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41.发明公开MATERIALS, METHODS AND DEVICES FOR ALTERING CELL REACTIVITY 审中-公开MATERIALIEN，VERFAHREN UND VORRICHTUNGEN ZURVERÄNDERUNGDERZELLREAKTIVITÄT
公开(公告)号：EP3096748A1
公开(公告)日：2016-11-30
申请号：EP15704426.4
申请日：2015-01-26
发明人： SLEPIAN, Marvin J.
IPC分类号： A61K31/10 , C12N5/078 , A61K31/165 , A61K31/202
CPC分类号： A61K31/10 , A61K31/165 , A61K31/202 , A61K31/337 , A61K31/407 , A61K31/575 , A61K31/685 , A61K35/19 , A61M1/10 , C12N5/0006 , C12N5/0644 , C12N2500/36 , C12N2500/62
摘要： Methods, compositions, and devices to limit, modulate, insulate, and/or otherwise alter the effects of exogenous physical stimuli on cells are described herein. The cells may be removed from the body, preferably isolated, and treated ex vivo with the composition to limit the effects of physical stimuli on the cells and then returned to the patient. Alternatively, the cells may be treated in vivo. The compositions can be administered a variety of manners, such as systemically, locally or regionally.
摘要翻译： 本文描述了限制，调节，绝缘和/或以其它方式改变外源物理刺激对细胞的作用的方法，组合物和装置。 细胞可以从体内移除，优选分离，并且用组合物离体处理以限制物理刺激对细胞的影响，然后返回到患者体内。 或者，可以在体内处理细胞。 组合物可以以各种方式施用，例如全身，局部或区域。
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公开(公告)号：EP2920193A1
公开(公告)日：2015-09-23
申请号：EP13855794.7
申请日：2013-09-30
摘要： The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound.
摘要翻译： 本发明提供了基于碳水化合物的表面活性剂及其制备方法。 制备碳水化合物基表面活性剂的方法包括使用糖基化启动子将碳水化合物或其衍生物与疏水化合物连接。
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43.发明授权
公开(公告)号：EP2344892B1
公开(公告)日：2014-05-21
申请号：EP09740779.5
申请日：2009-09-30
发明人： CHERRINGTON, Nathan
IPC分类号： G01N33/94
CPC分类号： G01N33/9486 , G01N2400/00 , G01N2440/38 , G01N2800/08 , G01N2800/085 , G01N2800/52
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公开(公告)号：EP2609930A2
公开(公告)日：2013-07-03
申请号：EP13156164.9
申请日：2007-02-27
IPC分类号： A61K38/18
CPC分类号： A61K38/1883
摘要： Disclosed are methods of improving impaired proprioception, treating brachial plexus injuries, regenerating large and small nerve fibers, treating dorsal root nerve injuries, and improving sensory neural responses in a subject by administration of a neublastin polypeptide.
摘要翻译： 公开了改善本发明受损的方法，治疗臂丛神经损伤，再生大小神经纤维，治疗背根神经损伤，以及通过施用新斯的斯多肽多肽来改善受试者的感觉神经反应。
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45.发明公开
公开(公告)号：EP2547660A1
公开(公告)日：2013-01-23
申请号：EP11711417.3
申请日：2011-03-18
申请人： The United States Of America, As Represented By The Secretary, Department of Health and Human Services , The Arizona Board Of Regents On Behalf Of The University of Arizona
发明人： MIRANDA, Katrina M. , WINK, David A. , SALMON, Debra J. , BASUDHAR, Debashree , KEEFER, Larry K. , SAAVEDRA, Joseph E. , ANDREI, Daniela
IPC分类号： C07D231/16 , C07D261/12 , C07D327/04 , C07D417/12 , C07D513/04 , C07D515/04 , A61K31/15 , A61P35/00
CPC分类号： C07D261/12 , C07D231/16 , C07D327/04 , C07D417/12 , C07D513/04 , C07D515/04
摘要： Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof:(I) in which R
1 , R
2 , R
3 , and R
4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).-
公开(公告)号：EP2415130A1
公开(公告)日：2012-02-08
申请号：EP10718461.6
申请日：2010-03-31
申请人： Humboldt Universität zu Berlin , The Arizona Board Of Regents On Behalf Of The University of Arizona
CPC分类号： H01S3/0675 , H01S3/0809 , H01S3/10046 , H01S3/1028 , H01S3/1061 , H01S3/1109 , H01S3/1112
摘要： An embodiment of the invention relates to a multi-segment all-fiber laser device (10). The device includes a first active fiber laser segment (20), a first grating (25), a second grating (35), and a gain-phase coupling fiber segment (40) arranged between the first and second gratings, said gain-phase coupling segment providing coupling of gain and phase between said first and second gratings. The second grating may be provided in a second active fiber laser segment (30) and the phase may be adjusted by a control pump source (70).
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公开(公告)号：EP2381788A2
公开(公告)日：2011-11-02
申请号：EP10732041.8
申请日：2010-01-13
IPC分类号： A01N63/02 , A01N63/00 , A01P1/00 , A01P3/00 , A61K38/16 , C07K19/00 , C12N15/62 , C12N15/867 , A61K39/44 , C07K16/00
CPC分类号： C07K16/20 , A01K2217/052 , A01K2217/206 , A01K2227/101 , A01K2267/01 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00 , C07K2319/01 , C07K2319/035 , C12N2740/13043 , Y02A50/488
摘要： The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.
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48.发明授权SUPPRESSION OF RESISTANCE IN INSECTS TO BACILLUS THURINGIENSIS CRY TOXINS, USING TOXINS THAT DO NOT REQUIRE THE CADHERIN RECEPTOR 有权性的昆虫对苏云金芽孢杆菌，CRY毒素法抑制毒素并不需要钙黏着蛋白受体
公开(公告)号：EP2184293B1
公开(公告)日：2011-10-12
申请号：EP07747214.0
申请日：2007-06-08
申请人： UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO , The Arizona Board of Regents on behalf of the University of Arizona
发明人： PARDO-LÓPEZ, Liliana , TABASHNIK, Elliot Bruce , SOBERÓN-CHAVÉZ, Mario , BRAVO-DE LA PARRA, María Alejandra
CPC分类号： C12N15/8286 , C07K14/325 , Y02A40/162
摘要： The invention relates to a method for obtaining DNA constructions coding for Cry toxins with 3 domains (also known as Cry toxins, Bt toxins or ´-endotoxins), which lack helix ±-1. Said DNA constructions were modified in order to encode proteins that can kill insects that are resistant to the corresponding non-modified Cry toxins. The invention relates to the DNA constructions of the genes of modified 3-domain Cry toxins and the modified 3-domain Cry proteins, together with methods, molecular vectors and host cells containing said constructions, as well as recombinant methods for producing the modified 3-domain Cry toxins. In addition, the invention relates to formulations containing the modified 3-domain Cry toxins. Resistance of insects to non-modified Cry toxins is due to a reduced binding of the toxin to the receptors in the insect's intestine. More specifically, the invention relates to the expression of the modified 3-domain Cry toxins, the methods for expressing said modified 3-domain Cry toxins, transformed microorganisms and transgenic plants with constructions that express the modified 3-domain Cry toxins and methods for suppressing resistance of pests to non-modified Cry toxins.
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49.发明公开Method for inhibiting metastasis in a stem cell fusion model of carcinogenesis 有权方法zen Inhibierung von Metastasen in einem Stammzellenfusionsmodell von Karzinogenese
公开(公告)号：EP2363146A1
公开(公告)日：2011-09-07
申请号：EP11165870.4
申请日：2006-08-25
IPC分类号： A61K39/395 , C07K16/30 , A61P35/04
CPC分类号： C07K16/18 , A61K2039/505 , C12N5/16 , G01N33/5011
摘要： Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell ( Fig. 1 ). Antibodies against ubiquitin are shown to inhibit tumor cell migration.
摘要翻译： 用于建模癌细胞迁移的方法，筛选药物对肿瘤细胞迁移的影响，以及检测与骨髓来源的干细胞与遗传改变细胞融合相关的肿瘤细胞迁移的潜力（图1）。 显示抗泛素的抗体抑制肿瘤细胞迁移。
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公开(公告)号：EP1545195B1
公开(公告)日：2011-08-17
申请号：EP03791900.8
申请日：2003-08-29
IPC分类号： A01K67/00
CPC分类号： G01N33/5088
摘要： The present invention relates to an animal model for human perimenopause and menopause. Also provided by the present invention are methods of making the animal model and methods of screening using the model. Also provided are methods of inducing ovarian failure in animals such as pets and wildlife.
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