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21.发明公开METHODS OF TREATING VASCULAR DISEASES USING BROMOCRIPTINE 审中-公开VERFAHREN ZUR BEHANDLUNGVASCUALÄRERKRANKHEITEN MIT BROMOCRIPTIN
公开(公告)号：EP3090745A1
公开(公告)日：2016-11-09
申请号：EP16168477.4
申请日：2008-03-24
申请人： VeroScience LLC
发明人： CINCOTTA, Anthony H
摘要： The present invention is directed to a method of simultaneously treating hypertension, hypertriglyceridemia, a pro-inflammatory state, a pro-coagulative state, and insulin resistance (with or without treating obesity or endothelial dysfunction), associated with or independent from Metabolic Syndrome, as well as vascular disease such as cardiovascular, cerebrovascular, or peripheral vascular disease comprising the step of administering to a patient suffering from such disorders a therapeutically effective amount of a central acting dopamine agonist. In one embodiment, the central acting dopamine agonist is bromocriptine, optionally combined with a pharmaceutically acceptable carrier.
摘要翻译： 本发明涉及一种同时治疗与代谢综合征相关或独立于代谢综合征的高血压，高甘油三酯血症，促炎状态，促凝血状态和胰岛素抵抗（有或没有治疗肥胖或内皮功能障碍）的方法，如 以及诸如心血管，脑血管或外周血管疾病的血管疾病，包括向患有这种病症的患者施用治疗有效量的中枢作用的多巴胺激动剂的步骤。 在一个实施方案中，中枢作用的多巴胺激动剂是溴隐亭，任选与药学上可接受的载体组合。
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公开(公告)号：EP1818029B1
公开(公告)日：2016-09-07
申请号：EP07006505.7
申请日：2002-07-10
申请人： CIMA LABS INC.
CPC分类号： A61K9/0034 , A61K9/025 , A61K9/2054 , A61K9/2081 , A61K31/48
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公开(公告)号：EP1366762B1
公开(公告)日：2015-12-30
申请号：EP02702809.1
申请日：2002-03-07
IPC分类号： A61K9/70 , A61K47/32 , A61K31/48 , A61K31/216
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/216 , A61K31/48 , A61K47/32
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公开(公告)号：EP2793583A4
公开(公告)日：2015-08-12
申请号：EP12860106
申请日：2012-06-22
发明人： COOK ROBERT O , ZHANG JIAN , ARMER THOMAS A
IPC分类号： C07D457/12 , A61K31/48
CPC分类号： C07D457/12 , A61K31/48
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25.发明公开COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES 审中-公开具有激动剂作用生长抑素连接及其用途为医疗目的
公开(公告)号：EP2871179A1
公开(公告)日：2015-05-13
申请号：EP13813151.1
申请日：2013-07-02
发明人： ISHIDA, Akiharu , MATSUSHITA, Takeshi , SEKIGUCHI, Tetsuya , KOMAGATA, Tatsuya , NISHIO, Takuya
IPC分类号： C07D211/58 , A61K31/4184 , A61K31/4418 , A61K31/4427 , A61K31/451 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/48 , A61K31/496 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K38/00 , A61P1/00 , A61P5/06 , A61P43/00 , C07D213/75 , C07D213/82 , C07D235/18 , C07D401/04
CPC分类号： C07D498/04 , A61K31/4184 , A61K31/4418 , A61K31/4427 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/48 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/5383 , A61K45/06 , C07D211/58 , C07D213/75 , C07D213/81 , C07D213/82 , C07D235/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04
摘要： Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist.Since the compound represented by the general formula (I):
[wherein all symbols represent the same meanings as those described in the description] a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.-
26.发明授权PREPARATION OF N-6 DEMETHYLATED, 9-10-DIHYDROLYSERGIC ACID ALKYL ESTERS 有权N-6二甲基丙烯酸9-10-二羟基脂肪酸烷基酯的制备
公开(公告)号：EP2294067B1
公开(公告)日：2015-02-18
申请号：EP09738141.2
申请日：2009-04-28
发明人： CASAR, Zdenko , MESAR, Tomaz
IPC分类号： C07D457/02 , C07D457/04 , C07D457/06 , A61K31/48 , A61P25/00
CPC分类号： C07D457/04 , C07D457/02 , C07D457/06
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27.发明公开
公开(公告)号：EP2658564A4
公开(公告)日：2015-01-14
申请号：EP11853771
申请日：2011-12-29
发明人： FOSSEL ERIC T
IPC分类号： A61K38/00 , A61K9/107 , A61K9/70 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4196 , A61K31/422 , A61K31/4465 , A61K31/48 , A61K31/522 , A61K31/54 , A61K47/10 , A61K47/26 , A61K47/36
CPC分类号： A61K31/4985 , A61K9/0014 , A61K9/06 , A61K9/7023 , A61K31/198 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4196 , A61K31/422 , A61K31/437 , A61K31/4465 , A61K31/454 , A61K31/48 , A61K31/506 , A61K31/513 , A61K31/522 , A61K31/54 , A61K45/06 , A61K47/10 , A61K47/183 , A61K47/26 , A61K47/34 , A61K47/36 , A61K2300/00
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公开(公告)号：EP2819674A2
公开(公告)日：2015-01-07
申请号：EP13754567.9
申请日：2013-02-27
申请人： Eye Therapies LLC
发明人： HORN, Gerald
IPC分类号： A61K31/502 , A61K31/197 , A61K31/165 , A61K31/4164 , A61K31/4168 , A61K39/08 , A61K31/407 , A61K31/4045 , A61K31/48 , A61K31/405 , A61K31/192 , A61K31/4706 , A61K38/28 , A61K31/573 , A61P11/02 , A61P25/00 , A61P37/08 , A61P1/04 , A61P27/16 , A61P25/06 , A61P25/28
CPC分类号： A61K31/498 , A61K9/0043 , A61K31/4174 , A61K47/10
摘要： Pharmaceutical compositions for the treatment of nasal congestion or migraine, wherein the pharmaceutical compositions comprise low concentrations of a super-selective subclass of selective α-2 adrenergic receptor agonists.
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29.发明公开COX-2 INHIBITORS AND RELATED COMPOUNDS, AND SYSTEMS AND METHODS FOR DELIVERY THEREOF 审中-公开COX-2抑制剂和其释放相关化合物的系统和方法
公开(公告)号：EP2658553A4
公开(公告)日：2015-01-07
申请号：EP11854161
申请日：2011-12-29
发明人： FOSSEL ERIC T
IPC分类号： A61K38/00 , A61K9/107 , A61K9/70 , A61K31/365 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4196 , A61K31/422 , A61K31/4465 , A61K31/48 , A61K31/522 , A61K31/54 , A61K31/63 , A61K31/635 , A61K47/10 , A61K47/26 , A61K47/36
CPC分类号： A61K9/0014 , A61K9/00 , A61K9/06 , A61K9/107 , A61K31/198 , A61K31/365 , A61K31/63 , A61K31/635 , A61K47/36 , A61K2300/00
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30.发明公开METHOD OF TREATING METABOLIC DISORDERS AND DEPRESSION WITH DOPAMINE RECEPTOR AGONISTS 有权方法代谢紊乱与多巴胺受体激动剂治疗和抑郁症
公开(公告)号：EP2217073A4
公开(公告)日：2014-01-22
申请号：EP08780943
申请日：2008-06-23
申请人： VEROSCIENCE LLC
发明人： CINCOTTA ANTHONY H
CPC分类号： A61K31/4985 , A61K31/00 , A61K31/48 , A61K45/06 , A61L2300/00 , A61K2300/00
摘要： This invention relates to methods and formulations for treating metabolic disorders and depression. In some embodiments, the methods comprise administering a dopamine receptor agonist and an anti-depressant.
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