公开(公告)号：EP1385571B1

公开(公告)日：2008-07-30

申请号：EP02731254.5

申请日：2002-04-04

申请人： Alza Corporation

发明人： CORMIER, Michel, J., N. ,  YOUNG, Wendy, A.

IPC分类号： A61N1/30

CPC分类号： A61N1/30

公开(公告)号：EP1933811A2

公开(公告)日：2008-06-25

申请号：EP06815377.4

申请日：2006-09-25

申请人： Alza Corporation

发明人： WONG, Patrick, S.L. ,  LAM, Andrew, C.

IPC分类号： A61K9/00

CPC分类号： A61K9/146 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/2072 ,  A61K9/2077 ,  A61K9/2095 ,  B82Y5/00

摘要： Disclosed are controlled release dosage forms and related methods wherein controlled release of self-dispersing nanoparticle active agent formulations is provided by formulating porous particles into which have been sorbed a self-dispersing nanoparticle active agent formulation.

公开(公告)号：EP1926489A2

公开(公告)日：2008-06-04

申请号：EP06836116.1

申请日：2006-09-12

申请人： Alza Corporation

发明人： HUSSEIN, Mohamad, A.

IPC分类号： A61K31/454 ,  A61K31/475 ,  A61K31/573 ,  A61K31/704 ,  A61K9/127

CPC分类号： A61K9/1271 ,  A61K9/1273 ,  A61K31/454 ,  A61K31/475 ,  A61K31/573 ,  A61K31/704 ,  A61K45/06 ,  C07K16/2803

摘要： A method for treating multiple myeloma in newly diagnosed or previously treated patients is described. The method comprises administering a composition consisting of a combination of chemotherapeutic agents of an anthracycline antibiothic, preferably entrapped in a liposome, dexamethasone, and thalidomide, and, optionally, a reduced dose of vincristine.

公开(公告)号：EP1895995A2

公开(公告)日：2008-03-12

申请号：EP06759665.0

申请日：2006-05-12

申请人： Alza Corporation

发明人： JANSEN, Rolf, R. ,  CORONADO, Dina, J.

IPC分类号： A61K9/70

CPC分类号： A61J3/00 ,  A61F13/0203 ,  A61F2013/0296 ,  A61K9/7061 ,  A61K31/55 ,  Y10T156/1082

摘要： A multilayered drag delivery system with a barrier suitable for delivery of galantamine through an individual's body surface. By placing a barrier between two adjacent layers, unintended galantamine flow due to migration of a drag matrix between the adjacent matrix layers in the system to a patient is avoided.

公开(公告)号：EP1895994A2

公开(公告)日：2008-03-12

申请号：EP06759664.3

申请日：2006-05-12

申请人： ALZA CORPORATION

发明人： JANSEN, Rolf, R. ,  CORONADO, Dina, J.

IPC分类号： A61K9/70

CPC分类号： A61J3/00 ,  A61F13/0203 ,  A61F2013/0296 ,  A61K9/7061 ,  A61K31/55 ,  Y10T156/1082

摘要： A multilayered drug delivery system with a barrier suitable for delivery of drug through an individual's body surface. By placing a barrier between two adjacent layers, unintended drug flow due to migration of a drug matrix between the adjacent matrix layers in the system to a patient is avoided.

公开(公告)号：EP1885405A1

公开(公告)日：2008-02-13

申请号：EP06772047.4

申请日：2006-06-01

申请人： Alza Corporation, Inc.

发明人： AMERI, Mahmoud ,  MAA, Yuh-Fun

IPC分类号： A61L2/00 ,  A61L2/08 ,  A61K9/00 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61K41/0019 ,  A61L2/081 ,  A61L2/087 ,  A61L2/206 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A method and system for providing a terminally sterilized transdermal device adapted to delivery a parathyroid hormone-based agent. A microprojection member that includes a plurality of stratum corneum-piercing microprojections is coated with PTH-based agent formulation an exposed to sufficient radiation to sterilize the microprojection member while retaining sufficient activity of the PTH-based agent. Preferably, the microprojection member is sealed in packing with an inert atmosphere and reduced moisture. The sterilizing radiation can be gamma radiation or e-beam, preferably delivered in a dose in the range of approximately 5 - 50 kGy. Also preferably, the irradiation is performed at -78.5-25°C. In preferred embodiments, the radiation is delivered at a rate greater than 3.0 kGy/hr.

摘要翻译： 一种用于提供适于递送基于甲状旁腺激素的药剂的末端无菌透皮装置的方法和系统。 包含多个刺穿角质层的微突出物的微突出物构件涂覆有基于PTH的药物制剂，暴露于足够的辐射下以杀菌微突出物构件，同时保持基于PTH的药物的足够活性。 优选地，将微突起构件用惰性气氛和减少的湿气密封包装。 灭菌辐射可以是γ辐射或电子束，优选以约5-50kGy的剂量递送。 还优选地，照射在-78.5-25℃下进行。 在优选实施例中，辐射以大于3.0kGy / hr的速率传递。

公开(公告)号：EP1874324A1

公开(公告)日：2008-01-09

申请号：EP06751290.5

申请日：2006-04-20

申请人： Alza Corporation

发明人： ALVAREZ, Ronald, D. ,  STRAUGHN, Michael, J., Jr.

IPC分类号： A61K31/704 ,  A61K9/127 ,  A61P35/00

CPC分类号： A61K31/704 ,  A61K9/0019 ,  A61K9/1271

摘要： A method for treating advanced epithelial ovarian cancer patients who attain a clinically-defined complete response after initial platinum/paclitaxel-based chemotherapy is described. The method involves administering a chemotherapeutic agent, such as doxorubicin, entrapped in liposomes.

公开(公告)号：EP1853288A2

公开(公告)日：2007-11-14

申请号：EP06719803.6

申请日：2006-01-27

申请人： Alza Corporation, Inc.

发明人： BENTZ, Hanne ,  HILL, Beth ,  LUCAS, Catherine ,  FREY, William, H.

IPC分类号： A61K38/00

CPC分类号： A61K38/34 ,  A61K9/0043 ,  A61K47/6811 ,  A61K51/08 ,  A61K51/086 ,  C07K2319/30

摘要： A method for delivering a polypeptide to the central nervous system of a mammal is provided. The method involves attaching the polypeptide to an antibody or an antibody fragment and administering the fusion polypeptide intranasally, for delivery to the central nervous system. Methods of treatment are also provided, where a therapeutically effective amount of the composition is delivered to the nasal cavity of a mammal.

公开(公告)号：EP1827399A1

公开(公告)日：2007-09-05

申请号：EP05849923.7

申请日：2005-12-14

申请人： Alza Corporation

发明人： MITTUR, Aravindkumar

IPC分类号： A61K9/70 ,  A61K9/00

CPC分类号： A61K9/7084 ,  A61F7/007 ,  A61F2007/0001 ,  A61F2007/0075 ,  A61K9/0004 ,  A61M37/00

摘要： A trans-body-surface drug delivery device for the administration of at least one drug to an individual at a therapeutically effective rate. The device including reservoir having at least one drug and a thermoeffector having a first surface that is controllable to at least one of heating and cooling the reservoir to affect passage rate of the drug through the body surface.

公开(公告)号：EP1809254A2

公开(公告)日：2007-07-25

申请号：EP05821048.5

申请日：2005-10-28

申请人： ALZA CORPORATION

发明人： WONG, Harry ,  ZHANG, Yuanpeng ,  HUANG, Anthony, Hei-Leung

IPC分类号： A61K9/19 ,  A61K9/127 ,  A61K31/00

CPC分类号： A61K31/337 ,  A61K9/127 ,  A61K9/19 ,  A61K31/00 ,  A61K31/4196 ,  A61K31/4706 ,  A61K31/55 ,  A61K31/573 ,  A61K31/7012 ,  A61K31/7048 ,  A61K31/7072 ,  A61K38/13

摘要： Formulations and methods for preparing a lyophilized composition comprising liposomes comprised of an unsaturated lipid and a hydrophobic drug associated with the liposome, and a cryoprotectant in a solution at a selected concentration. The phase transition temperature of the lipid is greater than the freezing point of the solution at the selected concentration. Preferably the lipid is palmitoyl-oleoylphosphatidylcholine and the cryoprotectant is sucrose.