公开(公告)号：EP0030682A1

公开(公告)日：1981-06-24

申请号：EP80107597.9

申请日：1980-12-04

申请人： MILES LABORATORIES, INC.

发明人： White, William I.

IPC分类号： G01N33/52 ,  G01N33/72 ,  C07D221/16

CPC分类号： G01N33/725 ,  C12Q1/28 ,  Y10S436/904

摘要： Improved test compositions, devices and methods for the detecting of peroxidatively active substances are provided. The test compositions include an indicator capable of being oxidized in the presence of peroxidatively active substances to provide a color change, an oxidized agent effective to oxidize said indicator, and a sensitizing agent. The sensitizing agent comprises 4-azafluorene.

公开(公告)号：EP2305690B1

公开(公告)日：2012-08-29

申请号：EP10183552.8

申请日：2004-02-17

申请人： LUMIGEN, INC.

发明人： Akhavan-Tafti, Hashem ,  Eickholt, Robert A ,  Lauwers, Kenneth S ,  Handley, Richard S

IPC分类号： C07F5/02 ,  G01N33/533

CPC分类号： C07F5/025 ,  G01N33/533 ,  Y10S436/904 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/206664

公开(公告)号：EP1329721B8

公开(公告)日：2010-05-26

申请号：EP01970262.0

申请日：2001-09-27

申请人： ARKRAY, Inc.

发明人： YONEHARA, Satoshi, c/o ARKRAY, INC. ,  YAGI, Yuji, c/o ARKRAY, INC.

IPC分类号： G01N21/31 ,  G01N21/78 ,  G01N33/72

CPC分类号： G01N33/721 ,  G01N21/31 ,  G01N21/78 ,  G01N33/723 ,  Y10S436/904

公开(公告)号：EP1411356B1

公开(公告)日：2009-03-04

申请号：EP03027486.4

申请日：1992-07-10

申请人： Ischemia Technologies, Inc.

发明人： Bar-Or, David ,  Solomons, Clive

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N21/78 ,  G01N33/52 ,  G01N33/6893 ,  G01N2800/324 ,  Y10S435/81 ,  Y10S436/903 ,  Y10S436/904

公开(公告)号：EP1312918A3

公开(公告)日：2003-11-26

申请号：EP02023497.7

申请日：2002-10-22

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Sumitani, Makoto, Mitsubishi Gas Chemical Co.,Inc. ,  Inoue, Haruo ,  Sugito, Ken, Mitsubishi Gas Chemical Co.,Inc.

IPC分类号： G01N31/22

CPC分类号： G01N31/225 ,  Y10S436/904 ,  Y10T436/10 ,  Y10T436/20 ,  Y10T436/207497 ,  Y10T436/209163

摘要： The oxygen detecting composition of the present invention comprises a layered silicate, a cationic surfactant, an organic colorant, a reducing agent, and optionally a basic substance. The oxygen detecting composition is suitable for indicating the presence or absence of oxygen or the degree of oxygen concentration by its reversible color change because of its high light resistance, high heat resistance, transparency and translucency.

摘要翻译： 本发明的氧检测组合物包含层状硅酸盐，阳离子表面活性剂，有机着色剂，还原剂和任选的碱性物质。 氧检测组合物由于其高耐光性，高耐热性，透明性和半透明性而适合于通过其可逆的颜色变化来指示氧的存在或不存在氧浓度或氧浓度。

公开(公告)号：EP0828159B1

公开(公告)日：2002-07-17

申请号：EP97114435.7

申请日：1997-08-21

申请人： Bayer Corporation

发明人： Pugia, Michael J.

IPC分类号： G01N33/573 ,  G01N33/52

CPC分类号： C12Q1/34 ,  G01N33/68 ,  G01N2333/924 ,  Y10S436/904

公开(公告)号：EP1147131A1

公开(公告)日：2001-10-24

申请号：EP00905749.8

申请日：2000-01-25

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： BUCHANAN, Bob, B. ,  DEL VAL, Gregorio ,  LOZANO, Rosa, M. ,  WONG, Joshua, H. ,  YEE, Boihon, C. ,  FRICK, Oscar, L.

IPC分类号： C07K14/415 ,  A61K38/00 ,  A61P37/00

CPC分类号： A21D2/26 ,  A21D2/264 ,  A21D2/265 ,  A21D2/266 ,  A21D2/36 ,  A21D8/04 ,  A21D13/064 ,  A23C9/1209 ,  A23C9/1213 ,  A23C9/152 ,  A23J1/12 ,  A23J1/14 ,  A23J3/08 ,  A23J3/18 ,  A23K20/147 ,  A23L5/27 ,  A23L7/109 ,  A23L11/34 ,  A23L13/48 ,  A23L33/17 ,  A61K39/35 ,  A61K2035/122 ,  C07K1/1133 ,  C07K14/415 ,  C07K14/43504 ,  C07K14/46 ,  C07K14/76 ,  C07K14/811 ,  C12N9/0036 ,  C12N9/20 ,  C12P21/02 ,  C12Q1/26 ,  C12Q1/34 ,  C12Y108/01008 ,  C12Y108/01009 ,  Y10S436/904 ,  Y10T436/182

摘要： Thioredoxin, a small dithiol protein, is a specific reductant for allergenic proteins and particularly allergenic proteins present in pollen and animal and plant sources. All targeted proteins contain disulfide (S-S) bonds that are reduced to the sulfhydryl (SH) level by thioredoxin. The proteins are allergenically active and less digestible in the oxidized (S-S) state. When reduced (SH state), they lose their allergenicity and/or become more digestible. Thioredoxin achieved this reduction when activated (reduced) either by NADPH via NADP-thioredoxin reductase (physiological conditions) or by lipoic acid chemical reductant. Skin tests carried out with sensitized dogs showed that treatment of the pollens with reduced thioredoxin prior to injection eliminated or decreased the allergenicity of the pollen. Studies showed increased digestion of the pollen proteins by pepsin following reduction by thioredoxin. Pollen proteins that have been reduced by thioredoxin are effective and safe immunotherapeutic agents for decreasing or eliminating an animal's allergic reaction that would otherwise occur upon exposure to the non-reduced pollen protein.

公开(公告)号：EP0992795A1

公开(公告)日：2000-04-12

申请号：EP99117955.7

申请日：1999-09-15

申请人： Bayer Corporation

发明人： Cast, Todd K. ,  Pugia, Michael J.

IPC分类号： G01N33/70

CPC分类号： G01N33/70 ,  Y10S436/904 ,  Y10T436/147777 ,  Y10T436/17

摘要： Disclosed is an improvement to the assay for creatinine in fluid test samples by contacting the test sample with a reagent formulation containing cupric ions, a hydroperoxide and an oxidizable dye. The improvement involves the inclusion of one or more selected quinolines in the reagent formulation. When the quinoline is substituted with methyl in the 2-5 position and/or a methoxy in the 2-6 position autooxidation of the oxidizable dye is reduced. When the quinoline is further substituted in an otherwise unsubstituted carbon atom in the 2-8 position, the assay's resistance to interference from hemoglobin and ascorbate is increased.

公开(公告)号：EP0756704B1

公开(公告)日：1999-06-16

申请号：EP95915508.6

申请日：1995-04-03

申请人： Cryovac, Inc.

发明人： BLINKA, Thomas, Andrew ,  BULL, Christopher ,  BARMORE, Charles, Rice ,  SPEER, Drew, Ve

IPC分类号： G01N15/08 ,  G01N31/22

CPC分类号： G01N31/225 ,  G01N15/08 ,  Y10S436/904 ,  Y10T436/20 ,  Y10T436/209163

摘要： A method of detecting the permeability of an article to oxygen is disclosed. A fluorescent redox indicator, preferably riboflavin, is dispersed in a carrier and placed on an impermeable substrate. The article to be measured is placed adjacent to the carrier. Residual oxygen is removed, the redox indicator is photoreduced, the article and carrier are exposed to oxygen, and the indicator is exposed to UV light.

公开(公告)号：EP0463171B1

公开(公告)日：1996-04-17

申请号：EP91900927.4

申请日：1990-12-19

申请人： IATRON LABORATORIES, INC.

发明人： HAMA, Michio, c/o Iatron Labor. Inc. ,  NAKAYAMA, Michiyo, c/o Iatron Labor. Inc. ,  TANAKA, Mitsunao, c/o Iatron Labor. Inc.

IPC分类号： G01N33/66 ,  C12Q1/28

CPC分类号： C12Q1/28 ,  G01N33/66 ,  Y10S436/904 ,  Y10T436/144444

摘要： A method of determining fructosamine, which comprises the steps of : (a) bringing an aqueous liquid specimen into contact with an active oxygen generating substance, (b) bringing a reagent which causes a detectable change in the presence of hydrogen peroxide derived from active oxygen into contact with the product of step (a), and (c) detecting the detectable change caused in step (b).