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    Production method for optically active N-aryl-beta-amino acid compounds
    41.
    发明公开
    Production method for optically active N-aryl-beta-amino acid compounds 审中-公开
    产品 - Verfahrenfüroptisch-aktive N-Aryl-beta-aminosäureVerbindungen

    公开(公告)号：EP1471050A1

    公开(公告)日：2004-10-27

    申请号：EP04252345.6

    申请日：2004-04-21

    申请人： Ajinomoto Co., Inc.

    发明人： Hamada, Takayuki ,  Izawa, Kunisuke

    IPC分类号： C07C227/32 ,  C07C229/18 ,  C07C303/28

    CPC分类号： C07C227/32 ,  C07B2200/07 ,  C07C229/18

    摘要： In a method suitable for industrial application, an optically active N-aryl-β-amino acid compound is produced by the reaction of an aromatic amine and an optically active sulfonylated β-hydroxycarboxylic acid compound. The latter can be easily derived from a β-keto carboxylic acid compound.

    摘要翻译： 光学活性N-芳基-β-氨基酸化合物（III）的制备涉及光学活性磺酰化的β-羟基羧酸化合物和芳族胺的反应。 制备式YC * H（NH-X）-CH 2 -C（O）-Z（III）的光学活性N-芳基-β-氨基酸化合物包括使式YC的光学活性磺酰化β-羟基羧酸化合物 * H（OSO 2 R 1）-CH 2 -C（O）-Z（I）和式X-NH 2（II）的芳族胺。 Y：任选取代的甲基或芳基; Z：氨基，烷氧基或芳氧基（全部被取代）或OH; R11-10C烷基，6-15C芳基或7-20C芳烷基（全部被取代）; C *：具有R或S构型的光学活性C; 和X：6-15C芳基或3-15C杂芳族（均可任意取代）。

    N-substituted anilines
    46.
    发明公开
    N-substituted anilines 失效
    N-取代的苯胺

    公开(公告)号：EP0579066A3

    公开(公告)日：1996-01-03

    申请号：EP93110665.2

    申请日：1993-07-03

    申请人： F. HOFFMANN-LA ROCHE AG

    发明人： Carson, Mathew ,  Han, Ru-Jen Lee ,  LeMahieu, Ronald Andrew ,  Madison, Vincent Stewart

    IPC分类号： C07C229/18 ,  C07C237/30 ,  C07C275/40 ,  C07C229/60 ,  C07C229/62 ,  C07C271/44 ,  C07C323/35 ,  C07C317/16 ,  C07C317/22 ,  C07D213/65 ,  C07D215/22

    CPC分类号： C07C323/36 ,  C07C229/18 ,  C07C229/60 ,  C07C229/64 ,  C07C233/43 ,  C07C237/30 ,  C07C237/38 ,  C07C271/44 ,  C07C311/09 ,  C07C317/22 ,  C07C317/36 ,  C07C317/44 ,  C07C2603/74 ,  C07F9/4006

    摘要： 57 Compounds of the formula

    wherein
    R 1 is hydrogen or -(CH 2 ) m COOR 2 ; R 2 is hydrogen, (R 6 ) 2 N(CH 2 ) 2 -, R 6 COOCH 2 - or -CH 2 CON(CH 2 CH 2 0H) 2 ; R 3 is hydrogen, nitro, hydroxy, amino, CH 3 (CH 2 ) n S(O) 0-2 -, CH 3 (CH 2 ) n -,CH 3 (CH 2 ) n O- ,R 5 COO-, RsOOC- ,R 5 HNCOO-, RsNHCO-, RsCONH-, RsNHCONH-, [CH 3 (CH 2 ) n]2 NCO- , CH 3 (CH 2 ) n CHOHCH 2 0-, (2-quinolinyl)methoxy, oleyloxy, linoleyloxy, R 8 OOC(CH 2 ) t -O, (R 6 0) 2 PO(CH 2 )pO- , (HO) (R 6 0)PO(CH 2 )pO- , R 6 [O(CH 2 ) 2 ] q O- , R 7 (CH 2 )pO-, or -O(CH 2 ) p -pyridinium + (OH - ); R 4 is CH 3 (CH 2 ) n - , CH 3 (CH 2 ) n O- , CF 3 SO 2 NH-, RsCOO-, RsOOC- ,R 5 HNCOO-, RsNHCO-, RsCONH-RsNHCONH-, [CH 3 (CH 2 ) n]2 NCO-, CH 3 (CH 2 ) n CHOHCH 2 0-, carboxy, (2-quinolinyl)methoxy, oleyloxy, linoleyloxy, R 8 OOC(CH 2 ) t O-, R 6 [O(CH 2 ) 2 ] q O- , or R 7 (CH 2 )pO-; R 5 is CH 3 (CH 2 ) n -, 1-adamantyl or diphenylmethyl; R 6 is lower alkyl; R 7 is 1- or 2 -naphthyloxy, 1-, 2- or 3-pyridinyloxy, 2,3- or 3,4-dihydroxyphenyl, 6,7-dihydroxy-2-naphthyl, phenyl, phenoxy or substituted phenyl or phenoxy, wherein the substituent is selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, nitro, amino, halo, R 6 S(O) 0-2 -, carboxy, carboxy-lower alkyl or phenyl; R 8 is hydrogen or lower alkyl; n is an integer from 0 to 17; m is an integer from 1 to 3; t is an integer from 1 to 10; p is an integer from 2 to 18, and q is an integer from 1 to 6;
    and when R 2 is hydrogen, a pharmaceutically acceptable salt thereof with a base, are potent inhibitors of phospholipases A 2 (PLA 2 's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury.

    摘要翻译： 式CHEM的化合物，其中R 1是氢或 - （CH 2）m COOR 2; R2是氢，（R6）2N（CH2）2-，R6COOCH2-或-CH2CON（CH2CH2OH）2; R3是氢，硝基，羟基，氨基，CH3（CH2）nS（O）0-2-，CH3（CH2）n-，CH3（CH2）nO-，R5COO-，R5OOC-，R5HNCOO-，R5NHCO-，R5CONH - ，R5NHCONH-，[CH3（CH2）n] 2NCO-，CH3（CH2）nCHOHCH2O-，（2-喹啉基）甲氧基，油酰氧基，亚油酰氧基，R8OOC（CH2）tO-，（R6O）2PO（CH2） （HO）（R6O）PO（CH2）pO-，R6 [O（CH2）2] qO-，R7（CH2）pO-或-O（CH2）p-吡啶鎓+（OH） R4是CH3（CH2）n-，CH3（CH2）nO-，CF3SO2NH-，R5COO-，R5OOC-，R5HNCOO-，R5NHCO-，R5CONH-R5NHCONH-，[CH3（CH2）n] 2NCO-，CH3 （CH 2）t O - ，R 6（O（CH 2）2] q O - 或R 7（CH 2）p O - ; R5是CH3（CH2）n-，1-金刚烷基或二苯基甲基; R6是低级烷基; R 7是1-或2-萘氧基，1-，2-或3-吡啶氧基，2,3-或3,4-二羟基苯基，6,7-二羟基-2-萘基，苯基，苯氧基或取代的苯基或苯氧基，其中 取代基选自低级烷基，低级烷氧基，羟基，硝基，氨基，卤素，R 6 S（O）0-2-，羧基，羧基 - 低级烷基或苯基; R8是氢或低级烷基; n为0〜17的整数。 m为1〜3的整数; t是1至10的整数; p为2〜18的整数，q为1〜6的整数。 当R2为氢时，其药学上可接受的盐与碱形成磷酸酶A2（PLA2's）的有效抑制剂，因此可用于治疗炎性疾病，如精神病，炎性肠病，哮喘，变态反应，关节炎，皮炎 ，痛风，肺部疾病，心肌缺血/再灌注和创伤引起的炎症，如脊髓损伤。

    CHELATING AGENTS FOR TREATING NUTRITIONAL DISORDERS OF PLANTS
    49.
    发明公开
    CHELATING AGENTS FOR TREATING NUTRITIONAL DISORDERS OF PLANTS 审中-公开

    公开(公告)号：EP3406590A1

    公开(公告)日：2018-11-28

    申请号：EP18174421.0

    申请日：2018-05-25

    申请人： Valagro S.p.A.

    发明人： BIASONE, Alessandro

    IPC分类号： C07C229/18 ,  C05D9/02 ,  C07C229/36 ,  C07C229/76

    CPC分类号： C07C229/36 ,  C05D9/02 ,  C07C229/14 ,  C07C229/76

    摘要： The present disclosure relates to a compound of general formula (I):

    wherein R1 and R4 are independently selected from H and COOH, R2 and R3 are independently selected from H and (CH 2 ) m COOH, in which m = 1, 2 or 3, and n is equal to 2 or 3.
    The present disclosure also relates to a chelate compound, which is a complex of the compound of formula (I) with a metal ion selected from the group consisting of Fe, Cu, Mg, Ca, Mn and Zn.
    The invention regards also the use of the compounds of formula (I) and/or their chelate complex for treating and/or preventing nutritional disorders of plants, in particular for treating and/or preventing iron chlorosis of plants.