公开(公告)号：EP2424524A1

公开(公告)日：2012-03-07

申请号：EP10719367.4

申请日：2010-04-30

申请人： University Court of The University of Dundee

发明人： EVERETT, Steven, Albert ,  ULHAQ, Saraj

IPC分类号： A61K31/343 ,  A61K31/352 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/664 ,  C07D307/80 ,  C07D311/16 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  A61P35/00 ,  A61P9/10

CPC分类号： A61K47/545 ,  A61K31/343 ,  A61K31/352 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/513 ,  A61K31/52 ,  A61K31/664 ,  A61K31/665 ,  C07D307/80 ,  C07D311/16 ,  C07D311/18 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/22

摘要： The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1 B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.

公开(公告)号：EP2336139A3

公开(公告)日：2012-01-04

申请号：EP10178414.8

申请日：2005-10-25

申请人： Dekk-Tec, Inc.

发明人： Morgan, Lee

IPC分类号： C07F9/22 ,  A61K31/66 ,  A61K31/675

CPC分类号： C07F9/222 ,  A61K31/664 ,  A61K45/06 ,  C07C229/26

摘要： The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula I: (I) wherein A + represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

公开(公告)号：EP2368551A3

公开(公告)日：2011-12-21

申请号：EP11165825.8

申请日：2007-12-27

申请人： Infinity Discovery, Inc. ,  THE JOHNS-HOPKINS UNIVERSITY

发明人： Matsui, William ,  Tremblay, Martin R. ,  Castro, Alfredo C. ,  Grogan, Michael J. ,  McGovern, Karen J.

IPC分类号： A61K31/4355 ,  A61K31/58 ,  A61P35/00 ,  A61P35/02 ,  C07D491/04 ,  C07D491/10 ,  C07J69/00

CPC分类号： C07D491/048 ,  A61K9/0014 ,  A61K31/17 ,  A61K31/196 ,  A61K31/198 ,  A61K31/4355 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/664 ,  A61K31/69 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  A61N5/10 ,  C07D307/94 ,  C07D471/04 ,  C07D471/10 ,  C07D491/04 ,  C07D491/10 ,  C07D491/107 ,  C07J69/00

摘要： The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:

公开(公告)号：EP2324031A1

公开(公告)日：2011-05-25

申请号：EP09781165.7

申请日：2009-07-28

申请人： Pierre Fabre Medicament

发明人： MARION, Frédéric ,  ANNEREAU, Jean-Philippe ,  FAHY, Jacques

IPC分类号： C07D491/04 ,  A61K31/473 ,  A61K31/4525

CPC分类号： C07D491/056 ,  A61K31/4741 ,  A61K31/513 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/664 ,  A61K31/704 ,  A61K31/7056 ,  A61K31/7076 ,  A61K33/24 ,  A61K38/12 ,  A61K38/50 ,  C07D491/04

摘要： The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin of the following general formula (I) as well as their pharmaceutically acceptable salts. The present invention also concerns the use of these compounds in cancer therapy as well as a method for their preparation.

公开(公告)号：EP2193204A2

公开(公告)日：2010-06-09

申请号：EP08839001.8

申请日：2008-09-25

申请人： Universite de Bretagne Occidentale ,  Centre National de la Recherche Scientifique

发明人： CLEMENT, Jean-Claude ,  PICHON, Harivony ,  MIDOUX, Patrick ,  YAOUANC, Jean-Jacques ,  MEVEL, Mathieu

IPC分类号： C12N15/88 ,  A61K48/00 ,  A61K47/24 ,  A61K31/664 ,  A61K45/06 ,  C07F9/22 ,  A61K31/7084

CPC分类号： A61K31/664 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2267/03 ,  A61K9/1272 ,  A61K31/7084 ,  A61K48/00 ,  C07F9/2458 ,  C07F9/65061 ,  C07F9/65067 ,  C12N15/88

摘要： The invention relates to novel co-lipids that can be used in combination with lipophilic compounds used as nucleic acid vectors, for making a nucleic-acid vector composition. The invention also relates to nucleic-acid vector compositions containing a combination of (i) a nucleic-acid cationic lipohilic vector and (ii) a co-lipid. In some embodiments, the nucleic-acid vector compositions are in the form of unilamellar or multilamellar vesicles. The invention also relates to a method for the in vitro or in vivo insertion of a nucleic acid of interest into host cells, that comprises the step of contacting said host cells with a nucleic-acid vector composition as described above.

公开(公告)号：EP1827101A4

公开(公告)日：2009-04-29

申请号：EP05851858

申请日：2005-11-17

申请人： EXPRESSION GENETICS INC

发明人： FEWELL JASON G ,  MATAR MAJED ,  RICE JENNIFER ,  LEWIS DANNY H ,  ANWER KHURSHEED

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K48/00 ,  C12N15/87

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/17 ,  A61K31/28 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/664 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K33/24 ,  A61K38/208 ,  A61K39/39558 ,  A61K47/10 ,  A61K47/6951 ,  A61K48/0041 ,  A61K48/005 ,  B82Y5/00 ,  C12N15/87 ,  A61K2300/00

公开(公告)号：EP0942915B1

公开(公告)日：2008-06-25

申请号：EP97913320.4

申请日：1997-11-21

申请人： ITC Research Limited

发明人： DOGADINA, Albina Vladimirovna ,  GOUREVITCH, Igor Evgenyevich ,  IONINE, Boris Iosifovich

IPC分类号： C07F9/113 ,  A61K31/66 ,  A01N1/02 ,  G01N33/50 ,  C12P19/00 ,  C07F9/24

CPC分类号： A61K31/661 ,  A61K31/664 ,  C07F9/113 ,  C07F9/2412 ,  C07F9/2462 ,  C12P9/00

摘要： A compound of formula (1), particularly where X = O, Y = NR1R2, wherein R1 = R2 = H and Z1 = Z2 = OH, can protect and/or aid the recovery of functionally impaired tissue whose viability is threatened by hypoxia. Typically, the compounds can be used to aid recovery of function of ischaemic tissue during and after open heart surgery. In said formula, X = O or NH, Y = OH, OR?1, NR1R2¿, wherein R?1 and R2¿ are independently H, alkyl, alkenyl (except where applied to OR1), cycloalkyl, aryl, or aralkyl.

公开(公告)号：EP1805192A2

公开(公告)日：2007-07-11

申请号：EP05821125.1

申请日：2005-10-25

申请人： Dekk-Tec, Inc.

发明人： Morgan, Lee.

IPC分类号： C07F9/22

CPC分类号： C07F9/222 ,  A61K31/664 ,  A61K45/06 ,  C07C229/26

摘要： The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula I: (I) wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

公开(公告)号：EP1605952B1

公开(公告)日：2007-05-02

申请号：EP03816433.1

申请日：2003-11-20

申请人： Resprotect GmbH

发明人： FAHRIG, Rudolf ,  HEINRICH, Jörg-Christian ,  KRUPITZA, Georg

IPC分类号： A61K31/7072 ,  A61K31/664 ,  A61P35/00

CPC分类号： A61K31/664 ,  A61K31/7072

摘要： The invention relates to the use of at least one overexpression inhibitor of DNA repair genes and oncogenes for producing a medicament used for reinforcing the apoptotic effect of cytostatic drugs following chemotherapy.

公开(公告)号：EP0946183B1

公开(公告)日：2007-05-02

申请号：EP97946363.5

申请日：1997-10-29

申请人： Merck & Co., Inc.

发明人： LYNCH, Joseph, J., Jr. ,  SALATA, Joseph, J. ,  SWANSON, Richard, J. ,  FERMINI, Bernard

IPC分类号： A61K31/66 ,  A61K31/50 ,  A61P9/06

CPC分类号： A61K31/664 ,  A61K31/00 ,  A61K31/50 ,  A61K31/66 ,  Y10S514/821

摘要： A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium.