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公开(公告)号：EP1494701A4
公开(公告)日：2006-09-06
申请号：EP03714400
申请日：2003-03-24
申请人： GPC BIOTECH AG
发明人： NAGY ZOLTAN , BRANDSTETTER TILMANN
IPC分类号： A61K38/00 , A61K38/03 , A61K45/00 , A61P1/12 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/14 , A61P5/40 , A61P7/04 , A61P7/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P37/06 , A61P43/00 , C07K4/00 , C07K5/065 , C07K5/087 , C07K5/107 , C07K7/02 , C07K7/06 , C07K7/08 , A61K39/00 , C07K5/10 , C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , C07K5/06078 , C07K5/0812 , C07K5/1016 , C07K7/02
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公开(公告)号：EP1694670A1
公开(公告)日：2006-08-30
申请号：EP04803982.0
申请日：2004-12-16
申请人： GPC Biotech AG
发明人： EIKHOFF, Jan, Eike , ASHTON, Mark Richard , COURTNEY, Stephen Martin , YARNOLD, Christopher John , VARRONE, Maurizio , LOKE, Pui Leng , HERGET, Thomas , SCHWAB, Wilfried , HAFENBRADL, Doris
IPC分类号： C07D403/12 , C07D409/14 , C07D401/04 , C07D241/20 , A61K31/4965 , A61K31/497
CPC分类号： C07D401/04 , C07D241/20 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention relates to pyrazine derivatives according to the general formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceutical compounds as well as the use of these compounds for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases, stroke and especially for the treatment of herpesviral induced infections, including opportunistic infections as well as infections and diseases caused by human cytomegalovirus (HCMV).
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33.发明公开Immunomodulatory human MHC class II antigen-binding peptides/proteins 审中-公开免疫模型人类MHC Klasse II抗原结合肽/蛋白质
公开(公告)号：EP1156062A1
公开(公告)日：2001-11-21
申请号：EP00110063.5
申请日：2000-05-12
申请人： GPC Biotech AG , MorphoSys AG
IPC分类号： C07K16/28 , C12N15/13 , C12N1/21 , C12N5/10 , C12N15/70 , C12N15/85 , A61K39/395 , A61P37/00 , G01N33/68 , G01N33/53 , G01N33/577 , C12Q1/68
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , Y02A50/416
摘要： The present invention relates to human peptides/proteins comprising at least one antibody-based antigen-binding domain of human composition with a binding specificity for a human MHC class II antigen, wherein binding of said peptide/protein to said antigen expressed on the surface of a cell causes or leads to modulation of the immune system. The invention further relates to nucleic acids encoding said peptides/proteins, methods for production, immunosuppression, pharmaceutical and diagnostic compositions or kits comprising the peptides/proteins and uses of the peptides/proteins.
摘要翻译： 本发明涉及包含人类组合物的至少一种基于抗体的抗原结合结构域，对人类MHC II类抗原具有结合特异性的人肽/蛋白质，其中所述肽/蛋白质与所述抗原表面上表达的所述抗原结合 细胞引起或导致免疫系统的调节。 本发明还涉及编码所述肽/蛋白质的核酸，生产方法，免疫抑制，药物和诊断组合物或包含肽/蛋白质的试剂盒和肽/蛋白质的用途。
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公开(公告)号：EP1364212B1
公开(公告)日：2011-02-02
申请号：EP02723332.9
申请日：2002-03-04
申请人： GPC Biotech AG , GPC Biotech Inc.
IPC分类号： G01N33/566 , A61K31/01 , C07K14/00 , C12Q1/00 , C12N15/62
CPC分类号： C40B30/04 , C07D231/54 , C07D487/04 , C07F9/65583 , C07F9/6561 , G01N33/6845 , G01N2500/10
摘要： The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.
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35.发明公开SECOND LINE TREATMENT OF METASTATIC HORMONE REFRACTORY PROSTATE CANCER USING SATRAPLATIN 审中-公开转移激素难治性前列腺癌赛特铂方治疗
公开(公告)号：EP2066311A2
公开(公告)日：2009-06-10
申请号：EP07820518.4
申请日：2007-09-24
申请人： GPC Biotech AG
IPC分类号： A61K31/136 , A61K31/337 , A61K31/475 , A61K31/56 , A61K31/57 , A61K31/565 , A61K31/573 , A61K33/24 , A61P35/00 , A61P13/08
CPC分类号： A61K33/24 , A61K31/136 , A61K31/137 , A61K31/282 , A61K31/337 , A61K31/475 , A61K31/56 , A61K31/565 , A61K31/57 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The instant invention relates to methods using satraplatin, packaged-pharmaceutical-products that include satraplatin and uses of satraplatin to prepare pharmaceutical compositions for the 2nd line treatment of metastatic hormone refractory prostate cancer.
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公开(公告)号：EP1674457B1
公开(公告)日：2009-06-03
申请号：EP04030696.1
申请日：2004-12-23
申请人： GPC Biotech AG
IPC分类号： C07D213/74 , C07D401/12 , A61K31/4406 , A61K31/4409 , A61P35/00
CPC分类号： C07D213/74 , C07D401/12
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公开(公告)号：EP1975620A2
公开(公告)日：2008-10-01
申请号：EP08103127.0
申请日：2002-03-04
申请人： GPC Biotech AG , GPC Biotech Inc.
IPC分类号： G01N33/566 , A61K31/01 , C07K14/00 , C12Q1/00 , C12N15/62
CPC分类号： C40B30/04 , C07D231/54 , C07D487/04 , C07F9/65583 , C07F9/6561 , G01N33/6845 , G01N2500/10
摘要： The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hypbrid ligand compounds.
摘要翻译： 本发明提供了用于分离用户特异性配体的配体结合多肽并且使用改进的一类hypbrid配体化合物分离用于用户特异性目标多肽的小分子配体的组合物和方法。
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38.发明公开Methods for treating resistant or refractory tumors 审中-公开Verfahren zur Behandlung von resistenten undrefraktärenTumoren
公开(公告)号：EP1967189A1
公开(公告)日：2008-09-10
申请号：EP08102968.8
申请日：2005-02-18
申请人： GPC Biotech AG
IPC分类号： A61K31/282 , A61P35/00 , A61K33/24
CPC分类号： A61K45/06 , A61K31/282 , A61K31/555 , A61K33/24 , A61K2300/00
摘要： The instant invention relates to methods, pharmaceutical compositions and packaged pharmaceuticals for treating resistant or refractory tumors by administering platinum-based compounds.
摘要翻译： 本发明涉及通过施用铂类化合物来治疗耐药性或难治性肿瘤的方法，药物组合物和包装药物。
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公开(公告)号：EP1720540B1
公开(公告)日：2008-06-11
申请号：EP05715410.6
申请日：2005-02-18
申请人： GPC Biotech AG
IPC分类号： A61K31/282 , A61P35/00 , A61K33/24
CPC分类号： A61K45/06 , A61K31/282 , A61K31/555 , A61K33/24 , A61K2300/00
摘要： The instant invention relates to methods, pharmaceutical compositions and packaged pharmaceuticals for treating resistant or refractory tumors by administering platinum-based compounds.
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40.发明公开Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues 审中-公开抗增殖性Kombinationstherapie mit einem Platin enthaltenden chemotherapeuticchen Mittel und EGFR-Inhibitoren oder Pyrimidinanaloga
公开(公告)号：EP1792622A1
公开(公告)日：2007-06-06
申请号：EP05024701.4
申请日：2005-11-11
申请人： GPC Biotech AG
发明人： Wosikowski-Buters, Katja , Schaab, Christoph , Schuhmacher, Marino , Obermayr, Franz , Ivanov, Igor
IPC分类号： A61K33/24 , A61K31/505 , A61P35/00
CPC分类号： A61K31/555 , A61K31/505 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： This invention relates to a method or uses of prevention and/or treatment of a cancer or a tumor, and in particular to a combination therapy, methods, compositions and pharmaceutical packages comprising an inhibitor or receptors of the EGFR family or a chemotherapeutically active pyrimidine analogue and certain platinum-based chemotherapeutic agents.
摘要翻译： 本发明涉及预防和/或治疗癌症或肿瘤的方法或用途，特别涉及包含EGFR家族的抑制剂或受体的组合疗法，方法，组合物和药物包装或化学治疗活性嘧啶类似物 和某些铂类化疗药。
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