公开(公告)号：EP3316883A1

公开(公告)日：2018-05-09

申请号：EP15897348.7

申请日：2015-06-30

申请人： University of South Florida

发明人： SABBAGH, Jonathan Jacob ,  DICKEY, Chad

IPC分类号： A61K31/439 ,  A61K31/415 ,  A61K31/445 ,  A61K31/498 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K31/5415 ,  A61K31/4168 ,  A61K31/454 ,  A61K31/46 ,  A61K45/06 ,  A61K2300/00

摘要： The subject invention concerns materials and methods for treating depression, stress disorders, such as PTSD, anxiety disorders, and/or a neurodegenerative disease or condition in a person or animal. In one embodiment, a person or animal in need of treatment is administered one or more compounds or drugs, or a composition comprising the one or more compounds or drugs, that inhibit FKBP51 activity or function. The subject invention also concerns a method for inhibiting activity of the FKBP51 protein in a cell. The subject invention also concerns methods of screening for compounds or drugs that inhibit the FKBP51 protein.

公开(公告)号：EP2440967B1

公开(公告)日：2018-03-21

申请号：EP10785617.1

申请日：2010-06-10

申请人： Switch Materials, Inc.

发明人： LAM, Duhane ,  BRANDA, Neil, R. ,  SPANTULESCU, Andrea

IPC分类号： G02F1/15 ,  G02B5/20

CPC分类号： G02F1/163 ,  B60J3/04 ,  G02B5/223 ,  G02B5/23 ,  G02C7/101 ,  G02C7/102 ,  G02F1/0018 ,  G02F1/0063 ,  G02F1/15 ,  G02F1/1533 ,  G02F1/157 ,  G02F2001/1515 ,  G02F2201/086 ,  H01R43/26 ,  Y10T29/49117 ,  Y10T29/49204 ,  Y10T156/10

摘要： Variable transmittance optical filters capable of transitioning from a light state to a dark state on exposure to UV radiation and from a dark state to a light state with application of an electric voltage are provided. The optical filters comprise a switching material that comprises one or more chromophores that have electrochromic and photochromic properties.

公开(公告)号：EP3242137A1

公开(公告)日：2017-11-08

申请号：EP15875173.5

申请日：2015-12-24

申请人： W.H.P.M. Bioresearch and Technology Co., Ltd.

发明人： WAN, John ,  ZOU, Chunhai ,  XIA, Qinghai ,  LIU, Jie

IPC分类号： G01N35/04

CPC分类号： G01N35/04 ,  A61B10/0038 ,  G01N33/4833 ,  G01N2035/0439

摘要： The present invention provides a fully automatic fecal occult blood detecting analyzer, which is used to detect a sample box (30). The sample box (30) includes a transparent sleeve and a feces collector and test strips provided in the transparent sleeve. The fully automatic fecal occult blood detecting analyzer includes a feeding chain (10) and a main conveying chain (20); a plurality of clamping devices (40) for clamping the sample box (30) are provided on the feeding chain (10) and the main conveying chain (20), respectively; a transferring device is configured to transfer the sample box (30) from the feeding chain (10) to the main conveying chain (20); a pressing device (90); and an image acquisition device is configured to acquire colored tape information presented on the test strips in the sample box (30) on the main conveying chain (20). The present invention can implement continuous detection and accurate location of a plurality of sample boxes (30) without turning over and tilting the sample boxes (30). Besides, the sample boxes (30) can be pressed accurately so that diluents of fecal samples react with test strips to complete detection.

摘要翻译： 本发明提供了一种全自动粪便隐血检测分析仪，用于检测样品盒（30）。 样品盒（30）包括透明套管和粪便收集器以及设置在透明套管中的测试条。 该全自动大便隐血检测分析仪包括进料链（10）和主输送链（20）; 在输送链（10）和主输送链（20）上分别设有多个用于夹紧样品盒（30）的夹紧装置（40） 传送装置构造成将样本盒（30）从馈送链（10）传送到主传送链（20）; 一个压紧装置（90）; 并且图像获取装置被配置为获取呈现在主输送链（20）上的样本箱（30）中的测试条上的彩色带信息。 本发明可以实现多个样品盒（30）的连续检测和精确定位，而不会翻转和倾斜样品盒（30）。 此外，可以精确地按压样本盒（30），使得粪便样本的稀释液与测试条反应以完成检测。

公开(公告)号：EP2791177B1

公开(公告)日：2017-09-06

申请号：EP12806641.2

申请日：2012-12-14

申请人： Janssen Pharmaceuticals, Inc.

发明人： HUNTINGTON, James Andrew ,  BAGLIN, Trevor ,  LANGDOWN, Jonathan

IPC分类号： C07K16/40 ,  C07K16/36

CPC分类号： C07K16/40 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP3132034A1

公开(公告)日：2017-02-22

申请号：EP15718982.0

申请日：2015-04-14

申请人： Nemesis Bioscience Ltd.

发明人： MIKAWA, Yoshikazu ,  LICHTENSTEIN, Conrad

IPC分类号： C12N15/09

摘要： The invention encompasses recombinant polynucleotides, compositions and methods for interfering with antibiotic resistance genes, and/or replicons carrying such genes, in microorganisms in order to disable antibiotic resistance in the microorganisms, using a clustered regularly interspaced short palindromic repeat (CRISPR) array system.

摘要翻译： 本发明包括用微生物干扰抗生素抗性基因和/或携带这些基因的复制子的重组多核苷酸，组合物和方法，以便使用聚集的规则间隔的短回文重复（CRISPR）阵列系统来抑制微生物中的抗生素抗性。

公开(公告)号：EP3123860A1

公开(公告)日：2017-02-01

申请号：EP15767882.2

申请日：2015-03-24

申请人： Kingstronbio (Changshu) Co., Ltd.

发明人： ZHONG, Shengping Sam ,  LIU, Jing

IPC分类号： A01N1/00 ,  A61F2/24

CPC分类号： A01N1/021 ,  A01N1/0215 ,  A61F2/2415 ,  A61F2/2427 ,  A61F2220/0075

摘要： The present invention provides an acellular collagenous tissue and a method for processing an artificial heart valve containing the acellular collagenous tissue. The method comprises immersing the acellular collagenous tissue in a preservation liquid containing an ionic liquid until the size of the acellular collagenous tissue remains stable in a non-liquid environment. The present invention also provides a preservation method, comprising immersing the acellular collagenous tissue or the artificial heart valve containing acellular collagenous tissue in the preservation liquid containing ionic liquid until the size of the collagen tissue remains stable in the non-liquid environment, and after taking out the acellular collagenous tissue or the artificial heart valve containing the acellular collagenous tissue, removing the excessive preservation liquid adhered to a surface thereof , and packaging the acellular collagenous tissue or the artificial heart valve. The present invention also provides an acellular collagenous tissue and an artificial heart valve containing the acellular collagenous tissue processed by the method described above. The method provided by the present invention can effectively avoid a biological material damage caused by being in a non-liquid environment and is beneficial to implement a subsequent processing and sterilization for the biological material.

摘要翻译： 本发明提供了一种无细胞胶原组织和用于处理含有无细胞胶原组织的人造心脏瓣膜的方法。 该方法包括将无细胞胶原组织浸入含有离子液体的保存液中，直到无细胞胶原组织的大小在非液体环境中保持稳定。 本发明还提供了一种保存方法，包括将含有无细胞胶原组织的无细胞胶原组织或人造心脏瓣膜浸入含有离子液体的保存液中，直到胶原组织的尺寸在非液体环境中保持稳定，并且在服用 脱离无细胞胶原组织或含有无细胞胶原组织的人造心脏瓣膜，去除附着在其表面上的过量保存液体，以及包封无细胞胶原组织或人造心脏瓣膜。 本发明还提供一种无细胞胶原组织和含有通过上述方法处理的无细胞胶原组织的人造心脏瓣膜。 本发明提供的方法可以有效地避免由于处于非液体环境而引起的生物材料损害，有利于实现生物材料的后续加工和灭菌。

公开(公告)号：EP3096775A1

公开(公告)日：2016-11-30

申请号：EP15741027.5

申请日：2015-01-23

申请人： University of Florida Research Foundation, Inc.

发明人： JOHNSON, Howard, M. ,  LARKIN, Joseph ,  AHMED, Chulbul, M. ,  JAGER, Lindsey

IPC分类号： A61K38/17 ,  C07K14/435 ,  C12N15/63 ,  C12Q1/68

CPC分类号： C07K7/08 ,  A61K9/0014 ,  A61K9/127 ,  A61K31/138 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/506 ,  A61K31/513 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/10 ,  A61K38/17 ,  A61K45/06 ,  C07K14/4718 ,  C12Q1/6883 ,  C12Q2600/158 ,  A61K2300/00

摘要： The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and a SOCS3 target protein. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51, or a functional fragment or variant thereof. In a further embodiment, a peptide of the invention can comprise multiple copies of the mimetic sequence. In one embodiment, a peptide of the invention comprises two or more copies of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:3 and/or SEQ ID NO:4 and/or SEQ ID NO:52, or a functional fragment or variant thereof. The subject invention also pertains to methods of treating and/or preventing autoimmune conditions and/or disorders. In one embodiment, one or more peptide mimetics of the invention are used to treat an autoimmune condition or disorder in a person or animal. In a specific embodiment, a mimetic of the invention is used to treat SLE in a person or animal. The subject invention also concerns methods for diagnosing and/or monitoring progression of SLE in a person or animal.

摘要翻译： 本发明涉及SOCS蛋白质的肽模拟物和使用方法。 在一个实施方案中，本发明的肽模拟物结合SOCS1和SOCS3靶蛋白。 在具体实施方案中，本发明的肽模拟物包含SEQ ID NO：1和/或SEQ ID NO：2和/或SEQ ID NO：51的氨基酸序列或其功能片段或变体。 在另一个实施方案中，本发明的肽可以包含模拟序列的多个拷贝。 在一个实施方案中，本发明的肽包含SEQ ID NO：1和/或SEQ ID NO：2和/或SEQ ID NO：51的两个或多个拷贝。 在具体实施方案中，本发明的肽模拟物包含SEQ ID NO：3和/或SEQ ID NO：4至/或SEQ ID NO：52的氨基酸序列或其功能片段或变体。 本发明还涉及治疗和/或预防自身免疫病症和/或病症的方法。 在一个实施方案中，本发明的一种或多种肽模拟物用于治疗人或动物的自身免疫病症或病症。 在具体实施方案中，本发明的模拟物用于治疗人或动物中的SLE。 本发明还涉及用于诊断和/或监测人或动物中SLE进展的方法。

公开(公告)号：EP2545162B1

公开(公告)日：2016-10-19

申请号：EP11754213.4

申请日：2011-03-11

申请人： Research Corporation Technologies

发明人： BRAMHILL, David ,  MAMAT, Uwe

IPC分类号： C12N1/20

CPC分类号： C12N15/70 ,  C12N15/1037 ,  C12N15/78 ,  C12P19/34 ,  C12P21/02 ,  C40B40/02

公开(公告)号：EP3026130A1

公开(公告)日：2016-06-01

申请号：EP15196464.0

申请日：2015-11-26

申请人： Lifezone Limited

发明人： LIDDELL, Keith Stuart ,  SMITH, Lisa Anne ,  ADAMS, Michael David

IPC分类号： C22B3/20 ,  C22B11/06

CPC分类号： C22B3/08 ,  C01B7/0706 ,  C01B7/0712 ,  C01B7/0718 ,  C22B3/10 ,  C22B3/20 ,  C22B11/04 ,  C22B11/06 ,  C22B15/0069 ,  C22B15/0071 ,  C22B23/0423 ,  C22B23/043 ,  C25C1/20 ,  Y02P10/234

摘要： This invention describes a hydrometallurgical process for the recovery and separation of valuable elements, in particular gold and silver, from a feed material comprising a refractory, intractable or otherwise poorly responding to conventional treatment routes ores, concentrates and other materials. In particular, the process is a process integrated into one or more existing value element extraction processes.

摘要翻译： 本发明描述了一种用于回收和分离有价值元素，特别是金和银的湿法冶金方法，该原料包括耐火材料，难处理或其他对常规处理途径矿石，浓缩物和其它材料的响应不佳的进料。 特别地，该过程是集成到一个或多个现有价值元素提取过程中的过程。

公开(公告)号：EP2866723A1

公开(公告)日：2015-05-06

申请号：EP13809980.9

申请日：2013-03-15

申请人： Monteris Medical Corporation

发明人： TYC, Richard ,  QURESHI, Salman ,  GRANT, Mark Andrew ,  FERNANDES, Luis Filipe Silva ,  CARREIRA, Daniel Prazeres ,  SCHELLHORN, John

IPC分类号： A61B19/00

CPC分类号： A61B18/22 ,  A61B5/015 ,  A61B5/055 ,  A61B5/4839 ,  A61B5/742 ,  A61B5/746 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/06 ,  A61B18/148 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/28 ,  A61B34/20 ,  A61B34/25 ,  A61B34/71 ,  A61B90/10 ,  A61B90/11 ,  A61B90/14 ,  A61B2017/00017 ,  A61B2017/00911 ,  A61B2017/3407 ,  A61B2018/00017 ,  A61B2018/00023 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61B2018/0212 ,  A61B2018/0293 ,  A61B2018/1807 ,  A61B2018/1861 ,  A61B2018/20351 ,  A61B2018/2211 ,  A61B2018/2261 ,  A61B2034/107 ,  A61B2034/2068 ,  A61B2034/301 ,  A61B2090/061 ,  A61B2090/374 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/022 ,  G01R33/285 ,  G01R33/4804

摘要： Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient.