-
公开(公告)号：EP1648475A2
公开(公告)日：2006-04-26
申请号：EP04777982.2
申请日：2004-07-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , UNIVERSITY OF ALABAMA RESEARCH FOUNDATION , LOMA LINDA UNIVERSITY , WAKE FOREST UNIVERSITY
发明人： GLADWIN, Mark, T. , SCHECHTER, Alan, N. , LEFER, David, J. , PATEL, Rakesh, P. , HUNTER, Christian J., National Inst. of Health , POWER, Gordon, G. , KIM-SHAPIRO, Daniel, B. , PLUTA, Ryszard National Institutes of Health NINDS , OLDFIELD, Edward, H.
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
-
22.发明授权USE OF PROLACTIN MODULATORS AND DIET FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF OBESITY 失效PROLACTINMODULATOREN和饮食用于生产药物中的肥胖治疗
公开(公告)号：EP0808164B1
公开(公告)日：2005-03-16
申请号：EP95907471.7
申请日：1995-01-06
申请人： PLIVA d.d. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/4985 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/15 , A61K31/166 , A61K31/195 , A61K31/221 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/405 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/475 , A61K31/48 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K38/2257 , A61K45/06 , G01N33/74 , Y10S514/866 , Y10S514/884 , Y10S514/909 , A61K2300/00
摘要： The present invention is directed to an improvement in a method of weight and/or body-fat reduction comprising a (preferably moderate) reduction in the caloric intake of a subject in need of such treatment in combination with administration to said subject of a prolactin inhibitor. Additionally, the present invention is directed to an improvement in a method for altering and/or resetting prolactin profiles (and thereby controlling one or more metabolic disorders such as obesity, excessive body fat, hyperlipidemia, hyperlipoproteinemia, hyperglycemia, hypercholesterolemia, hyperinsulinemia, insulin resistance, glucose intolerance, and Type II diabetes) comprising administration to a subject in need of such treatment of a prolactin inhibitor at a predetermined time or times during a 24-hour period in combination with a (preferably moderate) reduction of the caloric intake of said subject.
-
公开(公告)号：EP0833658B1
公开(公告)日：2003-03-26
申请号：EP96918234.4
申请日：1996-06-06
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K2039/6068 , C07K14/575 , C07K2319/00
摘要： The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.
-
公开(公告)号：EP0831819B1
公开(公告)日：2002-09-18
申请号：EP96921632.4
申请日：1996-06-05
申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , The General Hospital doing business as Massachusetts General Hospital
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , Y10S514/908 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
-
公开(公告)号：EP0093438A3
公开(公告)日：1985-04-17
申请号：EP83104249
申请日：1983-04-30
IPC分类号： A61K39/29
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , C12N2770/24234 , G01N33/5767
摘要： Non-A, non-B hepatitis antigen having a particle size of from about 2.0 to about 5.0 nm and a density of from about 1.24 to about 1.29 g/cc in CsCl. The foregoing antigen is isolated by isopycnic banding and chromatographic fractionation.
-
公开(公告)号：EP4460327A1
公开(公告)日：2024-11-13
申请号：EP23737802.1
申请日：2023-01-06
IPC分类号： A61K39/25 , A61K39/295 , A61K39/12 , C12N15/869 , C12N7/04
-
-
公开(公告)号：EP3194968A1
公开(公告)日：2017-07-26
申请号：EP15753250.8
申请日：2015-07-31
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N2333/03
摘要： Methods, compositions, devices, and kits are described herein that are useful for detecting BoHV-1 infection in animals and/or for distinguishing animals that may benefit from administration of BoHV-1 tmv vaccine.
摘要翻译： 本文描述的方法，组合物，装置和试剂盒可用于检测动物中的BoHV-1感染和/或区分可能受益于施用BoHV-1 tmv疫苗的动物。
-
公开(公告)号：EP2445535A2
公开(公告)日：2012-05-02
申请号：EP10792655.2
申请日：2010-06-24
发明人： LIU, Zhijun
IPC分类号： A61K47/36
摘要： Several terpene glycosides (e.g., mogroside V, paenoiflorin, geniposide, rubusoside, rebaudioside A, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, celecoxib, clofazimine, digoxin, oleandrin, nifedipine, and amiodarone. The use of the diterpene glycoside rubusoside and monoterpene glycoside paenoiflorin increased solubility in all tested compounds. The terpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries.
-
30.发明公开Vaccine against Ehrlichia canis and associated methods 审中-公开Impfstoff gegen Ehrlichia canis undzugehörigeVerfahren
公开(公告)号：EP2433646A1
公开(公告)日：2012-03-28
申请号：EP10178177.1
申请日：2010-09-22
申请人： Intervet International BV , The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
IPC分类号： A61K39/02
CPC分类号： A61K39/0233 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , C07K16/1246
摘要： Vaccine and/or immunogenic compositions that comprise an effective immunizing amount of an antigen from E. canis are described. In addition, methods of immunizing a subject against E. canis by providing the vaccine and/or immunogenic compositions are also disclosed.
摘要翻译： 描述了包含来自大肠杆菌的有效免疫量的抗原的疫苗和/或免疫原性组合物。 此外，还公开了通过提供疫苗和/或免疫原性组合物免疫受试者对犬蛔虫的方法。
-
-
-
-
-
-
-
-
-
搜索结果
53 条记录 (耗时 0.025 秒)
