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173 条记录 (耗时 0.041 秒)

    PROCESSES OF SYNTHESIZING DIHYDROPYRIDOPHTHALAZINONE DERIVATIVES
    51.
    发明公开
    PROCESSES OF SYNTHESIZING DIHYDROPYRIDOPHTHALAZINONE DERIVATIVES 有权
    合成二氢吡啶并哒嗪酮衍生物的过程

    公开(公告)号：EP2533640A1

    公开(公告)日：2012-12-19

    申请号：EP11740513.4

    申请日：2011-02-08

    申请人： BioMarin Pharmaceutical Inc.

    发明人： WANG, Bing ,  CHU, Daniel ,  LIU, Yongbo ,  JIANG, Quan ,  LU, Lei

    IPC分类号： A01N43/58

    CPC分类号： C07D405/06 ,  C07D249/08 ,  C07D401/04 ,  C07D403/06 ,  C07D471/06

    摘要： Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.

    摘要翻译： 本文提供了合成二氢吡啶并二氮杂萘酮衍生物的方法，例如5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8 ，9-二氢-2H-吡啶并[4,3,2-de]酞嗪-3（7H） - 酮及其立体异构体，其是有效的聚（ADP-核糖）聚合酶（PARP）抑制剂以及新的合成 中间化合物。

    METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASE
    59.
    发明公开
    METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASE 审中-公开
    方法和组合物疾病治疗

    公开(公告)号：EP1965803A1

    公开(公告)日：2008-09-10

    申请号：EP06839043.4

    申请日：2006-12-05

    申请人： Biomarin Pharmaceutical Inc.

    发明人： OPPENHEIMER, Daniel, I. ,  KAKKIS, Emil, D. ,  DORENBAUM, Alejandro

    IPC分类号： A61K31/519 ,  A61P9/10 ,  A61P9/12

    CPC分类号： A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention is directed to a novel methods and compositions for the therapeutic intervention of vascular complications associated with diabetes, hyperlipidemias, and various cardiovascular disorders including but not limited to recalcitrant hypertension, coronary artery disease, pulmonary arterial hypertension, congestive heart failure, and hemolytic anemias. More specifically, the specification describes methods and compositions for treating such vascular disorders using compositions comprising BH4 and derivative thereof. Combination therapies of BH4 and other therapeutic regimens are contemplated.

    ROOM TEMPERATURE STABLE AQUEOUS LIQUID PHARMACEUTICAL COMPOSITION
    60.
    发明公开
    ROOM TEMPERATURE STABLE AQUEOUS LIQUID PHARMACEUTICAL COMPOSITION 审中-公开
    在室温下稳定的水性药物液体组成

    公开(公告)号：EP1850854A1

    公开(公告)日：2007-11-07

    申请号：EP05724171.3

    申请日：2005-02-25

    申请人： Biomarin Pharmaceutical Inc.

    发明人： MEDICIS PEDIATRICS, INC. ,  CLEMENTE, Emmett ,  PATEL, Bhiku ,  BHATIA, Kuljit ,  SORGI, Frank, L. ,  KAKKIS, Emil, D.

    IPC分类号： A61K31/545

    CPC分类号： A61K9/0095 ,  A61K47/26

    摘要： A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a drug dissolved or dispersed in an aqueous medium. The aqueous medium consists essentially of water, about 3% to about 10% w/v polyvinylpyrrolidone, about 60% to about 75% w/v of C3-C6 polyol that includes more than 55% w/v of a non-reducing disaccharide, trisaccharide or tetrasaccharide such as sucrose, optionally about 0.0 1% to about 0.5% w/v of a glycyrrhetic acid, glycyrrhizinate derivative or salt thereof, and one or more flavorants, and preferably includes one or more preservatives. The liquid composition is room temperature stable, and may have a pleasant taste.