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21.发明公开
公开(公告)号：EP3460048A1
公开(公告)日：2019-03-27
申请号：EP18195142.7
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
发明人： Lobocka, Malgorzata , Hejnowicz, Monika , Dabrowski, Kamil , Izak, Dariusz , Gozdek, Agnieszka , Glowacka, Aleksandra , Gawor, Jan , Kosakowski, Jaroslaw , Gromadka, Robert , Weber-Dabrowska, Beata , Górski, Andrzej
摘要： Disclosed are Staphylococcus aureus strains for obtaining monoclonal preparations of lytic bacteriophages with high titer, devoid of contamination with undesired bacteriophages and plasmid DNA, which guarantee the production of safe to use bacteriophage preparations, not being a source of dissemination of genes associated with bacterial virulence.
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22.发明公开
公开(公告)号：EP3448410A1
公开(公告)日：2019-03-06
申请号：EP17733517.1
申请日：2017-04-28
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23.发明授权METHOD FOR SELECTION OF HDIS3 PIN DOMAIN INHIBITORS AND USE OF HDIS3 PIN DOMAIN INHIBITORS FOR CANCER TREATMENT 有权HDIS3 PIN结构域抑制剂的选择及HDIS3 PIN域抑制剂为癌症治疗
公开(公告)号：EP2999789B1
公开(公告)日：2017-05-10
申请号：EP14733705.9
申请日：2014-05-20
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , ONCOARENDI THERAPEUTICS SP. Z.O.O. , Miedzynarodowy Instytut Biologii Molekularnej I Komorkowej
发明人： DZIEMBOWSKI, Andrzej , TOMECKI, Rafal , DRAZKOWSKA, Karolina , SZCZESNY, Roman , STODUS, Krystian , JONKO, Weronika , NOWOTNY, Marcin , GOLEBIOWSKI, Adam , OLCZAK, Jacek
IPC分类号： C12N15/81
CPC分类号： C12Q1/6897 , A61K31/472 , C12N15/81 , C12Q1/18 , G01N33/5008 , G01N33/5011 , G01N33/5038 , G01N33/573 , G01N2333/916 , G01N2333/922 , G01N2500/04 , G01N2500/10
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24.发明公开METHOD FOR SYNTHESIS OF A BIOPOLYMER DERIVATIVE, A BIOPOLYMER DERIVATIVE AND ITS USE 审中-公开合成生物聚合物衍生物，生物聚合物衍生物及其用途的方法
公开(公告)号：EP3107941A1
公开(公告)日：2016-12-28
申请号：EP15715502.9
申请日：2015-02-19
发明人： BAL, Wojciech , ZAWISZA, Izabela , FRACZYK, Tomasz
IPC分类号： C08B37/08 , A61K31/722 , A61K47/36 , A61K38/06 , C07K5/02 , A61L27/20 , C08L5/08 , C09D105/08 , A61P17/00
CPC分类号： A61K47/4823 , A61K8/736 , A61K9/0014 , A61K9/06 , A61K31/431 , A61K31/722 , A61K38/063 , A61K38/12 , A61K47/36 , A61K47/61 , A61K2800/51 , A61K2800/57 , A61Q19/00 , C07K1/1077 , C07K5/0215 , C07K17/10 , C08B37/003 , C08H1/00 , C08L5/08 , C09D105/08 , C22B3/44 , C22B23/0461
摘要： The invention relates to a method of synthesis of a biopolymer derivative, preferably a chitosan derivative, comprising the formation of a peptide bond. The invention also relates to the biopolymer derivative, and use of the biopolymer derivative, preferably a chitosan derivative. The biopolymer derivative has broad uses in the industry, environmental protection and can be used in pharmaceutical and cosmetic compositions. The invention also relates to a composition for prevention of symptoms of allergy caused by heavy metals, especially palladium, cobalt, chromium and gold, in particular nickel.
摘要翻译： 本发明涉及合成生物聚合物衍生物，优选壳聚糖衍生物的方法，包括形成肽键。 本发明还涉及生物聚合物衍生物，以及生物聚合物衍生物，优选壳聚糖衍生物的用途。 生物聚合物衍生物在工业中具有广泛的用途，环境保护并且可以用于药物和化妆品组合物中。 本发明还涉及用于预防由重金属，尤其是钯，钴，铬和金，特别是镍引起的过敏症状的组合物。
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25.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开作为突变CFTR蛋白调节剂的化合物及其用于治疗与CFTR蛋白功能失调相关的疾病的用途
公开(公告)号：EP2816035A3
公开(公告)日：2015-02-25
申请号：EP14185333.3
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
摘要翻译： 本发明涉及能够改变突变CFTR蛋白功能的新颖蛋白调节剂及其用于治疗与CFTR蛋白功能失调有关的疾病的用途。 本发明提供了校正突变CFTR蛋白的细胞改变的组合物，药物制剂和方法，其中CFTR突变是ΔF508-CFTR突变或II类另一突变。
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公开(公告)号：EP3186361B1
公开(公告)日：2019-06-05
申请号：EP15778720.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
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公开(公告)号：EP3105350B1
公开(公告)日：2019-04-10
申请号：EP15712187.2
申请日：2015-02-12
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Warszawski Uniwersytet Medyczny , Uniwersytet Medyczny W Bialymstoku
发明人： BURZYNSKA, Beata , GÓRA, Monika , MACIEJAK, Agata , TULACZ, Dorota , KILISZEK, Marek , MICHALAK, Marcin , OPOLSKI, Grzegorz , MATLAK, Krzysztof , DOBRZYCKI, Slawomir
IPC分类号： C12Q1/6883
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公开(公告)号：EP3456813A1
公开(公告)日：2019-03-20
申请号：EP18195200.3
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
发明人： Lobocka, Malgorzata , Gozdek, Agnieszka , Izak, Dariusz , Zalewska, Agnieszka , Gawor, Jan , Dabrowski, Kamil , Gromadka, Robert , Weber-Dabrowska, Beata , Górski, Andrzej
摘要： Disclosed are Enterococcus faecalis strains for obtaining monoclonal preparations of lytic bacteriophages with high titer, particularly devoid of contamination with undesired bacteriophages, the strains guaranteeing the production of safe to use bacteriophage preparations, not being a source of dissemination of genes associated with bacterial virulence.
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公开(公告)号：EP2816034B1
公开(公告)日：2018-12-12
申请号：EP14185332.5
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D473/22 , C07D401/12 , C07C235/84 , A61K31/496 , A61K31/52
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ”F508-CFTR, or another mutation of class II.
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公开(公告)号：EP2872156B1
公开(公告)日：2017-08-09
申请号：EP13741984.2
申请日：2013-07-13
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk , Narodowy Instytut Leków , Szkola Glówna Gospodarstwa Wiejskiego W Warszawie , Wojskowy Instytut Higieny I Epidemiologii
发明人： LOBOCKA, Malgorzata , GLOWACKA, Aleksandra , DABROWSKI, Kamil , HEJNOWICZ, Monika S. , GOZDEK, Agnieszka , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej , EMPEL, Joanna , HRYNIEWICZ, Waleria , KWIATEK, Magdalena , PARASION, Sylwia , GRYKO, Romuald
IPC分类号： A61K35/76
CPC分类号： G01N33/5085 , A61K35/76 , G01N2333/4353 , Y02A50/475 , Y02A50/481
摘要： The subject of the present invention is a novel use of a nematode in the evaluation of the therapeutic efficacy of bacteriophage preparations used in, or capable of being used in the treatment of infections caused by pathogenic bacteria in humans or animals.
摘要翻译： 本发明的主题是线虫在评价用于或能够用于治疗由人或动物中的致病细菌引起的感染的噬菌体制剂的治疗功效中的新用途。
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