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公开(公告)号：EP0752873A4
公开(公告)日：2002-05-15
申请号：EP95911829
申请日：1995-02-21
申请人： MALLINCKRODT INC
发明人： MERTENS JOHN , TOURWE DIRK , CEUSTERS MARC
IPC分类号： A61K51/00 , A61K31/00 , A61K38/00 , A61K49/00 , A61K51/08 , A61P35/00 , C07K1/13 , C07K5/00 , C07K5/06 , C07K7/00 , C07K7/06 , C07K7/08 , C07K17/00
CPC分类号： A61K51/08 , A61K38/00 , A61K51/085 , A61K51/088 , A61K2121/00 , A61K2123/00 , C07K7/083
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22.发明公开
公开(公告)号：EP0776333A1
公开(公告)日：1997-06-04
申请号：EP95920948.0
申请日：1995-05-17
发明人： DEBERNARD, Jean-Jacques , DUBERTRET, Catherine , HELYNCK, Gérard , LEBOUL, Jean , MARTIN, Jean-Paul
CPC分类号： C07K7/06 , C07K5/1016 , C07K7/083
摘要： Novel compounds of formula (I), in which R is a hydroxy, alkyloxy, phenylalkyloxy radical or -NH-CH2-COOH, R' and R'' are the same and are each a hydroxy or methoxy radical and R''' is a hydrogen, bromine, chlorine or iodine atom or a nitro radical. The invention also concerns the salts of said compounds and their use.
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公开(公告)号：EP3891176B1
公开(公告)日：2024-06-05
申请号：EP19812797.9
申请日：2019-12-04
IPC分类号： C07K14/605 , C07K7/08 , C12N15/62 , C07K14/575 , C07K7/22
CPC分类号： C07K7/083 , C07K7/22 , C07K14/575 , C07K14/605 , C07K2319/0020130101 , C07K2319/7420130101 , C07K2319/7520130101
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24.发明公开VINYLSULFONE-BASED 18F-LABELING COMPOSITIONS AND METHODS AND USES THEREOF 审中-公开VINYLSULFONBASIERTE 18F标记组合物及其方法和应用
公开(公告)号：EP2964610A4
公开(公告)日：2016-11-23
申请号：EP14760051
申请日：2014-03-08
发明人： LI ZIBO , CONTI PETER S , LI LIN , WU ZHANHONG , LIU SHUANLONG , SHIVELY JOHN E , HORNE DAVID
IPC分类号： A61K51/08 , C07C317/08 , C07C317/18 , C07K1/13 , C07K7/08
CPC分类号： A61K51/0497 , A61K51/04 , A61K51/082 , A61K51/084 , A61K51/085 , A61K51/088 , C07B2200/05 , C07C317/18 , C07K1/13 , C07K7/083 , C07K7/64
摘要： A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.
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25.发明公开VINYLSULFONE-BASED 18F-LABELING COMPOSITIONS AND METHODS AND USES THEREOF 审中-公开VINYLSULFONBASIERTE 18F标记组合物及其方法和应用
公开(公告)号：EP2964610A1
公开(公告)日：2016-01-13
申请号：EP14760051.4
申请日：2014-03-08
发明人： LI, Zibo , CONTI, Peter, S. , LI, Lin , WU, Zhanhong , LIU, Shuanlong , SHIVELY, John, E. , HORNE, David
IPC分类号： C07C317/08 , C07K1/13
CPC分类号： A61K51/0497 , A61K51/04 , A61K51/082 , A61K51/084 , A61K51/085 , A61K51/088 , C07B2200/05 , C07C317/18 , C07K1/13 , C07K7/083 , C07K7/64
摘要： A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group, wherein said labeling agent is capable of covalently bonding to thiol containing biomolecules such as proteins or peptides. Use of said labeling agents for labeling neurotensin and its variants are also disclosed.
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26.发明公开NOVEL AGONISTS AND ANTAGONISTS OF THE UROTENSINERGIC SYSTEM 审中-公开NEE AGONISTEN UND ANTAGONISTEN DES UROTENSINERGISCHEN SYSTEMS
公开(公告)号：EP2729184A4
公开(公告)日：2015-06-24
申请号：EP12779758
申请日：2012-05-03
申请人： INST NAT RECH SCIENT
CPC分类号： C07K5/10 , A61K38/2228 , A61K51/08 , A61K51/088 , C07K7/02 , C07K7/083 , C07K14/57509 , G01N33/5061 , G01N33/5088 , G01N2333/5751
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27.发明公开
公开(公告)号：EP2651429A4
公开(公告)日：2014-08-20
申请号：EP11848811
申请日：2011-12-14
申请人： NEUROADJUVANTS INC
发明人： WHITE H STEVE , KLEIN BRIAN DONALD , METCALF CAMERON SPENCER , MCDOUGLE DANIEL RYAN , SCHOLL ERIKA ADKINS , SMITH MISTY DANIELLE , BULAJ GRZEGORZ , ZHANG LIUYIN
IPC分类号： A61K38/10 , A61K31/21 , A61K31/216 , A61K31/35 , A61K38/22 , A61K38/31 , A61P25/00 , C07K7/08 , C07K14/575 , C07K14/655
CPC分类号： A61K38/10 , A61K38/2271 , A61K38/31 , A61K47/48215 , A61K47/60 , C07K7/083 , C07K14/57545 , C07K14/655
摘要： Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs.
摘要翻译： 神经肽类似物和组合物，包括神经肽类似物描述英寸 因此，提供了生产和使用的神经肽类似物和组合物，包括一种或多种神经肽类似物的方法。
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公开(公告)号：EP1768951A2
公开(公告)日：2007-04-04
申请号：EP05790012.8
申请日：2005-06-17
发明人： DIX, Thomas, A.
IPC分类号： C07C229/00 , C07C205/00 , C07C57/30 , C07D231/06
CPC分类号： C07C279/14 , A61K38/00 , C07C229/08 , C07C229/12 , C07C257/14 , C07D231/06 , C07D233/46 , C07D233/48 , C07D239/14 , C07K7/083
摘要： This invention relates to non-natural desamino alkyl amino acid compounds, methods of making, and peptides containing these compounds as their N-terminus moieties. A preferred example is neurotensin (8-13) in which the N terminus is an alpha desamino, alpha methyl N,N dimethyl homolysine residue.
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公开(公告)号：EP0606804B1
公开(公告)日：2001-10-04
申请号：EP93403185.7
申请日：1993-12-27
申请人： MARTINEX R & D INC.
CPC分类号： C07K7/083 , A61K38/00 , G01N33/533
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公开(公告)号：EP0738280B1
公开(公告)日：2001-02-14
申请号：EP95909489.7
申请日：1995-02-06
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. , YEDA RESEARCH & DEVELOPMENT COMPANY, LTD. , MOODY, Terry W.
IPC分类号： C07K14/575 , C07K7/08 , A61K38/22 , A61K38/10
CPC分类号： C07K7/083 , A61K38/00 , C07K14/57563
摘要： The present invention relates to a family of peptides encoding antagonists of the vasoactive intestinal peptide (VIP) of formula (I) designed to distinguish multiple receptors that mediate VIP neurotransmission, neurotrophism and cell division. The invention also relates to methods of using these peptides to antagonize VIP-associated activity and function. The invention further relates to pharmaceutical compositions designed to inhibit VIP-associated activity. In formula (I), R and R are members independently selected from the group consisting of hydrogen, C1 to C20 alkyl and C1 to C20 acyl, provided that at least one of R or R is hydrogen; and X and X are members independently selected from the group consisting of naturally occurring amino acids and amino acid mimetics.
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