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    VETERINARY COMPOSITION AND METHODS FOR NON-SURGICAL NEUTERING AND CASTRATION
    21.
    发明公开
    VETERINARY COMPOSITION AND METHODS FOR NON-SURGICAL NEUTERING AND CASTRATION 审中-公开
    天竺葵ZUSAMMENSETZUNG UND VERFAHRENFÜRNICHTOPERATIVE KASTRATION

    公开(公告)号：EP2900275A2

    公开(公告)日：2015-08-05

    申请号：EP13842169.8

    申请日：2013-09-27

    申请人： The Trustees Of The University Of Pennsylvania

    发明人： WILSON, James, M. ,  HINDERER, Christian ,  WILSON, John, F.

    IPC分类号： A61K48/00 ,  A61K38/09 ,  A61P5/02

    CPC分类号： A01K21/00 ,  A01K29/00 ,  A01K67/027 ,  A01K2207/05 ,  A01K2227/108 ,  A01K2267/02 ,  A61K9/19 ,  A61K31/713 ,  C07K16/26 ,  C07K16/2869 ,  C07K2317/24 ,  C12N2750/14143

    摘要： A method for non-surgical neutering or castration of a non-human mammal for AAV-mediated delivery of an anti-GnRH polypeptide to a non-human animal is described. More particularly, the animal is administered an adeno-associated virus (AAV) vector having an AAV capsid having packaged therein nucleic acid sequences comprising an AAV 5′ inverted terminal repeat (ITR), a sequence encoding a polypeptide which specifically binds gonadotropin releasing hormone (GnRH) under control of regulatory sequences which direct expression of the polypeptide, and an AAV 3′ ITR. A composition comprising the AAV-anti-GnRH may also be used for inhibiting tumor growth in a mammal with a cancer responsive to gonadal steroid hormones.

    摘要翻译： 描述了用于非人类哺乳动物非手术中断或去势的用于AAV介导的将抗GnRH多肽递送至非人动物的方法。 更具体地，给动物施用具有包装在其中的AAV衣壳的腺相关病毒（AAV）载体，所述核酸序列包含AAV5'反向末端重复（ITR），编码特异性结合促性腺激素释放激素的多肽 GnRH），其指导多肽的表达调控序列，以及AAV 3'ITR。 包含AAV-抗GnRH的组合物也可用于抑制具有对性腺类固醇激素的响应的癌症的哺乳动物的肿瘤生长。

    REGIMENS AND COMPOSITIONS FOR AAV-MEDIATED PASSIVE IMMUNIZATION OF AIRBORNE PATHOGENS
    22.
    发明公开
    REGIMENS AND COMPOSITIONS FOR AAV-MEDIATED PASSIVE IMMUNIZATION OF AIRBORNE PATHOGENS 审中-公开
    DOSIERPLÄNE并为LUFTBÜRTIGEN病原体AAV介导的被动免疫组合物

    公开(公告)号：EP2699688A1

    公开(公告)日：2014-02-26

    申请号：EP12719540.2

    申请日：2012-04-20

    申请人： The Trustees Of The University Of Pennsylvania

    发明人： WILSON, James, M. ,  LIMBERIS, Maria, P.

    IPC分类号： C12N15/861 ,  A61K39/40 ,  A61K39/42

    CPC分类号： A61K31/713 ,  A61K39/07 ,  A61K2039/505 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/543 ,  C07K16/1018 ,  C12N2750/14132

    摘要： A prophylactic regimen for passively preventing infection with a pathogen which has a typical route of infection through the nasopharynx region of a subject, e.g., an airborne virus typically transmitted through coughing or sneezing. The method involves specifically targeting a subject's nasopharynx with a viral vector comprising an AAV capsid and carrying a nucleic acid sequence encoding an anti-viral neutralizing antibody construct operably linked to expression control sequences, in order to provide for high levels of expression of the anti-viral neutralizing antibody construct in the nasal airway cells. Optionally, the neutralizing antibody construct is expressed under a promoter which is regulated or induced by a small molecule which is delivered separately from the viral vector. In one embodiment, the method permits transfection of a subject's nasopharynx even where the subject has circulating neutralizing antibodies against the AAV capsid.

    摘要翻译： 的预防方案用于被动预防感染与具有通过对象的鼻咽区域中，E. G.感染的典型路线，通过咳嗽或打喷嚏空降病毒的反式通常mitted病原体。 该方法涉及特异性靶向受试者用病毒载体，其包含AAV衣壳和携带的核酸序列编码抗病毒的中和抗体的构建体可操作地连接至表达控制序列鼻咽部，以提供高水平的抗的表达的 病毒中和抗体在鼻腔气道细胞构建体。 任选地，中和抗体构建体的启动子下过表达所有这些被调节或通过小分子诱导的所有这是从病毒载体分开传送。 在一个中，实施例方法允许受试者的鼻咽即使在受试者的循环中和抗体针对AAV衣壳的转染。

    METHOD FOR TOLERIZING A MAMMALIAN PATIENT TO ADMINISTRATION OF GENE THERAPY VIRUS VECTORS
    27.
    发明授权
    METHOD FOR TOLERIZING A MAMMALIAN PATIENT TO ADMINISTRATION OF GENE THERAPY VIRUS VECTORS 失效
    METHOD FOR PRODUCING的哺乳动物PATIENTES公差AGAINST DELIVERY基因治疗的病毒载体

    公开(公告)号：EP0930896B1

    公开(公告)日：2003-01-02

    申请号：EP97940869.7

    申请日：1997-09-04

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

    发明人： WILSON, James, M. ,  CHEN, Youhai

    IPC分类号： A61K39/12 ,  A61K48/00 ,  A61P37/04

    CPC分类号： A61K48/00

    摘要： A method for tolerizing a mammalian subject to administration of a live virus carrying a gene for delivery to a cell of the subject is disclosed. The method entails administering to the subject a suitable amount of an inactivated virus prior to administration of the live virus. The prior administration of the inactivated virus suppresses anti-virus cytotoxic T cells, permitting longer transgene persistence once the live virus is administered, and permitting effective readministration of live virus.

    摘要翻译： 一种耐受哺乳动物受活病毒携带传递的基因的受试者细胞的给药方法是游离缺失盘。 该方法需要向受试者施用灭活病毒的合适量的活病毒的给药之前。 灭活病毒的现有给药禁止抗病毒细胞毒性T细胞，从而允许更长的持久性的转基因一旦活病毒施用，并允许活病毒的再次给药有效。