公开(公告)号：EP1252918A2

公开(公告)日：2002-10-30

申请号：EP02077399.0

申请日：1993-03-23

申请人： Baxter International Inc.

发明人： Brown, Richard I.

IPC分类号： B01D21/26 ,  A61M1/36 ,  B04B5/04

CPC分类号： B04B13/00 ,  A61M1/0209 ,  A61M1/025 ,  A61M1/029 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/2488 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  A61M2202/0071

摘要： A centrifugal separation apparatus for separating whole blood into red blood cells and a plasma constituent carrying platelets is described. The apparatus comprises a separation chamber (10, 31A, 58) which has first and second spaced apart walls (16, 18, 64, 66) that form a separation zone (84) having a low-G side and a high-G side that is located radially further from the rotational axis than the low-G side. The separation zone includes an entry region (122) where the whole blood enters the separation chamber to begin separation into red blood cells toward the high-G side and the plasma constituent toward the low-G side. Inlet and outlet openings (20, 68, 24, 72) are provided that communicate with the separation chamber. The inlet opening provides for the introduction of whole blood into the entry region. The outlet opening (24, 72) directs the plasma constituent from a plasma constituent collection region (124) at the low-G side of the separation zone adjacent the entry region while whole blood is introduced into the entry region through the inlet opening. The apparatus also comprises an interface control system (134) that is located outside the separation chamber and is arranged to monitor the location of an interface (26) that forms between the red blood cells and the plasma constituent during separation by viewing into the separation zone. A method for centrifugally separating whole blood into red blood cells and a plasma constituent carrying platelets is also described.

摘要翻译： 描述了用于将全血分离成红细胞和携带血小板的血浆成分的离心分离装置。 该设备包括分离室（10,31A，58），该分离室具有形成具有低G侧和高G侧的分离区（84）的第一和第二间隔开的壁（16,18,64,66） 其位于比低G侧更远离旋转轴线的位置。 分离区包括入口区（122），全血进入分离室，开始分离成高-G侧的红细胞和低-G侧的血浆成分。 设置与分离室连通的入口和出口（20,68,24,72）。 入口开口用于将全血引入入口区域。 出口开口（24,72）引导来自等离子体成分收集区域（124）的等离子体成分在邻近入口区域的分离区域的低G侧，同时全血通过入口开口被引入入口区域。 该设备还包括界面控制系统（134），该界面控制系统（134）位于分离室的外部并且被布置成通过观察到分离区域来监测在分离期间在红血细胞和血浆成分之间形成的界面（26）的位置 。 还描述了将全血离心分离成红细胞和携带血小板的血浆成分的方法。

公开(公告)号：EP0775007B1

公开(公告)日：1999-09-29

申请号：EP96916681.8

申请日：1996-05-22

申请人： BAXTER INTERNATIONAL INC.

发明人： BROWN, Richard, I. ,  FOLEY, John, T. ,  ELLIS, Dale, R.

IPC分类号： B01D21/26 ,  A61M1/36 ,  B04B7/08 ,  B04B5/04

CPC分类号： A61M1/0209 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/003 ,  B01D21/0087 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  A61M2202/0071

摘要： A chamber for rotation about a rotational axis to separate blood components includes first and second spaced apart side walls forming a separation zone. Blood conveyed into the separation zone separates into a first region of cellular components, a second region of plasma, and an interface region between the first and second regions. An outlet conveys the second region of plasma from the separation zone. An interior wall extends into the separation zone to permit passage of the second region of plasma to the outlet while retarding passage of the interface region and the first region of cellular components to the outlet. The tapered second surface has a major axis that is oriented at a non-parallel angle with respect to the axis of the outlet. Due to this orientation, the boundary between the interface region and the other two regions is held uniform along the tapered surface. The boundary does not bulge to spill materials in the first interface region or interface region over the first surface and into the constricted passage. As a result, the second region of plasma is kept essentially free of other materials.

公开(公告)号：EP0666770A4

公开(公告)日：1998-08-19

申请号：EP94916495

申请日：1994-02-14

申请人： BAXTER INT

发明人： BROWN RICHARD I

IPC分类号： A61M1/02 ,  A61K35/14 ,  A61M1/36 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  A61M1/00 ,  B04B11/00

CPC分类号： B04B5/0442 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B01D21/262 ,  B01D21/302 ,  B01D2221/08 ,  B01D2221/10 ,  B04B2005/045 ,  A61M2202/0071

摘要： Systems and methods for resuspending cellular-rich concentrates of blood are disclosed. Systems include first compartment (24) including a blood inlet port (40) and a plasma-rich platelets (PRP) collection port (38) and a red blood cell collection port (42), and second compartment (26) including a platelet-poor plasma (PPP) collection port (44) and a leukocyte-depleted PRP (LDPRP) inlet port (46), and a separation element (14). In resuspension mode, a volume of retained PPP is returned through the PPP collection port (44) into the second compartment (26) to mix with and resuspend leukocyte-depleted platelet concentrate (LDPC) in the second compartment (26). During the resuspension period, a rotor (28) slowly oscillates the second compartment (26) first in one rotational direction and then in an opposite rotational direction. The oscillation creates variable agitation forces that aid the mixing and resuspension process within the second compartment (26).

公开(公告)号：EP0856319A3

公开(公告)日：1998-08-12

申请号：EP97122051.2

申请日：1990-09-11

申请人： PALL CORPORATION

发明人： Pall, David B. ,  Gsell, Thomas C. ,  Muellers, Brian T.

IPC分类号： A61M1/02

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M1/3633 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0439 ,  B01D39/1623 ,  A61M2202/0071 ,  A61M2202/005 ,  A61M2202/0057

摘要： A device for processing donated blood comprises a leucocyte-depletion filter interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 75 to about 115 dynes/cm. The filter acts as a leucocyte depletion filter and, in an optional form, as a valve permitting more efficient separation of platelet rich plasma from red blood cell concentrate.

摘要翻译： 用于处理献血的装置包括置于收集袋和卫星袋之间的白细胞消耗过滤器，其中可以表达通过离心分离的成分，过滤器元件优选具有约75至约115达因/厘米的CWST。 该过滤器起到白细胞消耗过滤器的作用，并且以任选形式作为允许从红血细胞浓缩物更有效地分离富含血小板的血浆的阀。

公开(公告)号：EP0643582B1

公开(公告)日：1998-08-12

申请号：EP93913100.9

申请日：1993-06-07

申请人： INOTEB

发明人： DELMAS, Olivier, Marcel, Joseph

IPC分类号： A61K35/14 ,  A61M1/36

CPC分类号： A61M1/0218 ,  A61K35/19 ,  A61M1/3679 ,  A61M2202/0427 ,  A61M2202/005

摘要： Method for preparing platelet factors and device for activation of thrombocytes of human or animal origin. This method for obtaining a solution of platelet factors comprises a step of thrombocyte activation by bringing the thrombocytes in contact with a thrombocyte activating solution, and a solution of platelet factors released by the thrombocytes during the activation stage is collected. The method is characterized in that a liquid containing a suspension of thrombocytes is passed over a filter capable of retaining the thrombocytes, in that an activating solution is added to the thrombocytes retained on the filter, and in that a filtrate containing the platelet factors in solution is separated by filtration, while the thrombocytes remain retained on the filter.

公开(公告)号：EP0856319A2

公开(公告)日：1998-08-05

申请号：EP97122051.2

申请日：1990-09-11

申请人： PALL CORPORATION

发明人： Pall, David B. ,  Gsell, Thomas C. ,  Muellers, Brian T.

IPC分类号： A61M1/02

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M1/3633 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2202/0439 ,  B01D39/1623 ,  A61M2202/0071 ,  A61M2202/005 ,  A61M2202/0057

摘要： A device for processing donated blood comprises a leucocyte-depletion filter interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 75 to about 115 dynes/cm. The filter acts as a leucocyte depletion filter and, in an optional form, as a valve permitting more efficient separation of platelet rich plasma from red blood cell concentrate.

摘要翻译： 一种用于处理对捐献的血液装置包括收集袋和卫星袋在其中通过离心分离的成分可以被过表达之间的白细胞耗尽滤波器，优选具有约75的CWST至约115达因/厘米的过滤器元件。 该滤波器充当去除白细胞过滤器和，在可选的形式中，作为阀允许从红血细胞浓缩物，富含血小板的血浆的更有效的分离。

公开(公告)号：EP0442114B1

公开(公告)日：1998-04-15

申请号：EP90124842.7

申请日：1990-12-20

申请人： Pall Corporation

发明人： Carmen, Raleigh A. ,  Nelson, Edward J.

IPC分类号： A61M1/02

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0071 ,  A61M2202/005

公开(公告)号：EP0755708A3

公开(公告)日：1998-04-01

申请号：EP96202542.5

申请日：1993-03-23

申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)

发明人： Brown, Richard I.

IPC分类号： B01D21/26 ,  B04B5/04 ,  A61M1/36

CPC分类号： B04B13/00 ,  A61M1/0209 ,  A61M1/025 ,  A61M1/029 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/2488 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  A61M2202/0071

摘要： The apparatus includes a chamber (10,31A,58,84) having a first wall (16,64) closer to the rotational axis (14,62) than a second wall (18,66). The first wall (16,64) defines a low-G side of a separation zone and the second wall (18,64) defines a high-G side of the zone. Whole blood enters a zone entry region to separate red cells toward the high-G side and platelet rich plasma (PRP) toward the low-G side. Blood flows through an inlet port (20,68) into the entry region while PRP is collected from the low-G side of the zone in the entry region through an outlet port (24,72). This enhances PRP yields.

摘要翻译： 该设备包括具有比第二壁（18,66）更靠近旋转轴线（14,62）的第一壁（16,64）的腔室（10,31A，58,84）。 第一壁（16,64）限定分离区的低G侧，第二壁（18,64）限定该区的高G侧。 全血进入区域进入区域以将红细胞朝高G侧和富血小板血浆（PRP）分离到低G侧。 血液通过入口端口（20,68）流入入口区域，同时通过出口端口（24,72）从入口区域的区域的低G侧收集PRP。 这提高了PRP产量。

公开(公告)号：EP0749771A3

公开(公告)日：1998-04-01

申请号：EP96202537.5

申请日：1993-03-23

申请人： BAXTER INTERNATIONAL INC.

发明人： Brown, Richard I.

IPC分类号： B01D21/26 ,  B04B5/04 ,  A61M1/36

CPC分类号： B04B13/00 ,  A61M1/0209 ,  A61M1/025 ,  A61M1/029 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/2488 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  A61M2202/0071

摘要： The apparatus includes a chamber (10,31A,58,84) having a first wall (16,64) closer to the rotational axis (14,62) than a second wall (18,66). The first and second walls (16,64;18,66) define respectively low-G and high-G sides of a separation zone. Whole blood enters a zone entry region to separate red cells toward the high-G side and platelet rich plasma (PRP) toward the low-G side. A second region is axially or circumferentially spaced from, and connected to, the entry region by a path conveying blood in a first direction from the entry region to the second region. Blood flows through an inlet port (20,68) into the entry region. PRP is collected from the low-G side of the zone through an outlet port (24,72) opening into the entry region. The first wall (16,64) tapers towards the second wall (18,64) such that the radial distance between the walls decreases in the first flow direction. Platelets of larger than average size are collected.

公开(公告)号：EP0777505A1

公开(公告)日：1997-06-11

申请号：EP96917831.0

申请日：1996-05-22

申请人： BAXTER INTERNATIONAL INC.

发明人： BROWN, Richard, I.

IPC分类号： A61M1

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/0209 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0092

摘要： Systems and methods take into account that the spleen normally holds a number of platelets in reserve out of circulation. During blood procesing, the spleen releases these platelets into the donor's circulatory system, making them available for collection. The systems and methods estimate the number of platelets NSPLEEN held in reserve by the spleen in a human body. The systems and methods derive a splenic mobilization function Spleen, which can be expressed as a function of a precount of platelets PltPRE. The systems and methods estimate NSPLEEN where: NSPLEEN = Spleen-1 x PltPRE x DonVol where DonVol is blood volume in the body. The systems and methods can also estimate the total number of platelets NPLT in a human body, taking the Spleen function into account, where: NPLT = PltPRE x Spleen x DonVol.

摘要翻译： 系统和方法将血小板与选定的供体分开。 系统和方法将含有血浆和血小板的抗凝血从所选供体输送到分离装置中，以分离成血浆产量和血小板产量。 系统和方法至少部分地估计，通过测量选定的供体的血小板计数（Pltpre），估计通过加入抗凝血剂（稀释度）引起的稀释因子，计算可从选定供体收集的血小板（PltCirc）数量 ），并估计在血液处理期间除去可用血小板引起的耗竭因子（耗尽）。 在估计消耗时，系统和方法考虑到脾移动功能（脾），其来源于供体群体，并且不是特定于所选择的供体，其中脾脏包含PltPRE的功能。