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公开(公告)号：EP2571512B1
公开(公告)日：2017-08-23
申请号：EP11783865.6
申请日：2011-05-17
发明人： GREGORY, Philip, D. , MILLER, Jeffrey, C. , PASCHON, David , REBAR, Edward, J. , TAN, Siyuan , URNOV, Fyodor , ZHANG, Lei
IPC分类号： A61K38/00 , A61K38/16 , C12N15/62 , C12N9/22 , C07K14/195
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了包含新型DNA结合结构域的多肽，编码多核苷酸的细胞和生物体，包括TALE DNA结合结构域。 还公开了使用这些新的DNA结合结构域调节内源性细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：EP3156062A1
公开(公告)日：2017-04-19
申请号：EP16200664.7
申请日：2011-05-17
发明人： GREGORY, Philip D. , MILLER, Jeffrey C. , PASCHON, David , REBAR, Edward J. , TAN, Siyuan , URNOV, Fyodor , ZHANG, Lei
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合域）的细胞和生物体的多肽，多核苷酸。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：EP3070169A1
公开(公告)日：2016-09-21
申请号：EP16163183.3
申请日：2007-12-13
发明人： CAI, Qihua C. , MILLER, Jeffrey , URNOV, Fyodor , SHUKLA, Vipula K. , PETOLINO, Joseph F. , BAKER, Lisa W. , GARRISON, Robbi J. , BLUE, Ryan C. , MITCHELL, Jon C. , ARNOLD, Nicole L. , WORDEN, Sarah E.
CPC分类号： C07K14/4702 , C07K2319/81 , C12N15/8213 , C12N15/8243
摘要： Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also disclosed are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulations are also described.
摘要翻译： 本文公开了包含CCHC锌配位残基的锌指。 还公开了锌指蛋白和包含这些CCHC锌指的融合蛋白以及编码这些蛋白的多核苷酸。 还描述了使用这些蛋白质进行基因编辑和基因规则的方法。
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公开(公告)号：EP2890780A2
公开(公告)日：2015-07-08
申请号：EP13833658.1
申请日：2013-08-29
发明人： COST, Gregory J. , GREGORY, Philip D. , GUSCHIN, Dmitry , HOLMES, Michael C. , MILLER, Jeffrey C. , PASCHON, David , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor , ZHANG, Lei
IPC分类号： C12N5/071
摘要： Disclosed herein are nucleases and methods of using these nucleases for alteration of a globin gene and generation of cells.
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公开(公告)号：EP2780460A1
公开(公告)日：2014-09-24
申请号：EP12850371.1
申请日：2012-11-16
发明人： GREGORY, Philip D. , MILLER, Jeffrey C. , PASCHON, David , REBAR, Edward J. , TAN, Siyuan , URNOV, Fyodor , ZHANG, Lei
IPC分类号： C12N15/87 , C07K14/195
CPC分类号： C07K14/195 , C07K2319/80 , C12N1/16 , C12N5/04 , C12N5/0602 , C12N9/1007 , C12N9/22 , C12N15/63 , C12N15/902 , C12N15/907 , C12P19/34 , C12Y301/21004
摘要： Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
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36.发明公开METHODS AND COMPOSITIONS FOR MODIFICATION OF THE HPRT LOCUS 有权VERFAHREN UND ZUSAMMENSETZUNGEN ZURVERÄNDERUNGDES HPRT-LOCUS
公开(公告)号：EP2771457A2
公开(公告)日：2014-09-03
申请号：EP12844270.4
申请日：2012-10-25
发明人： COST, Gregory J. , HOLMES, Michael C. , KASAHARA, Noriyuki , LAGANIERE, Josee , MILLER, Jeffrey C. , PASCHON, David , REBAR, Edward J. , URNOV, Fyodor , ZHANG, Lei
CPC分类号： C12N15/85 , C07K2319/81 , C12N9/1077 , C12N9/22 , C12N9/96 , C12N15/907 , C12Y204/02008 , C12Y301/21004
摘要： Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
摘要翻译： 使用这些核酸酶修饰HPRT基因座的核酸酶和方法，并增加靶向位点和克隆以及产生动物的基因修饰频率。
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公开(公告)号：EP2764102A1
公开(公告)日：2014-08-13
申请号：EP12838704.0
申请日：2012-10-04
IPC分类号： C12N15/55 , A61K31/7088
CPC分类号： C12N15/85 , A61K31/7088 , A61K31/7105 , A61K31/713 , C07K2/00 , C07K2319/81 , C12N9/16 , C12N15/87 , C12Y301/21004
摘要： Methods and compositions for regulating HIV infection and/or replication in which an anti-HIV transgene is integrated into the genome of a cell using a nuclease.
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公开(公告)号：EP2137310B1
公开(公告)日：2010-11-24
申请号：EP08743239.9
申请日：2008-04-24
CPC分类号： C12N15/907 , C07K14/435 , C07K14/43595 , C07K2319/81 , C12N9/22 , C12N15/1082 , C12N15/113 , C12N2800/10 , C12N2800/30 , C12Y301/21004
摘要： Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.
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39.发明公开ENGINEERED ZINC FINGER PROTEINS TARGETING 5-ENOLPYRUVYL SHIKIMATE-3-PHOSPHATE SYNTHASE GENES 有权技术设计为与基因锌指蛋白FOR 5-烯醇丙酮莽草酸-3-磷酸合酶作为目的地
公开(公告)号：EP2205749A1
公开(公告)日：2010-07-14
申请号：EP08833882.7
申请日：2008-09-25
CPC分类号： C12N15/8213 , C07K2319/00 , C07K2319/81 , C12N9/1092 , C12N15/8243 , C12N15/8274
摘要： The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes.
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公开(公告)号：EP2205729A2
公开(公告)日：2010-07-14
申请号：EP08833574.0
申请日：2008-09-25
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/40 , A01K2267/03 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N2800/80
摘要： Disclosed herein are methods and compositions for genomic editing of one or more genes in zebrafish, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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