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163 条记录 (耗时 0.023 秒)

    ANTICONVULSANT AND CENTRAL NERVOUS SYSTEM-ACTIVE BIS(FLUOROPHENYL)ALKYLAMIDES
    36.
    发明公开
    ANTICONVULSANT AND CENTRAL NERVOUS SYSTEM-ACTIVE BIS(FLUOROPHENYL)ALKYLAMIDES 审中-公开
    抗惊厥和中枢神经系统活性的双FLUOROALKYLAMIDE

    公开(公告)号：EP1640359A3

    公开(公告)日：2006-04-05

    申请号：EP05024236.1

    申请日：1998-12-09

    申请人： NPS PHARMACEUTICALS, INC.

    发明人： Balandrin, Manuel F. ,  Artman, Linda D. ,  Smith, Daryl ,  Vanwagenen, Bradford C. ,  Mueller, Alan L.

    IPC分类号： C07C233/11 ,  A61K31/16 ,  A61P25/00

    CPC分类号： C07C233/11 ,  C07C57/58 ,  C07C233/22 ,  C07C233/51

    摘要： Bis(Fluorophenyl)alkylamides have been chemically synthesized which possess beneficial pharmacological properties (e.g., anticonvulsant activity) useful for the treatment of neurological disease or disorders, such as, for example, epilepsy, convulsions, and seizure disorders. The preferred compounds of the invention also cause little sedation and have high therapeutic and protective indices in animal models of epilepsy. These compounds further possess long pharmacologic half-lives, which, in practical clinical therapeutic application, should translate into once-a-day dosing, of great benefit to patients suffering from these diseases and/or disorders. These compounds may also be of further clinical utility in the treatment of other diseases and disorders of the central and peripheral nervous systems, or diseases or disorders affected by them, including, but not limited to, spasticity, skeletal muscle spasms and pain, restless leg syndrome, anxiety and stress, and bipolar disorder.

    Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    39.
    发明公开
    Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开
    HETEROPOLYCYCLISCHE VERBINDUNGEN UND IHRE VERWENDUNG ALS ANTAGONISTEN VON METABOTROPEN GLUTAMATREZEPTOREN

    公开(公告)号：EP1582519A2

    公开(公告)日：2005-10-05

    申请号：EP05014788.3

    申请日：2000-08-18

    申请人： NPS PHARMACEUTICALS, INC.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07D413/04 ,  C07D401/04 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61P25/00

    CPC分类号： C07D401/04 ,  C07D413/04

    摘要： Compound of formula (II) wherein X, Y, and Z are independently selected form the group consisting of N, O, S, C, and CO wherein at least one of X, Y, and Z is a heteroatom; Ar 1 and Ar 2 are independently selected from the group consisting of a heterocyclic or fused heterocyclic moiety and an aromatic moiety; act as antagonist at metabotropic glutamate receptors, and are useful for treating neurological diseases and disorders.

    摘要翻译： 其中X，Y和Z独立选自由N，O，S，C和CO组成的组的式（II）化合物，其中X，Y和Z中的至少一个为 杂原子 Ar 1和Ar 2独立地选自杂环或稠合杂环部分和芳族部分; 作为代谢型谷氨酸受体的拮抗剂，可用于治疗神经系统疾病和病症。