公开(公告)号：EP3696536A1

公开(公告)日：2020-08-19

申请号：EP20167966.9

申请日：2016-04-14

申请人： Illumina, Inc.

发明人： BOWEN, M. Shane ,  YUAN, Dajun

IPC分类号： G01N21/64 ,  C12Q1/6874 ,  B81C1/00 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y20/00 ,  G03F7/00 ,  B82Y15/00 ,  C12Q1/6816 ,  C12Q1/6818 ,  G01N21/76 ,  G01N21/05

摘要： The present invention provides a method of manufacturing a structured substrate, the method comprising: providing a working substrate (522) having a side surface (524) and an array of reaction cavities (526), each of the reaction cavities (526) having an opening along the side surface (524) and extending a depth from the corresponding opening into the working substrate (522), the reaction cavities (526) coinciding with an array plane (525); and directing a deposition stream (536) onto the working substrate (522) at a non-orthogonal angle (544) with respect to the array plane (525), the deposition stream (536) including a plasmon resonant material, wherein the working substrate (522) forms a shadow area (558) and an incident area (560) in each reaction cavity (526) relative to a path of the deposition stream (536) such that the plasmon resonant material of the deposition stream (536) is blocked by the side surface (524) from being deposited onto the shadow area (558) and is permitted to pass through the opening and form along the incident area (560).

公开(公告)号：EP3458913A1

公开(公告)日：2019-03-27

申请号：EP17729244.8

申请日：2017-05-17

申请人： Illumina, Inc.

发明人： WU, Yir-Shyuan ,  LIN, Yan-You ,  BOWEN, M. Shane ,  DELATTRE, Cyril ,  ABEILLE, Fabien ,  KHURANA, Tarun ,  RIVAL, Arnaud ,  SABOUNCHI, Poorya ,  YUAN, Dajun ,  ROGERT BACIGALUPO, Maria Candelaria

IPC分类号： G03F7/40 ,  B82Y30/00 ,  C12Q1/68 ,  G01N33/52

公开(公告)号：EP3148697A1

公开(公告)日：2017-04-05

申请号：EP15729290.5

申请日：2015-05-27

申请人： Illumina, Inc.

发明人： ARAVANIS, Alex ,  BOYANOV, Boyan ,  BOWEN, M. Shane ,  BUERMANN, Dale ,  HSIAO, Alexander ,  JAVANMARDI, Behnam ,  KHURANA, Tarun ,  SABOUNCHI, Poorya ,  TRAN, Hai Quang

IPC分类号： B01L3/00 ,  B01L7/00

CPC分类号： B01L3/502715 ,  B01L3/502738 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0633 ,  B01L2400/0638 ,  B01L2400/0644 ,  B01L2400/065 ,  B01L2400/0655 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0028 ,  F16K2099/0074 ,  F16K2099/0084

摘要： Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

摘要翻译： 用于进行指定的反应利用碱仪器和可拆卸的标本盒的系统和方法。 可移盒体包括一流体网络没有接收和流体ausrichtet的生物样品以进行指定的反应。 因此，该可移盒体包括一流量控制阀也可操作地耦合到所述流体网络和相对于所述流体网络移动通过有控制所述生物样品的流动。 可移盒体被构造成可分离地接合底座仪器。 基座器械包括阀致动器确实地接合可移除的盒的流量控制阀。 由可移盒或底座仪器中的至少一个保持的检测组件可以被用于检测在指定的反应。

公开(公告)号：EP3814530A1

公开(公告)日：2021-05-05

申请号：EP19812891.0

申请日：2019-06-07

申请人： Illumina, Inc. ,  Illumina Cambridge Limited

发明人： FISHER, Jeffrey S. ,  MATHER, Brian D. ,  ROGERT BACIGALUPO, Maria Candelaria ,  FULLERTON, Justin ,  VINCENT, Ludovic ,  KRAFT, Lewis J. ,  HONG, Sahngki ,  BOYANOV, Boyan ,  BOWEN, M. Shane ,  PARK, Sang ,  GEORGE, Wayne N. ,  BROWN, Andrew A. ,  YUAN, Dajun

IPC分类号： C12Q1/6869 ,  C12N15/10 ,  C08F212/10 ,  C08F220/56 ,  C08F299/00 ,  C08G77/14 ,  G03F7/00

公开(公告)号：EP3801873A1

公开(公告)日：2021-04-14

申请号：EP20729843.1

申请日：2020-05-28

申请人： Illumina, Inc.

发明人： YUAN, Dajun ,  BOWEN, M. Shane ,  ZHONG, Mei

IPC分类号： B01J19/00 ,  B01L3/00

公开(公告)号：EP3366781B1

公开(公告)日：2020-10-28

申请号：EP18150783.1

申请日：2013-06-12

申请人： Illumina, Inc.

发明人： BOUTELL, Jonathan Mark ,  BOWEN, M. Shane ,  GUNDERSON, Kevin L. ,  RONAGHI, Mostafa ,  SHEN, Min-Jui Richard ,  STEPHENS, Kathryn M. ,  VENKATESAN, Bala Murali ,  VIJAYAN, Kandaswamy

IPC分类号： C12Q1/68 ,  G01N27/447

公开(公告)号：EP3283870B1

公开(公告)日：2020-05-06

申请号：EP16723559.7

申请日：2016-04-14

申请人： Illumina, Inc.

发明人： BOWEN, M. Shane ,  YUAN, Dajun

IPC分类号： G01N21/64 ,  C12Q1/6874 ,  C12Q1/6816 ,  C12Q1/6818 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y15/00 ,  G03F7/00 ,  G01N21/05 ,  G01N21/76

公开(公告)号：EP3577441A1

公开(公告)日：2019-12-11

申请号：EP18747995.1

申请日：2018-01-31

申请人： Illumina, Inc.

发明人： VIECELI, John S. ,  NEMIROSKI, Alex ,  BELITZ, Paul ,  LANGLOIS, Robert ,  BOWEN, M. Shane ,  CHAN, Danny Yuan ,  VENKATESAN, Bala Murali K. ,  HAN, Hui ,  SAMIEE, Kevan ,  TANNER, Stephen

IPC分类号： G01N21/64

公开(公告)号：EP2961524B1

公开(公告)日：2019-05-15

申请号：EP14710688.4

申请日：2014-02-21

申请人： Illumina, Inc.

发明人： BARNARD, Steven M. ,  BOWEN, M. Shane ,  ROGERT BACIGALUPO, Maria Candelaria ,  GEORGE, Wayne N. ,  BROWN, Andrew A. ,  TSAY, James

IPC分类号： C12Q1/6837

公开(公告)号：EP3038834B1

公开(公告)日：2018-12-12

申请号：EP14767207.5

申请日：2014-08-29

申请人： Illumina, Inc. ,  Illumina France S.A.R.L.

发明人： JAMSHIDI, Arash ,  LIN, Yan-You ,  ARAVANIS, Alex ,  DELATTRE, Cyril ,  RIVAL, Arnaud ,  FOLEY, Jennifer ,  SABOUNCHI, Poorya ,  KHURANA, Tarun ,  BABAZADEH, Majid ,  AMINI, Hamed ,  VENKATESAN, Bala Murali ,  BOWEN, M. Shane ,  BARNARD, Steven M. ,  ROGERT BACIGALUPO, Maria Candelaria ,  DEHLINGER, Dietrich

IPC分类号： B41J2/04

CPC分类号： B01L3/50273 ,  B01F13/0071 ,  B01F13/0076 ,  B01F13/0084 ,  B01L3/502792 ,  B01L2200/06 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0858 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2300/166 ,  B01L2400/0427 ,  B41J2/04 ,  G01N15/1463 ,  G01N15/1475 ,  G01N2015/1006

摘要： Provided herein is a droplet actuator including (a) first and second substrates separated by a droplet-operations gap, the first and second substrates including respective hydrophobic surfaces that face the droplet-operations gap; (b) a plurality of electrodes coupled to at least one of the first substrate and the second substrate, the electrodes arranged along the droplet-operations gap to control movement of a droplet along the hydrophobic surfaces within the droplet-operations gap; and (c) a hydrophilic or variegated-hydrophilic surface exposed to the droplet-operations gap, the hydrophilic or variegated-hydrophilic surface being positioned to contact the droplet when the droplet is at a select position within the droplet-operations gap.