摘要:
Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of their use in poultry vaccines.
摘要:
Provided herein are modified infectious largotracheitis viruses (ILTVs) and methods of using the same. For example, provided are attenuated ILTVs. The attenuated ILTVs can be used to illicit immune responses in avian species. Optionally, the attenuated ILTVs can be used to vaccinate an avian subject or a population of avian subjects. Optionally, an attenuated ILTV is administered in ovo to an avian egg. One or more such in ovo administration can be used to increase the immunity of an avian herd.
摘要:
A recombinant herpesvirus having a DNA encoding a polypeptide which comprises 429 amino acids in the amino terminal side of a protein encoded by infective pharyngeal bronchitis virus gB gene or a polypeptide derived therefrom by deletion, addition or substitution of one or more amino acids (excluding infective pharyngeal bronchitis virus).
摘要:
The present invention relates to combination vaccines and methods for treating or preventing diseases or disorders in an animal caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory 5 Syncytial Virus (BRSV), Parainfluenza Virus (P13), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira hardj-prajitno, Leptospira icterohaemmorrhagiae, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a combination vaccine. The combination vaccine can be a whole or partial cell inactivated or modified live preparation.
摘要:
Deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene. The mutant may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene. Recombinant nucleic acid which comprises the gE-gene or a part thereof. Glycoprotein gE, peptides based thereon and complexes of the glycoproteins gE and gI, and antibodies against them. Vaccines and diagnostic kits comprising any one of these materials.
摘要:
The present invention discloses liquid stable bovine vaccines that comprise a live attenuated virus, and a sugar alcohol. The present invention also discloses the manufacture of such vaccines and methods of protecting an animal by administration of such vaccines.
摘要:
A safe live recombinant virus as well as a vaccine is produced by the deletion of a portion of the native glycoprotein E(gE) coding region of bovine herpesvirus 1(BHV-1) followed by the insertion of a plasmid including a foreign functional β-gal at the gE locus. The deletion of gE gene stably attenuates the virus and serves as an immunological marker differentiating vaccinated animals from infected animals. Moreover, production of β-gal allows easy assessment of gEΔ3.1IBRβ virus replication in vaccinated animals and serves as a phenotypic marker which distinguishes it from wild type virus replication in infected animals.