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21.发明授权JOINT PRODUCT CONTAINING PHENTERMINE AND TOPIRAMATE AND PREPARATION METHOD THEREFOR 有权随着产品芬特明和托吡酯及其制造方法CONNECTION
公开(公告)号：EP2829266B1
公开(公告)日：2016-11-30
申请号：EP13763543.9
申请日：2013-03-20
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/16 , A61K9/52 , A61K31/35 , A61K31/357 , A61K9/50 , A61K9/48 , A61K31/137
CPC分类号： A61K31/357 , A61K9/4808 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K2300/00
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22.发明授权THIAZOLAMINE DERIVATIVE AND USE THEREOF AS ANTI-PICORNAVIRAL INFECTION MEDICAMENT 有权THIAZOLAMINDERIVAT及其作为药物的用途反对小核糖核酸病毒感染
公开(公告)号：EP2650292B1
公开(公告)日：2015-08-26
申请号：EP11847007.9
申请日：2011-12-06
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D417/04 , A61K31/496 , A61P31/14 , A61P31/16
CPC分类号： C07D417/04 , A61K31/496 , C07D277/42 , Y02A50/465
摘要： Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.
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23.发明授权ARYL PYRIMIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF 有权ARYLPYRIMIDINDERIVATE，方法和药物它们的应用
公开(公告)号：EP2184277B1
公开(公告)日：2015-07-01
申请号：EP08783534.4
申请日：2008-07-18
发明人： LI, Song , YANG, Yanbo , XIAO, Junhai , ZHONG, Wu , ZHENG, Zhibing , LI, Xingzhou , XIE, Yunde , WANG, Lili , LIU, Hongying
IPC分类号： C07D239/24 , C07D239/26 , A61K31/505 , A61P3/00 , A61P3/06 , A61P3/08 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/04 , A61P5/48
CPC分类号： C07D239/26
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24.发明公开DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS 有权VERWENDUNG ZUR HERSTELLUNG VON BETA-SEKRETASEHEMMERN中的替代品替代品
公开(公告)号：EP2116526A1
公开(公告)日：2009-11-11
申请号：EP07702276.2
申请日：2007-02-05
发明人： LI, Song , LIAO, Guochao , XIAO, Junhai , NIE, Aihua , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing
IPC分类号： C07C235/12 , C07D241/04 , A61K31/16 , A61K31/4965 , A61P25/28 , A61P25/00 , A61P43/00
CPC分类号： C07C235/16 , C07C235/12 , C07C237/42 , C07C2601/14 , C07D235/06 , C07D295/185
摘要： The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof:
in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of β-amyloid peptide.摘要翻译： 本发明涉及由式（I）表示的化合物或其异构体，前体药物，药学上可接受的盐，溶剂合物或水合物：其中式（I）的每个取代基如说明书中所定义。 本发明还涉及由式（I）表示的化合物的制备方法，包含由式（I）表示的化合物和式（I）表示的化合物用于治疗慢性神经变性疾病如阿尔茨海默病和其他疾病的药物组合物的制备方法 通过β-淀粉状蛋白肽的聚集或沉积诱导。
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公开(公告)号：EP3381910A1
公开(公告)日：2018-10-03
申请号：EP16867999.1
申请日：2016-11-24
发明人： LI, Song , XIAO, Junhai , XU, Libao , CAO, Ruiyuan , CAO, Fangyuan , WANG, Hongliang , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D277/52 , A61K31/426 , A61P31/12 , A61P31/16 , A61P11/04 , A61P1/16 , A61P31/18 , A61P31/14
CPC分类号： A61K31/426 , C07D277/52 , Y02A50/465
摘要： The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.
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公开(公告)号：EP3327010A1
公开(公告)日：2018-05-30
申请号：EP16817233.6
申请日：2016-06-28
发明人： LI, Song , XIAO, Junhai , LYU, Boqun , WANG, Hongqiang , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui
摘要： The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.
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27.发明授权
公开(公告)号：EP3006432B1
公开(公告)日：2017-11-15
申请号：EP14804849.9
申请日：2014-05-28
发明人： LI, Song , XIAO, Junhai , ZHANG, Xian , ZHONG, Wu , ZHENG, Zhibing , WANG, Lili , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D303/48 , C07D301/00 , C07D417/12 , C07D417/14 , A61K31/336 , A61K31/427 , A61K31/428 , A61P31/14 , A61P31/16
CPC分类号： C07D417/12 , C07D303/48 , C07D417/14
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28.发明公开N-SULFONYL HOMOSERINE LACTONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE 审中-公开N-SULFONYL-HOMOSERIN-LACTON-DERIVATE，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG
公开(公告)号：EP3150594A1
公开(公告)日：2017-04-05
申请号：EP15798935.1
申请日：2015-05-25
发明人： LI, Song , XIAO, Junhai , SUN, Qi , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui , CAO, Ruiyuan
IPC分类号： C07D405/00 , A61K31/34 , A61P31/00
CPC分类号： C07D409/12 , A61K31/34 , A61K31/365 , A61K31/381 , A61K31/4025 , A61K45/06 , C07D307/33 , C07D405/00 , C07D405/12 , C07D407/12 , C12Q1/025 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium.
摘要翻译： 本发明涉及式I的高丝氨酸内酯衍生物，其制备方法和用途。 该化合物具有细菌感染调节的作用，并且可用于预防和/或治疗由细菌感染引起的疾病。
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29.发明公开SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE 审中-公开替代乙酰胆碱酯酸酯，维他命ZUR HERSTELLUNG UND VERWENDUNG
公开(公告)号：EP3150576A1
公开(公告)日：2017-04-05
申请号：EP15800371.5
申请日：2015-05-20
发明人： LI, Song , XIAO, Junhai , WANG, Lili , LONG, Long , LI, Wei , LUO, Haoming , LI, Feifei , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui , CAO, Ruiyuan
IPC分类号： C07C251/86 , C07C249/16 , C07C253/30 , C07C255/58 , A61K31/277 , A61K31/165 , A61P7/06 , A61P7/08
CPC分类号： C07C251/86 , A61K31/165 , A61K31/277 , C07C249/16 , C07C253/30 , C07C255/58
摘要： The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.
摘要翻译： 本发明涉及药物化学品领域，涉及取代的乙酰肼衍生物，其制备方法和用途; 优选地涉及式I的化合物或其药学上可接受的盐。 本发明的化合物或其药学上可接受的盐可有效抑制脯氨酸羟化酶，稳定HIF-1，特别是HIF-1±，并且在制备用于治疗和/或预防和/或辅助治疗的药物中具有效力 贫血，急性缺血再灌注损伤。
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30.发明公开N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF 审中-公开N，N'-SUBSTITUIERTE PIPERIDINAMINVERBINDUNGEN UND HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON
公开(公告)号：EP3085701A1
公开(公告)日：2016-10-26
申请号：EP14872369.5
申请日：2014-12-19
发明人： ZHONG, Wu , LI, Song , ZENG, Yanqun , XIAO, Junhai , ZHOU, Xinbo , ZHENG, Zhibing , LI, Xingzhou , WANG, Xiaokui , WANG, Lili
IPC分类号： C07D417/06 , C07D401/04 , A61K31/506 , A61K31/454 , A61P35/00 , A61P25/28 , A61P37/06 , A61P31/00
CPC分类号： C07D417/06 , A61K31/454 , A61K31/506 , A61K45/06 , C07D401/04
摘要： The present invention relates to a compound of formula (I), a stereomeride, pharmaceutically acceptable salt, a solvate or an N-oxide thereof, a medicine composition comprising the compound, a method for preparing the compound, and a usage of the compound in treating diseases related to Hsp70. The diseases are preferably selected from tumors, neurodegenerative diseases, and allogeneic transplantation rejection and infection.
摘要翻译： 本发明涉及式（I）的化合物，立体异构体，其药学上可接受的盐，溶剂合物或N-氧化物，包含该化合物的药物组合物，该化合物的制备方法和该化合物的用途 治疗与Hsp70有关的疾病。 这些疾病优选选自肿瘤，神经变性疾病和同种异体移植排斥反应和感染。
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