公开(公告)号：EP1303487A1

公开(公告)日：2003-04-23

申请号：EP01959041.3

申请日：2001-07-19

申请人： Schering Corporation ,  CORVAS INTERNATIONAL, INC.

发明人： SAKESENA, Anil K. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  BOGEN, Stephane, L. ,  LOVEY, Raymond, G. ,  JAO, Edwin, E. ,  BENNETT, Frank ,  MC CORMICK, Jinping, L. ,  WANG, Haiyan ,  PIKE, Russell, E. ,  LIU, Yi-Tsung ,  CHAN, Tin-Yau ,  ZHU, Zhaoning ,  ARASAPPAN, Ashok ,  CHEN, Kevin, X. ,  VENKATRAMAN, Srikanth ,  PAREKH, Tejal, N. ,  PINTO, Patrick, A. ,  SANTHANAM, Bama ,  NJOROGE, F., George ,  GANGULY, Ashit K. ,  VACCARO, Henry A. ,  KEMP, Scott Jeffrey ,  LEVY, Odile Esther ,  LIM-WILBY, Marguerita ,  TAMURA, Susan Y.

IPC分类号： C07D209/02 ,  C07D211/04 ,  C07D233/56 ,  C07D317/10 ,  C07D319/04 ,  C07D339/02 ,  C07D339/08 ,  C07C229/00 ,  C07C233/05 ,  C07C271/08 ,  C07C271/32 ,  A61K31/16 ,  A61K31/27 ,  A61K31/195 ,  A61K31/357 ,  A61K31/385 ,  A61K31/403 ,  A61K31/445 ,  A61K31/4164

CPC分类号： C07K7/06 ,  A61K31/16 ,  A61K31/195 ,  A61K31/27 ,  A61K31/357 ,  A61K31/385 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/445 ,  A61K38/05 ,  C07C205/51 ,  C07K5/101 ,  C07K7/02 ,  A61K2300/00

摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP1274724A2

公开(公告)日：2003-01-15

申请号：EP01927142.8

申请日：2001-04-17

申请人： SCHERING CORPORATION

发明人： VENKATRAMAN, Srikanth ,  CHEN, Kevin, X. ,  ARASAPPAN, Ashok ,  NJOROGE, F., George ,  GIRIJAVALLABHAN, Viyyoor, M. ,  CHAN, Tin-Yau ,  MCKITTRICK, Brian, A. ,  PRONGAY, Andrew, J. ,  MADISON, Vincent, S.

IPC分类号： C07K7/06 ,  C07K14/18 ,  C07K5/062 ,  C07K5/065 ,  C07K5/107 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08 ,  A61P31/14

CPC分类号： C07K5/0202 ,  A61K38/00 ,  C07K7/02

摘要： The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP2408761A1

公开(公告)日：2012-01-25

申请号：EP08795629.8

申请日：2008-08-27

申请人： Schering Corporation

发明人： ANILKUMAR, Gopinadhan, N. ,  BENNETT, Frank ,  CHAN, Tin-Yau ,  CHEN, Kevin, X. ,  SANNIGRAHI, Mousumi ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  ZENG, Qingbei ,  DUCA, Jose, S. ,  LESBURG, Charles, A. ,  KOZLOWSKI, Joseph, A. ,  NJOROGE, F., George ,  ROSENBLUM, Stuart, B. ,  SHIH, Neng-Yang

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07D403/04 ,  C07D401/04

摘要： The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

公开(公告)号：EP1534712B1

公开(公告)日：2007-05-16

申请号：EP03796321.2

申请日：2003-09-03

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  ALVAREZ, Carmen, S. ,  CHAN, Tin-Yau ,  KNUTSON, Chad ,  MADISON, Vincent ,  FISCHMANN, Thierry, O. ,  DILLARD, Lawrence, W. ,  TRAN, Vinh, D. ,  HE, Zhen Min ,  JAMES, Ray, Anthony ,  PARK, Haengsoon

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP1720882A2

公开(公告)日：2006-11-15

申请号：EP05722809.0

申请日：2005-02-08

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： GUZI, Timothy J. ,  PARUCH, Kamil ,  DWYER, Michael P. ,  DOLL, Ronald J. ,  GIRIJAVALLABHAN, Viyyoor Moopil ,  MALLAMS, Alan ,  ALVAREZ, Carmen S. ,  KEERTIKAR, Kartik M. ,  RIVERA, Jocelyn ,  CHAN, Tin-Yau ,  MADISON, Vincent ,  FISCHMANN, Thierry O. ,  DILLARD, Lawrence W. ,  TRAN, Vinh D. ,  HE, Zhen Min ,  JAMES, Ray Anthony ,  PARK, Haengsoon ,  PARADKAR, Vidyadhar M. ,  HOBBS, Douglas Walsh

IPC分类号： C07D487/04 ,  A61K31/495 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/495

摘要： In its many embodiments, the present invention provides pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP1537116A1

公开(公告)日：2005-06-08

申请号：EP03794592.0

申请日：2003-09-03

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  MALLAMS, Alan ,  ALVAREZ, Carmen, S. ,  KEERTIKAR, Kartik, M. ,  RIVERA, Jocelyn ,  CHAN, Tin-Yau ,  MADISON, Vincent ,  FISCHMANN, Thierry, O. ,  DILLARD, Lawrence, W. ,  TRAN, Vinh, D. ,  HE, Zhen Min ,  JAMES, Ray, Anthony ,  PARK, Haengsoon ,  PARADKAR, Vidyadhar, M. ,  HOBBS, Douglas, Walsh

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP1370528B1

公开(公告)日：2005-06-08

申请号：EP02709850.8

申请日：2002-03-20

申请人： SCHERING CORPORATION

发明人： CLADER, John, W. ,  JOSIEN, Hubert, B. ,  PALANI, Anandan ,  CHAN, Tin-Yau

IPC分类号： C07D211/26 ,  A61K31/445 ,  C07D241/04 ,  A61P3/04

CPC分类号： C07D295/215 ,  A61K45/06 ,  C07D211/26 ,  C07D211/28 ,  C07D211/34 ,  C07D211/58 ,  C07D211/96 ,  C07D211/98 ,  C07D295/155 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14

摘要： The present invention discloses compounds of the formula (I) which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.