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    HAEMOPOIETIC GROWTH FACTOR ANTAGONISTS
    55.
    发明公开
    HAEMOPOIETIC GROWTH FACTOR ANTAGONISTS 失效
    的粒细胞 - 巨噬细胞集落刺激因子的拮抗剂（GM-CSF）

    公开(公告)号：EP0715633A1

    公开(公告)日：1996-06-12

    申请号：EP94922181.0

    申请日：1994-07-28

    申请人： MEDVET SCIENCE PTY. LTD.

    发明人： VADAS, Mathew Alexander ,  LOPEZ, Angel Francisco ,  SHANNON, Mary Frances

    IPC分类号： C12N15 ,  A61K38 ,  A61P7 ,  C07K14 ,  C12N1 ,  C12P21 ,  C12R1

    CPC分类号： C07K14/505 ,  A61K38/00 ,  C07K14/535 ,  C07K14/54

    摘要： The present invention relates to modified and variant forms of haemopoietic growth factors (HGF) capable of acting as antagonists to the corresponding native haemopoietic growth factors and their use in ameliorating aberrant effects caused by the native molecules. A modified haemopoietic growth factor (HGF) is characterized by being in unglycosylated form and comprising a sequence of amino acids within a first α-helix wherein one or more exposed amino acids in said first α-helix having acidic or acidic-like properties are substituted with a basic amino acid residue. The preferred HGF are granulocyte-macrophage colony-stimulating factor (GM-CSF), interleuking (IL)-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, G-CSF and erythropoietin (EPO).

    METHOD AND APPARATUS FOR DETECTING THE ONSET OF HYPOGLYCAEMIA
    58.
    发明公开
    METHOD AND APPARATUS FOR DETECTING THE ONSET OF HYPOGLYCAEMIA 审中-公开
    方法和一种用于检测低血糖的开始

    公开(公告)号：EP2790579A4

    公开(公告)日：2015-10-07

    申请号：EP12856995

    申请日：2012-12-12

    申请人： MEDVET SCIENCE PTY LTD

    发明人： BURNET RICHARD BRUCE

    IPC分类号： A61B5/11 ,  A61B5/00 ,  A61B5/145

    CPC分类号： A61B5/1101 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/6801 ,  A61B5/6824 ,  A61B5/7257 ,  A61B5/7282 ,  A61B5/746 ,  A61B2562/0219

    摘要： A method and apparatus for the detection of the onset of hypoglycaemia is described. A portable sensor worn by a subject is used to detect a physiological tremor signal. The tremor signal is analysed over a period of time, and an alarm is generated when a change in the physiological tremor signal indicative of the onset of hypoglycaemia in the subject is detected. A patient or carer can then perform appropriate action, such as performing a finger prick test to determine blood sugar test and treating as required. The portable sensor can be used to detect a tremor signal indicative of the, the onset of hypoglycaemia such as a signal corresponding to a decrease in blood glucose level (BGL) below 5 mmol/l. The portable sensor can use an accelerometer and may be worn on a limb, such as an arm or leg. The sensor can be used to measure the power of the tremor signal and detect a change, such as an increase in power over time and/or an increase in the rate of change of power over time. Filtering the signal may include filtering signals outside of the range 0-50 Hz, or more specifically 7-15 Hz.

    SCREENING METHOD
    59.
    发明公开
    SCREENING METHOD 审中-公开
    筛选过程

    公开(公告)号：EP2758778A4

    公开(公告)日：2015-06-03

    申请号：EP12833527

    申请日：2012-09-21

    申请人： MEDVET SCIENCE PTY LTD

    发明人： SCHWARZ QUENTEN PHILIP ,  LOPEZ ANGEL FRANCISCO

    IPC分类号： G01N33/50 ,  C12N15/12 ,  G01N33/68

    CPC分类号： C12Q1/6883 ,  C07K14/4705 ,  G01N33/5088 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/4706 ,  G01N2500/00 ,  G01N2800/30 ,  G01N2800/302 ,  G01N2800/50 ,  G01N2800/52

    摘要： The present invention provides a method of screening a mammal for the onset or predisposition to the onset of a neuropsychiatric disorder. More particularly, the present invention provides a method of screening a mammal for the onset or predisposition to the onset of schizophrenia by screening for a decrease in the functional level of protein 14-3-3ζ. In a related aspect, the present invention also provides a means of monitoring a patient diagnosed with a neuropsychiatric disorder, such as schizophrenia, by screening for changes to functional levels of protein 14-3-3ζ. This may be useful, for example, in the context of evaluating the effectiveness of a prophylactic or therapeutic treatment regime or otherwise monitoring the impact of physiological or metabolic changes which may occur in a patient. The method of the present invention is useful in a wide range of applications including, inter alia, providing a means of identifying mammals susceptible to the onset of a neuropsychiatric condition, such as a condition characterized by one or more symptoms of schizophrenia, thereby enabling the implementation of prophylactic or early therapeutic intervention in an effort to either minimize or prevent the onset of the condition. It also provides a means of confirming diagnoses which would otherwise be based solely on an assessment of positive and negative symptoms.

    METHOD AND APPARATUS FOR DETECTING THE ONSET OF HYPOGLYCAEMIA
    60.
    发明公开
    METHOD AND APPARATUS FOR DETECTING THE ONSET OF HYPOGLYCAEMIA 审中-公开
    方法和一种用于检测低血糖的开始

    公开(公告)号：EP2790579A1

    公开(公告)日：2014-10-22

    申请号：EP12856995.1

    申请日：2012-12-12

    申请人： Medvet Science Pty Ltd

    发明人： BURNET, Richard Bruce

    IPC分类号： A61B5/11 ,  A61B5/145

    CPC分类号： A61B5/1101 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/6801 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/6825 ,  A61B5/7257 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  A61B2562/0219

    摘要： A method and apparatus for the detection of the onset of hypoglycaemia is described. A portable sensor worn by a subject is used to detect a physiological tremor signal. The tremor signal is analysed over a period of time, and an alarm is generated when a change in the physiological tremor signal indicative of the onset of hypoglycaemia in the subject is detected. A patient or carer can then perform appropriate action, such as performing a finger prick test to determine blood sugar test and treating as required. The portable sensor can be used to detect a tremor signal indicative of the, the onset of hypoglycaemia such as a signal corresponding to a decrease in blood glucose level (BGL) below 5 mmol/l. The portable sensor can use an accelerometer and may be worn on a limb, such as an arm or leg. The sensor can be used to measure the power of the tremor signal and detect a change, such as an increase in power over time and/or an increase in the rate of change of power over time. Filtering the signal may include filtering signals outside of the range 0-50 Hz, or more specifically 7-15 Hz.