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公开(公告)号:EP3191520B1
公开(公告)日:2020-01-01
申请号:EP15770739.9
申请日:2015-09-11
申请人: Genentech, Inc.
发明人: ZHENG, Bing , POLSON, Andrew , CHIU, Cecilia , LIANG, Wei-Ching , WU, Yan
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公开(公告)号:EP3299391A1
公开(公告)日:2018-03-28
申请号:EP17197596.4
申请日:2014-03-13
申请人: Genentech, Inc.
发明人: LEONG, Steven R. , POLSON, Andrew , POLAKIS, Paul , WU, Yan , LIANG, Wei-Chang , FIRESTEIN, Ron
IPC分类号: C07K16/28 , A61P35/00 , A61K39/395
CPC分类号: C07K16/2827 , A61K38/08 , A61K39/39558 , A61K47/65 , A61K47/6801 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K51/1051 , A61K2039/505 , C07K16/3015 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/56972
摘要: The disclosure provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
摘要翻译: 本公开提供了抗B7-H4抗体和免疫缀合物以及使用它们的方法。
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公开(公告)号:EP3181147A1
公开(公告)日:2017-06-21
申请号:EP16197439.9
申请日:2007-11-20
申请人: Genentech, Inc.
发明人: GURNEY, Austin, L , BALAZS, Mercedesz , GHILARDI, Nico , HYMOWITZ, Sarah , HASS, Philip, E , STAROVASNIK, Melissa, A , WU, Yan , LEE, James, M , ARNOTT, David, P , OUYANG, Wenjun
CPC分类号: C07K16/244 , A61K38/2073 , A61K2039/505 , C07K14/54 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/40 , G01N2500/10 , G01N2800/24 , Y02A50/463
摘要: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译: 本发明涉及一种新的天然存在的人细胞因子,其由白介素17和白细胞介素17F的异二聚体组成,在本文中称为白细胞介素17A / F(IL-17A / F)。 本文还提供了包含那些核酸序列的载体和宿主细胞,包含与异源多肽序列融合的本发明多肽的嵌合多肽分子,结合本发明多肽的特异性抗体以及用于产生本发明多肽的方法 本发明。 本文进一步提供了用于治疗退行性软骨病症和其他炎性疾病的方法。
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公开(公告)号:EP3156418A1
公开(公告)日:2017-04-19
申请号:EP16185311.4
申请日:2007-01-04
申请人: GENENTECH, INC.
发明人: WU, Yan , YAN, Minhong
IPC分类号: C07K16/28 , C07K16/30 , C12N15/13 , C12N15/63 , C12N5/10 , G01N33/53 , A61K39/395 , A61P35/00
CPC分类号: C07K16/2866 , A61K39/0011 , A61K2039/505 , C07K16/30 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要: The invention provides anti-EphB4 anti-bodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供了抗EphB4抗体,以及包含这些抗体的方法和使用这些抗体的方法。
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公开(公告)号:EP2411414B1
公开(公告)日:2015-07-15
申请号:EP10722819.9
申请日:2010-03-24
申请人: Genentech, Inc.
发明人: ASHKENAZI, Avi , QING, Jing , WIESMANN, Christian , WU, Yan
IPC分类号: C07K16/28 , A61K39/395
CPC分类号: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
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公开(公告)号:EP2831118A1
公开(公告)日:2015-02-04
申请号:EP13716131.1
申请日:2013-03-29
申请人: Genentech, Inc.
发明人: HONGO, Jo-Anne , MAO, Weiguang , POLAKIS, Paul , POLSON, Andrew , VIJ, Rajesh , WU, Yan , LIANG, Wei-Ching
CPC分类号: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
摘要: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号:EP1994056B1
公开(公告)日:2014-05-07
申请号:EP07800145.0
申请日:2007-03-16
申请人: Genentech, Inc.
发明人: YE, Weilan , SCHMIDT, Maike , HONGO, Jo-Anne , WU, Yan
IPC分类号: C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
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公开(公告)号:EP2152307B1
公开(公告)日:2014-04-16
申请号:EP07783895.1
申请日:2007-05-17
申请人: Genentech, Inc.
IPC分类号: A61K39/395 , A61P35/00 , C07K16/28
CPC分类号: C07K16/2863 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/31 , C07K2317/622 , C07K2317/76 , C07K2317/92
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公开(公告)号:EP2152748B1
公开(公告)日:2013-08-21
申请号:EP08768087.2
申请日:2008-06-03
申请人: Genentech, Inc.
发明人: SIEBEL, Christian, W. , WU, Yan
IPC分类号: C07K16/28 , A61K39/395 , A61P37/00 , A61K35/00 , A61P21/00 , A61P43/00 , C12N15/13 , A61P25/28 , C12N15/73 , C12N1/21
CPC分类号: C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50
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公开(公告)号:EP2411414A1
公开(公告)日:2012-02-01
申请号:EP10722819.9
申请日:2010-03-24
发明人: ASHKENAZI, Avi , QING, Jing , WIESMANN, Christian , WU, Yan
IPC分类号: C07K16/28 , A61K39/395
CPC分类号: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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