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    COMPOSITIONS FOR DYSPHAGIA ASSESSMENT
    21.
    发明公开
    COMPOSITIONS FOR DYSPHAGIA ASSESSMENT 审中-公开
    ZUSAMMENSETZUNGEN ZUR BEURTEILUNG VON DYSPHAGIE

    公开(公告)号：EP2825064A1

    公开(公告)日：2015-01-21

    申请号：EP13708838.1

    申请日：2013-03-13

    申请人： Fresenius Kabi Deutschland GmbH

    发明人： GALLEGOS-MONTES, Chrispulo ,  BRITO-DE LA FUENTE, Edmundo ,  MAINOU-SIERRA, José M. ,  QUINCHIA-BUSTAMANTE, Lida-Andrea ,  JOZAMI, Mirta Viviana ,  VALENCIA BARRAGÁN, Conceptión ,  FRANCO-GÓMEZ, Josè Maria

    IPC分类号： A23L1/30 ,  A61K49/04 ,  A61K49/18

    CPC分类号： A61K49/0404 ,  A23L29/37 ,  A23L33/10 ,  A23V2002/00 ,  A61K49/0495 ,  A61K49/1863

    摘要： Dysphagia, or abnormal swallowing of foods and/ or liquids, affects people of all ages from the newborn to the elderly. Management of dysphagia is commonly done by the prescription of texture-controlled diets. Ideally, the most appropriate modification of food consistencies should follow from a clear assessment of the swallowing problem. Rheology and swallowing are connected at the diagnosis level. The "gold standard" technique is a videofluoroscopic swallowing study (VFSS). The swallowing process can be visualized using videoradiography by employing either ready-to-use commercial contrast medium or by mixing food with barium sulphate (BaSO
    4 ), making it radiopaque. Unfortunately, there is no standardization to perform VFSS. This lack of standardization leads to variability of results as well as their interpretation. In practice, lack of standardization often requires that individual speech pathologist, dieticians and dysphagia food manufacturers determine their own dietary consistencies. Another possibility is the use of encapsulated MRI superparamagnetic contrast agents for oral administration. The main goal of this invention has been to develop new and improved formulations of carriers/vehicles for radio-opaque (barium sulphate) or magnetic contrast agents (superparamagnetic iron oxide) that can be used as ready-to-use/ powder commercial formulations as contrast media for imaging diagnosis (VFSS or MRI) of dysphagia.

    摘要翻译： 吞咽困难或食物和/或液体异常吞咽会影响新生儿到老年人各个年龄段的人群。 吞咽困难的管理通常由配方控制饮食。 理想情况下，对食物一致性进行最合适的修改应遵循对吞咽问题的明确评估。 流感和吞咽在诊断水平相连。 “黄金标准”技术是视频荧光吞咽研究（VFSS）。 吞咽过程可以通过使用即用型商业造影剂或通过将食物与硫酸钡（BaSO 4）混合使用，使其成为不透射线的视像摄影。 不幸的是，没有标准化来执行VFSS。 这种缺乏标准化导致结果的变化以及它们的解释。 实际上，缺乏标准化往往要求个别言语病理学家，营养师和吞咽困难的食品制造商决定自己的膳食一致性。 另一种可能性是使用封装的MRI超顺磁性造影剂进行口服给药。 本发明的主要目标是开发用于不透射线（硫酸钡）或磁性造影剂（超顺磁氧化铁）的载体/载体的新的和改进的制剂，其可以用作即用型/粉末商业制剂作为 造影剂用于影像诊断（VFSS或MRI）的吞咽困难。

    PROCESS FOR PREPARING DISPERSIBLE SULFATE, PREFERABLY BARIUM SULFATE NANOPARTICLES
    26.
    发明公开
    PROCESS FOR PREPARING DISPERSIBLE SULFATE, PREFERABLY BARIUM SULFATE NANOPARTICLES 有权
    用于生产分散硫酸，最好BARIUMSULFATNANOTEILCHEN

    公开(公告)号：EP1753827A1

    公开(公告)日：2007-02-21

    申请号：EP04730978.6

    申请日：2004-05-04

    申请人： Centrum für Angewandte Nanotechnologie (CAN) GmbH

    发明人： BERKEI, Michael ,  PFUNDT, Heiner

    IPC分类号： C09C1/02 ,  C01F11/46 ,  C01B17/96

    CPC分类号： C09C1/027 ,  A61K49/0404 ,  A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01P2002/52 ,  C01P2004/64 ,  Y10S977/773 ,  Y10S977/775

    摘要： The present invention relates to a process for the manufacture of optionally doped nanoparticulate metal sulfate nanoparticles wherein the metal is selected from polyvalent metals or monovalent transition metals, said process comprising the step of heating a reaction mixture comprising a) a polar organic solvent comprising at least two hydroxy groups or a polar organic solvent comprising at least one sulfoxide group, b) a source of a polyvalent metal or monovalent transition metal, a sulfate source, and optionally a dopant metal source, and c) a base selected from i) bases having an aromatic N-containing heterocycle with the exception of imidazole ii) bases having an aliphatic N-containing heterocycle, iii) aliphatic hydroxy-substituted amines iv) aliphatic polyamines v) aromatic amines vi) ammonia and ammonia-releasing compounds vii)metal hydroxides, and metal sulfates obtainable by this method. The resulting sulfate nanoparticle show a high degree of whiteness and an excellent dispersibility in water and according to preferred embodiments also in methanol.

    PH TRIGGERED TARGETED CONTROLLED RELEASE SYSTEMS
    27.
    发明公开
    PH TRIGGERED TARGETED CONTROLLED RELEASE SYSTEMS 审中-公开
    PH引发有针对性的控制下交付系统

    公开(公告)号：EP1569619A1

    公开(公告)日：2005-09-07

    申请号：EP03812765.0

    申请日：2003-08-21

    申请人： Salvona LLC

    发明人： SHEFER, Adi ,  SHEFER, Samuel, David

    IPC分类号： A61K9/14

    CPC分类号： A61K9/5138 ,  A61K9/1635 ,  A61K9/2077 ,  A61K9/5084 ,  A61K49/0404 ,  A61K49/0485 ,  B82Y5/00

    摘要： The present invention relates to a novel pH triggered, targeted controlled release system. The controlled delivery system of the present invention is substantially a free-flowing powder formed of solid hydrophobic nano-spheres comprising pharmaceutical active ingredients that are encapsulated in a pH sensitive micro-spheres. The invention also relates to the processes for preparing the compositions and processes for using same. The controlled release system can be used to target and control the release of pharmaceutical active ingredients onto certain regions of the gastrointestinal tract including the stomach and the small intestine. The invention further pertains to pharmaceutical products comprising the controlled release system of the present invention.

    ORALLY INGESTIBLE BAKED RADIOPAQUE PRODUCT FOR TESTING FOR DYSPHAGIA
    30.
    发明公开
    ORALLY INGESTIBLE BAKED RADIOPAQUE PRODUCT FOR TESTING FOR DYSPHAGIA 审中-公开
    BAKED不透辐射的产品，用于口服采取测试吞咽困难

    公开(公告)号：EP1331951A2

    公开(公告)日：2003-08-06

    申请号：EP01994517.9

    申请日：2001-11-07

    申请人： Wanda's Barium Cookie, L.L.C.

    发明人： KIISKILA, Wanda

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0409 ,  A61K49/0404

    摘要： An orally ingestible baked radiopaque product comprising (a) fat, (b) sweetener, (c) moisturizing agent, (d) x-ray contrast agent, (e) flour and (f) optionally flavoring agent useful for evaluating swallowing food having a dry food texture. The x-ray contrast agent is interspersed throughout the product by mixing it into the product prior to baking it. The product is used in the detection of dysphagia. A method and dough useful for preparing the product.