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    Drug-Carrying Contact Lens And Method For Fabricating The Same
    21.
    发明公开
    Drug-Carrying Contact Lens And Method For Fabricating The Same 有权
    Medikamententragende Kontaktlinse

    公开(公告)号：EP2543358A1

    公开(公告)日：2013-01-09

    申请号：EP12175463.4

    申请日：2012-07-06

    申请人： National Chiao Tung University

    发明人： Liu, Dean-Mo ,  Liu, Pei-Ling

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K9/51

    CPC分类号： A61K9/5161 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/1273 ,  A61K9/5115

    摘要： The present invention discloses a drug-carrying contact lens and a method for fabricating the same. The drug-carrying contact lens comprises a contact lens containing at least one amphiphatic hybrid nanocarrier carrying drug molecules. According to the heat or light sensitivity of the drug molecule, the present invention respectively fabricates an encapsulation-type drug-carrying contact lens and a drug-soaking type drug-carrying contact lens. The present invention uses a highly-biocompatible amphiphatic hybrid nanocarriers having superior drug encapsulation capability to wrap the drug molecules. Thereby, the drug molecules are uniformly distributed in the contact lens and can be gradually and locally released to the eye of the user wearing the contact lens. Therefore, the present invention can prevent or cure ocular diseases with the loss and side effects of the drug being reduced.

    摘要翻译： 本发明公开了一种携带药物的隐形眼镜及其制造方法。 载药隐形眼镜包含含有携带药物分子的至少一个两亲性杂合纳米载体的隐形眼镜。 根据药物分子的热或光敏感性，本发明分别制造包封型药物接触镜片和药物浸泡型药物接触镜片。 本发明使用具有优异的药物包封能力的高度生物相容的两亲性杂合纳米载体来包裹药物分子。 因此，药物分子均匀分布在隐形眼镜中，并且可以逐渐地和局部地释放到穿着隐形眼镜的使用者的眼睛上。 因此，本发明可以防止或治疗眼药水的损失和副作用降低的疾病。

    POLYMERSOME AND PROCESS FOR PRODUCING SAME
    22.
    发明公开
    POLYMERSOME AND PROCESS FOR PRODUCING SAME 有权
    POLYMERSOM UND HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP2508169A1

    公开(公告)日：2012-10-10

    申请号：EP10832903.8

    申请日：2010-07-12

    申请人： Shiseido Company, Ltd.

    发明人： SUGIYAMA Yuki ,  OHMORI Takashi ,  KOGA Nobuyoshi

    IPC分类号： A61K8/90 ,  A61K8/14 ,  A61K8/34 ,  A61K8/37 ,  A61K9/127 ,  A61K47/34 ,  A61Q19/00 ,  B01J13/00 ,  B01J13/04

    CPC分类号： A61K8/14 ,  A61K8/11 ,  A61K8/86 ,  A61K9/1273 ,  A61K9/14 ,  A61K2800/75 ,  A61Q19/00 ,  B01J13/02 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/4854 ,  Y10S977/773

    摘要： Provided is a polymersome composition that has skin disorder remedying effects, that is safe, that provides a pleasant feel upon use and a fresh feel without any stickiness, and that has excellent base-agent stability. The disclosed polymersome contains, as a membrane component, a block-type alkylene oxide derivative represented by the following formula (I): R1O-[(EO)l(AO)m(EO)n]-R2. (In the formula, AO represents an oxyalkylene group having 3 or 4 carbons; EO represents an oxyethylene group; m represents an average addition mole number of the oxyalkylene group and satisfies 1=m=70; and 1+n represents an average addition mole number of the oxyethylene group and satisfies 1=1+n=70. The percentage of the oxyethylene group to the sum of the oxyalkylene group having 3 or 4 carbons and the oxyethylene group is 20% to 80% by mass. The oxyalkylene group having 3 or 4 carbons and the oxyethylene group are added blockwise. R1 and R2 each represent a hydrocarbon group having 1 to 4 carbons, which may be the same or different from each other.)

    摘要翻译： 本发明提供了具有皮肤障碍矫正效果的聚合物组合物，其是安全的，其在使用时提供愉悦的感觉和没有任何粘性的新鲜感觉，并且具有优异的基础剂稳定性。 公开的聚合物组合物包含作为膜组分的由下式（I）表示的嵌段型烯化氧衍生物：R1O - [（EO）1（AO）m（EO）n] -R2。 （式中，AO表示碳原子数为3或4的氧化烯基，EO表示氧化乙烯基，m表示氧化烯基的平均加成摩尔数，满足1 = m = 70，1 + n表示平均加成摩尔 氧化乙烯基数为1〜1 + n = 70，氧化乙烯基相对于3或4个碳原子的氧化烯基与氧化乙烯基的和的比例为20〜80质量％，氧化亚烷基的 3或4个碳，氧乙烯基分别加成，R1和R2各自表示碳原子数1〜4的烃基，可以相同也可以不同。）