-
公开(公告)号：EP2890676A4
公开(公告)日：2016-04-20
申请号：EP13834078
申请日：2013-08-29
IPC分类号： C07D207/14 , A61K31/40 , A61K31/428 , A61K31/4439 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号： C07D417/06 , C07D207/14 , C07D401/06 , C07D401/08
摘要： The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
-
32.发明公开SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 有权SEREKTIVE GLYCOSIDASEHEMMER UND IHRE VERWENDUNG
公开(公告)号：EP2723753A4
公开(公告)日：2014-11-26
申请号：EP12804294
申请日：2012-06-27
发明人： LI TONG-SHUANG , MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , ZHU YONGBAO , SELNICK HAROLD G
IPC分类号： C07H9/06 , A61K31/7056 , C07D513/04 , C12Q1/34 , G01N33/50
CPC分类号： C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
-
33.发明公开SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 有权SEREKTIVE GLYCOSIDASEHEMMER UND IHRE VERWENDUNG
公开(公告)号：EP2691407A4
公开(公告)日：2014-08-27
申请号：EP12765063
申请日：2012-03-20
发明人： KAUL RAMESH , MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , LIU KUN , SELNICK HAROLD G , WEI ZHONGYONG , MU CHANGWEI , WANG YAODE , WANG XIAONA
IPC分类号： C07H15/12 , A61K31/7056 , C07H9/06 , C07H11/00 , C07H13/00 , C07H13/12 , C07H15/18 , C07H17/07 , C07H19/04 , C12N9/24 , C12Q1/34
CPC分类号： C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要： The invention provides compounds of formula (I) with substituents as specified in Claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
摘要翻译： 本发明提供了具有如权利要求1中所定义的取代基的式（I）化合物，其用于选择性抑制糖苷酶，化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的过度表达或O-GlcNac的积累有关的疾病和病症的方法。
-
公开(公告)号：EP2655388A4
公开(公告)日：2014-06-18
申请号：EP11850773
申请日：2011-12-21
发明人： KAUL RAMESH , MCEACHERN ERNEST J , MU CHANGWEI , SELNICK HAROLD G , VOCADLO DAVID J , WANG YAODE , WEI ZHONGYONG , ZHOU YUANXI , ZHU YONGBAO
IPC分类号： C07H9/06 , A61K31/7056 , C07D513/04 , C12Q1/34
CPC分类号： C07H9/06 , C07D513/04 , C07H9/00 , C07H17/00 , C12Q1/34 , G01N2333/924 , G01N2500/04 , G01N2500/20
摘要： The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
-
公开(公告)号：EP2569291A4
公开(公告)日：2013-10-16
申请号：EP11780012
申请日：2011-05-10
发明人： LI TONG-SHUANG , MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , ZHU YONGBAO , LIU KUN , SELNICK HAROLD G
IPC分类号： C07D263/52 , A61K31/423 , A61K31/428 , A61P25/28 , C07D263/54 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04 , C12Q1/34
CPC分类号： C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
-
公开(公告)号：EP2331101A4
公开(公告)日：2012-08-29
申请号：EP09812085
申请日：2009-08-31
申请人： MERCK SHARP & DOHME
发明人： BELL IAN M , SELNICK HAROLD G
IPC分类号： C07D417/14 , A61K31/537 , A61K31/553 , C07D471/04 , C07D471/10
CPC分类号： C07D471/04 , C07D417/14 , C07D471/10
-
37.发明公开NON-AMIDIC LINKERS WITH BRANCHED TERMINI AS CGRP RECEPTOR ANTAGONISTS 有权与支化非酰胺BINDER ENDS AS CGRP受体拮抗剂的
公开(公告)号：EP2326176A4
公开(公告)日：2012-02-29
申请号：EP09808605
申请日：2009-08-11
申请人： MERCK SHARP & DOHME
发明人： WOOD MICHAEL R , KIM JUNE J , SELNICK HAROLD G , STACHEL SHAWN J
IPC分类号： C07D471/04 , A61K31/437 , A61P25/06 , C07D235/02 , C07D471/20
CPC分类号： C07D471/04 , C07D235/02 , C07D471/20
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.012 秒)
