接受的盐的方法，以及在这些方法中形成的中间体 。

公开(公告)号：EP2298749B1

公开(公告)日：2014-12-24

申请号：EP10177806.6

申请日：1999-05-04

Applicant: BASF SE

Inventor： Rheinheimer, Joachim ,  von Deyn, Wolfgang ,  Gebhardt, Joachim ,  Rack, Michael ,  Lochtman, Rene ,  Götz, Norbert ,  Keil, Michael ,  Witschel, Matthias ,  Hagen, Helmut ,  Mißlitz, Ulf ,  Baumann, Ernst

IPC: C07D261/04 ,  C07D413/10 ,  C07C251/40 ,  C07C319/14

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

公开(公告)号：EP2054365B1

公开(公告)日：2014-09-24

申请号：EP07763806.2

申请日：2007-07-06

Applicant: Uniban - Universidade Bandeirante De São Paulo ,  Fundação de Amparo à Pesquisa de São Paulo-FAPESP

Inventor： SUÁREZ, José, Agustín, Quincoces ,  MARIA, Durvanei, Augusto ,  RANDO, Daniela, Gonçales ,  MARTINS, Clizete, Aparecida, Sbravate ,  PARDI, Paulo, Celso ,  DE SOUZA, Pamela, Oliveira

IPC: C07C45/64 ,  C07C45/69 ,  C07C45/74 ,  C07C49/223 ,  C07C49/603 ,  A61K31/121 ,  A61K31/122 ,  C07C201/12 ,  C07C253/30 ,  C07C255/46 ,  C07C205/45 ,  C07C205/37 ,  C07C49/255 ,  C07C255/37

CPC classification number: C07C255/37 ,  C07C45/64 ,  C07C49/255 ,  C07C51/367 ,  C07C59/90 ,  C07C67/14 ,  C07C69/78 ,  C07C201/12 ,  C07C205/37 ,  C07C205/45 ,  C07C253/30 ,  C07C2601/14 ,  C07C255/46

公开(公告)号：EP2474536B1

公开(公告)日：2014-06-25

申请号：EP10811488.5

申请日：2010-08-23

Applicant: Ihara Chemical Industry Co., Ltd.

Inventor： KAWAZOE, Kentaro

IPC: C07D239/52 ,  C07C201/08 ,  C07C201/12 ,  C07C205/26 ,  C07C205/34 ,  C07C205/58 ,  C07C205/19

CPC classification number: C07D239/52 ,  C07C201/08 ,  C07C201/12 ,  C07C205/19 ,  C07C205/34 ,  C07C205/58

公开(公告)号：EP2417119A4

公开(公告)日：2014-05-21

申请号：EP10761972

申请日：2010-04-01

Applicant: UNIV CALIFORNIA

Inventor： SATYAMURTHY NAGICHETTIAR ,  BARRIO JORGE R

IPC: C07D319/06 ,  C07B59/00 ,  C07C201/12 ,  C07C205/11 ,  C07C227/16 ,  C07C229/36 ,  C07D233/32 ,  C07D239/10 ,  C07D241/08 ,  C07D263/04 ,  C07D263/18 ,  C07D405/12 ,  C07D413/12

CPC classification number: C07D319/06 ,  C07B59/00 ,  C07B2200/05 ,  C07C201/12 ,  C07C227/16 ,  C07C229/36 ,  C07D233/32 ,  C07D241/08 ,  C07D263/18 ,  C07D405/12 ,  C07D413/12 ,  C07C205/11

公开(公告)号：EP2703381A1

公开(公告)日：2014-03-05

申请号：EP12777023.8

申请日：2012-04-27

Applicant: Ono Pharmaceutical Co., Ltd.

Inventor： HAYASHI, Yujiro

IPC: C07C205/18 ,  C07C201/12 ,  C07C205/44 ,  C07D307/42 ,  C07B53/00 ,  C07B61/00

CPC classification number: C07D307/45 ,  C07B53/00 ,  C07C67/30 ,  C07C69/732 ,  C07C69/738 ,  C07C201/12 ,  C07C205/05 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/42 ,  C07C205/18 ,  C07C205/44 ,  C07C205/41 ,  C07C205/55

Abstract: The present invention provides a method that allows production of stereospecific and asymmetrical five-membered ring-containing compounds serving as synthetic intermediates for formation of five-membered rings of prostaglandins and the like, with high yield and excellent stereoselectivity in terms of diastereoselectivity and enantioselectivity in a short process without requiring troublesome procedures such as optical resolution. The method for producing a five-membered ring-containing compound includes a cyclization step of condensing and cyclizing an α, β-unsaturated nitro compound represented by the following chemical formula (I) with a 1,4-butanedione compound, in the presence of a catalyst formed by a compound having a pyrrolidine ring and an optically active α-carbon relative to the nitrogen on the ring, in a water-insoluble organic solvent and/or a non-oxygen atom-containing water-soluble organic solvent so as to produce the five-membered ring-containing compound represented by the following chemical formula (II).