公开(公告)号：EP1007042A4

公开(公告)日：2001-07-04

申请号：EP98929059

申请日：1998-06-12

申请人： SUGEN INC

发明人： TANG PENG CHO ,  MCMAHON GERALD ,  RAMPHAL JOHN Y

IPC分类号： C07D277/20 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/424 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/55 ,  A61P3/10 ,  A61P9/00 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D277/58 ,  C07D277/70 ,  C07D403/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/08 ,  C07D473/24 ,  C07D475/02 ,  C07D487/04 ,  C07D498/04 ,  C07D403/12 ,  A61K31/495

CPC分类号： C07D409/12 ,  C07D417/12 ,  C07D417/14

公开(公告)号：EP0769947B1

公开(公告)日：2001-05-02

申请号：EP96918093.4

申请日：1996-06-05

申请人： Sugen, Inc.

发明人： TANG, Peng Cho ,  SUN, Li ,  MCMAHON, Gerald

IPC分类号： A61K31/40 ,  C07C209/34 ,  C07D209/34

CPC分类号： C07D403/06 ,  C07D209/34 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

公开(公告)号：EP0979288A2

公开(公告)日：2000-02-16

申请号：EP98919919.5

申请日：1998-04-27

申请人： Sugen, Inc.

发明人： PLOWMAN, Greg, D. ,  CLARY, Douglas ,  JALLAL, Bahija ,  PELES, Elior ,  ONRUST, Susan ,  MARKBY, Dave ,  COURTNEIDGE, Sara, A. ,  APP, Harald ,  HUI, Terance, H.

IPC分类号： C12N15/54 ,  C12N15/55 ,  C12N9/12 ,  C12N9/16 ,  C07K14/705 ,  C12N15/11 ,  C07K16/40 ,  C07K16/28 ,  C12N5/12 ,  C12N15/62 ,  C12Q1/42 ,  C12Q1/48

CPC分类号： C12N9/1205 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/16

摘要： The present invention relates to phosphatases and kinases, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for phosphatase- or kinase-related diseases or conditions characterized by an abnormal interaction between a phosphatase or a kinase and its binding partner.

公开(公告)号：EP0954315A2

公开(公告)日：1999-11-10

申请号：EP97941542.0

申请日：1997-09-11

申请人： Sugen, Inc.

发明人： McMAHON, Gerald ,  SHAWVER, Laura, Kay ,  NAROG, Blair ,  TANG, Peng, Cho ,  HIRTH, Klaus, Peter

IPC分类号： A61K9 ,  A61K31 ,  A61K47 ,  C07D239

CPC分类号： A61K9/0014 ,  A61K31/517 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  C07D239/94

摘要： This invention is directed to methods and compositions for treating hyperproliferative skin disorders utilizing a quinazoline derivative as an active ingredient.

公开(公告)号：EP0948604A2

公开(公告)日：1999-10-13

申请号：EP97952333.0

申请日：1997-12-09

申请人： Sugen, Inc. ,  NEW YORK UNIVERSITY MEDICAL CENTER

发明人： LEV, Sima ,  SCHLESSINGER, Joseph

IPC分类号： C12N15 ,  C12N1 ,  C12N5 ,  C12N9 ,  G01N33

CPC分类号： C12N9/1205 ,  G01N33/566 ,  G01N2500/00

摘要： The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a PYK2 protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a PYK2 protein.

公开(公告)号：EP0934931A2

公开(公告)日：1999-08-11

申请号：EP99103667.4

申请日：1996-06-05

申请人： Sugen, Inc.

发明人： Tang, Peng Cho ,  Sun, Li ,  McMahon, Gerald

IPC分类号： C07D209/34

CPC分类号： C07D403/06 ,  C07D209/34 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to compounds of the formulae
wherein
X is Br, Cl, F or I;
wherein
Z is Br, Cl, F, I, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl or tert-butyl;
capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

摘要翻译： 本发明涉及下式的化合物：其中X是Br，Cl，F或I; 其中Z是Br，Cl，F，I，甲基，乙基，正丙基，异丙基，正丁基，异丁基或叔丁基; 能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖。

公开(公告)号：EP0931146A1

公开(公告)日：1999-07-28

申请号：EP97945311.0

申请日：1997-09-26

申请人： Sugen, Inc. ,  NEW YORK UNIVERSITY MEDICAL CENTER

发明人： LEV, Sima ,  PLOWMAN, Gregory, D. ,  SCHLESSINGER, Joseph

IPC分类号： C07K14 ,  C07K16 ,  C12N15

CPC分类号： C07K14/47 ,  C07K14/43545 ,  C07K14/43581 ,  C07K16/18

摘要： The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a rdgB protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a rdgB protein.

公开(公告)号：EP0832073A1

公开(公告)日：1998-04-01

申请号：EP96917174.0

申请日：1996-06-04

申请人： Sugen, Inc.

发明人： TANG, Peng, Cho ,  McMAHON, Gerald

IPC分类号： A61K31 ,  A61P35 ,  A61P43 ,  C07D239

CPC分类号： C07D239/74

摘要： The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities. The present invention also provides pharmaceutical compositions and methods for inhibiting cell proliferation of differentiation and related disorders. Examples of such disorders include cancers, blood vessel proliferative disorders, psoriasis, hyperimmune response and fibrotic disorders. Example ofother disorders include the HER2 disorders, EGF disorders, IGFR disorders, PDGFR disorders, met disorders, SrC disorders, and KDR/FLK-1 disorders described herein. It is to be understood that compounds which are effective for diseases related to one TK will also likely be effective for diseases related to other TK's, especially those from the same family. Thus, for example, compounds shown to have good effect against Her2 are likely to also have good effect against other members of the Her family, i.e., EGFR, Her3,and Her4.

公开(公告)号：EP2020408B1

公开(公告)日：2013-06-26

申请号：EP08165009.5

申请日：1999-05-28

申请人： Sugen, Inc.

发明人： Tang, Peng, Cho ,  Sun, Li ,  McMahon, Gerald

IPC分类号： C07D403/06 ,  A61K31/404 ,  A61P35/00

CPC分类号： C07D403/06 ,  C07D209/34

公开(公告)号：EP1603570B1

公开(公告)日：2013-01-23

申请号：EP04715001.6

申请日：2004-02-26

申请人： Sugen, Inc.

发明人： CUI, Jingjong, Jean ,  ZHANG, Jennifer ,  HANAU, Cathleen Elizabeth ,  BHUMRALKAR, Dilip ,  BOTROUS, Iriny ,  CHU, Ji Yu ,  FUNK, Lee A. ,  HARRIS Jr., G. Davis ,  JIA, Lei ,  JOHNSON, Joanne ,  KOLODZIEJ, Stephen A. ,  KUNG, Pei-Pei ,  LI, Xiaoyuan (Sharon) ,  LIN, Jason (Qishen) ,  MENG, Jerry Jialun ,  NAMBU, Mitchell David ,  NELSON, Christopher G. ,  PAIRISH, Mason Alan ,  SHEN, Hong ,  TRAN-DUBE, Michelle ,  WALTER, Allison ,  ZHANG, Fang-Jie

IPC分类号： A61K45/06 ,  C07D213/73 ,  A61K31/4965 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D211/72 ,  A61P35/00

CPC分类号： C07D213/73 ,  A61K45/06 ,  C07D401/12 ,  C07D413/12