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公开(公告)号：EP2331133A2
公开(公告)日：2011-06-15
申请号：EP09811854.0
申请日：2009-09-08
申请人： Duke University
IPC分类号： A61K39/395 , A61P31/18
CPC分类号： C07K16/44 , C07K16/28 , C07K2317/21 , C07K2317/76
摘要： The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.
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公开(公告)号：EP2265732A2
公开(公告)日：2010-12-29
申请号：EP09733216.7
申请日：2009-04-15
发明人： GOLDSTEIN, David, B. , TELENTI, Amalio , FELLAY, Jacques , SHIANNA, Kevin, V. , GE, Dongliang , HAYNES, Barton, F. , NEED, Anna
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to genetic variants associated with restriction of HIV disease progression.
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33.发明公开METHOD OF INDUCING NEUTRALIZING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS 审中-公开VERFAHREN ZUR INDUZIERUNG中性粒细胞抗体
公开(公告)号：EP2139516A1
公开(公告)日：2010-01-06
申请号：EP08742782.9
申请日：2008-04-11
申请人： Duke University
IPC分类号： A61K39/21 , A61K39/385
CPC分类号： A61K39/21 , A61K39/12 , A61K39/385 , A61K47/6911 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/575 , A61K2039/6018 , A61K2039/62 , A61K2039/625 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K16/1063 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
摘要翻译： 本发明涉及诱导患者抗HIV抗体产生的方法。 该方法包括向有需要的患者施用足以实现该诱导的量的至少一种脂质体 - 肽缀合物。 肽包含膜外接近区（MPER）表位，脂质体包含溶血磷脂酰胆碱或磷脂酰丝氨酸。
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34.发明公开SUBSTANTIALLY NON-TOXIC BIOLOGICALLY ACTIVE MUCOSAL ADJUVANTS IN VERTEBRATE SUBJECTS 审中-公开在脊椎动物中基本上是无毒的生物活性粘膜
公开(公告)号：EP1121147A1
公开(公告)日：2001-08-08
申请号：EP99951772.5
申请日：1999-10-06
申请人： DUKE UNIVERSITY
IPC分类号： A61K39/00 , A61K47/00 , C07K14/52 , C07K14/54 , C07K14/545
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55538 , Y10S514/885
摘要： A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1α (IL-1α) and interleukin-1β (IL-1β).
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35.发明公开SYNTHETIC VACCINE FOR PROTECTION AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION 失效合成疫苗，以对抗感染PROTECT由人类免疫缺陷病毒
公开(公告)号：EP0868196A1
公开(公告)日：1998-10-07
申请号：EP96936830.0
申请日：1996-10-18
申请人： DUKE UNIVERSITY
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , A61K2039/6037 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to immunogenic preparations of peptides comprising amino acid sequences corresponding to antigenic determinants of the envelope glycoprotein of HIV, covalently coupled, directly or through a spacer molecule, to carrier molecules suitable for vaccination of mammals.
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公开(公告)号：EP0830373A1
公开(公告)日：1998-03-25
申请号：EP96913873.0
申请日：1996-04-29
发明人： HAYNES, Barton, F. , ARUFFO, Alejandro , PATEL, Dhavalkumar , BOWEN, Michael, A. , MARQUARDT, Hans
CPC分类号： C07K14/70503 , A61K38/00 , C07K16/2803 , C07K2319/30
摘要： The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction.
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公开(公告)号：EP4388012A1
公开(公告)日：2024-06-26
申请号：EP22859437.0
申请日：2022-08-19
申请人： Duke University , The Chancellor, Masters and Scholars of The University of Oxford , Li, Dapeng , McMichael, Andrew, James , Brackenridge, Simon , Gillespie, Geraldine , Azoitei, Mihai , Walters, Lucy, C. , Saunders, Kevin, O. , Haynes, Barton, F.
发明人： LI, Dapeng , MCMICHAEL, Andrew, James , BRACKENRIDGE, Simon , GILLESPIE, Geraldine , AZOITEI, Mihai , WALTERS, Lucy, C. , SAUNDERS, Kevin, O. , HAYNES, Barton, F.
IPC分类号： C07K16/28 , G01N33/569
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公开(公告)号：EP3794027A1
公开(公告)日：2021-03-24
申请号：EP19802868.0
申请日：2019-05-13
申请人： MacroGenics, Inc. , Duke University
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公开(公告)号：EP3630174A1
公开(公告)日：2020-04-08
申请号：EP18806706.0
申请日：2018-05-25
申请人： Duke University
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公开(公告)号：EP1667714B1
公开(公告)日：2018-01-03
申请号：EP04784298.4
申请日：2004-09-17
申请人： Duke University , The University of Alabama at Birmingham Research Foundation , The Regents of the University of California
发明人： HAYNES, Barton, F. , GAO, Feng , KORBER, Bette, T. , HAHN, Beatrice, H. , SHAW, George, M. , KOTHE, Denise , LI, Ying Ying , DECKER, Julie , LIAO, Hua-Xin
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
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