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    CATALYST AND USE OF SAME
    22.
    发明公开
    CATALYST AND USE OF SAME 审中-公开

    公开(公告)号：EP3427826A1

    公开(公告)日：2019-01-16

    申请号：EP17763083.7

    申请日：2017-03-02

    Applicant: Japan Science and Technology Agency

    Inventor： YAMAUCHI Miho ,  SADAKIYO Masaaki ,  KITANO Sho ,  HATA Shinichi

    IPC: B01J35/02

    Abstract: An electrochemical catalyst includes a titanium oxide having an anatase-type crystal structure, in which in a single titanium oxide particle, a vertex density per unit surface area is 8.0 × 10 -4 nm -2 or more, or a vertex density per unit volume is 7.0 × 10 -4 nm -3 or more, and a ridge line density per unit surface area is 5.0 × 10 -2 nm -1 or more, or a ridge line density per unit volume is 8.0 × 10 -3 nm -2 or more. A cathode includes the electrochemical catalyst which is carried on at least a surface. A membrane electrode assembly for alcohol synthesis includes an anode, the cathode, and an electrolyte membrane between the anode and the cathode.

    METHOD AND DEVICE FOR VISUALIZING DISTRIBUTION OF LOCAL ELECTRIC FIELD
    26.
    发明授权
    METHOD AND DEVICE FOR VISUALIZING DISTRIBUTION OF LOCAL ELECTRIC FIELD 有权

    公开(公告)号：EP2259051B1

    公开(公告)日：2018-10-10

    申请号：EP09720348.3

    申请日：2009-03-13

    Applicant: Japan Science and Technology Agency

    Inventor： FUJITA, Jun-ichi

    IPC: G01N23/225

    CPC classification number: G01N23/2251 ,  G01N23/2206 ,  H01J2237/244

    Abstract: A method which visualizes the distribution of a local electric field formed near a sample 2 is disclosed. A primary electron beam 1 which passes through the local electric field formed near the sample 2 is deflected by the local electric field, secondary electrons which are generated and emitted from a detection element provided downstream of an orbit of the deflected primary electron beam 1 are detected by a secondary electron detector 6, and an image formed based on the detected signal and a scanning electron beam image obtained by scanning the sample 2 are synthesized thus visualizing the distribution of the local electric field in multiple tones. Due to such an operation, it is possible to provide a method for visualizing the distribution of a local electric field in which the distribution of a local electric field can be obtained in multiple tone and in real time by performing image scanning one time using a usual electron beam scanning optical system.

    DYNAMIC MODE AFM APPARATUS
    27.
    发明授权
    DYNAMIC MODE AFM APPARATUS 有权

    公开(公告)号：EP2275798B1

    公开(公告)日：2018-08-29

    申请号：EP09746445.7

    申请日：2009-04-08

    Applicant: Japan Science and Technology Agency

    Inventor： KAWAKATSU, Hideki ,  KOBAYASHI, Dai

    IPC: G01Q60/34

    CPC classification number: G01Q60/34

    Abstract: There is provided a dynamic mode AFM apparatus that configures an automatic control system which can automatically obtain a probe-sample distance, and allows high-speed identification of atoms of the sample surface. The dynamic mode AFM apparatus comprises: a scanner 3 for performing three-dimensional relative scanning of a cantilever 2 and a sample 1; a means 8 for generating an AC signal of a resonance frequency in a mode with flexural vibration of the cantilever 2; a means 9 for exciting the flexural vibration of the cantilever 2 with the resonance frequency; a means 10 for generating an AC signal of a second frequency which is lower than the frequency of the flexural vibration; a means 11 for modulating a probe 2A-sample 1 distance of the cantilever 2 with the second frequency; a means 5 for detecting fluctuation of the resonance frequency; a means 4 for detecting vibration of the cantilever; and a means 6 for detecting a fluctuation component which is contained in a detected signal by the means 5 for detecting the resonance frequency fluctuation and synchronized with a modulation signal of the probe 2A-sample 1 distance, wherein an inclination of the resonance frequency against the probe 2A-sample 1 distance is obtained from the strength and polarity of the fluctuation component.

    TUMOR CELL MALIGNANT TRANSFORMATION SUPPRESSOR AND ANTI-TUMOR AGENT
    29.
    发明公开
    TUMOR CELL MALIGNANT TRANSFORMATION SUPPRESSOR AND ANTI-TUMOR AGENT 审中-公开
    肿瘤细胞恶性转化抑制剂和抗肿瘤药物

    公开(公告)号：EP3290054A1

    公开(公告)日：2018-03-07

    申请号：EP16789510.1

    申请日：2016-04-22

    Applicant: Japan Science and Technology Agency

    Inventor： FUKAMI Kiyoko ,  SATOW Reiko

    IPC: A61K45/00 ,  A61K31/713 ,  A61K48/00 ,  A61P13/08 ,  A61P17/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00

    CPC classification number: A61K31/713 ,  A61K45/00 ,  A61K48/00 ,  C07K14/4702 ,  C12N15/1135 ,  C12N2310/14

    Abstract: The present invention provides an anti-tumor agent and a suppressor for suppressing malignant transformation such as acquisition of metastatic ability or acquisition of apoptosis resistance of a tumor cell. The present invention provides a tumor cell malignant transformation suppressor, including a substance suppressing or inhibiting Zic5 gene functions as an active ingredient to suppress or inhibit acquisition of metastatic ability or acquisition of apoptosis resistance of a tumor cell; a method of suppressing tumor cell malignant transformation of animals other than humans, including suppressing or inhibiting Zic5 gene functions to suppress or inhibit acquisition of metastatic ability or acquisition of apoptosis resistance of a tumor cell; an anti-tumor agent including a substance suppressing or inhibiting Zic5 gene functions as an active ingredient, in which the agent is used in prostate cancer therapy; and a marker for tumor cell malignancy consisting of the expression level of Zic5 gene.

    Abstract translation: 本发明提供用于抑制肿瘤细胞的转移能力的获得或获得抗细胞凋亡的恶性转化的抗肿瘤剂和抑制剂。 本发明提供肿瘤细胞恶性转化抑制剂，其包括抑制或抑制Zic5基因功能的物质作为活性成分以抑制或抑制肿瘤细胞的转移能力的获得或获得细胞凋亡抗性; 抑制人以外的动物的肿瘤细胞恶性转化的方法，包括抑制或抑制Zic5基因功能以抑制或抑制获得转移能力或获得肿瘤细胞的细胞凋亡抗性; 包含抑制或抑制Zic5基因的物质作为活性成分的抗肿瘤剂，其中所述药物用于前列腺癌治疗; 和由Zic5基因表达水平组成的肿瘤细胞恶性肿瘤标志物。

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