摘要:
The present invention is a process for the preparation of 2′-deoxy-5-trifluoromethyl-β-uridine characterized in that a 5-trifluoromethyyl-2,4-bis(triorganosilyloxy)pyrimidine and a 1-halogeno-2-deoxy-alpha-D-erythro-pentofuranose derivative are subjected to a condensation reaction to give a 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivative which is then subjected to a deprotection reaction to give 2′-deoxy-5-trifluoromethyl-β-uridine.
摘要:
This invention relates to 1,2-dichloro-1,2,2-trimethyl-1-phenyldisilane expressed by the chemical formula (II), Cl(CH₃)₂SiSi(CH₃)(C₆H₅)Cl. This invention further relates to a method for producing 1,2-dichloro-1,2,2-trimethyl-1-phenyl disilane by reacting phenyl lithium with 1,1,2-trichloro-1,2,2-trimethyldisilane expressed by the chemical formula (III), Cl(CH₃)₂SiSi(CH₃) Cl₂. This invention still further relates to a method for producing 1,2-dichloro-1,2,2-trimethyl-1-phenyl disilane by reacting 1,1,2-trichloro-1,2,2-trimethyl disilane with phenyl magnesium halide expressed by the general formula (IV), C₆H₅MgX (X = halogen atom) in the presence of a cobalt catalyst.
摘要:
The object of the present invention is to provide a pharmaceutical agent which activate mitochondrial function, particularly, an inexpensive pharmaceutical agent. The problem can be solved by a mitochondrial function activator of the present invention, comprising β-alanine or glycine, or a salt thereof.
摘要:
The object of the present invention is to provide a method for preparing 4-(piperidin-4-yl)morpholine, which is easy to operate. The object can be solved by a method for preparing 4-(1-benzylpiperidin-4-yl)morpholine, characterized in that 5-fold molar or more of morpholine is added to 1-benzyl-4-piperidone, and the mixture is reacted with hydrogen under 1 MPa or less in the presence of platinum catalyst or palladium catalyst.
摘要:
A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2'-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2'-deoxyguanosine is prepared.