公开(公告)号：EP1527038B1

公开(公告)日：2010-03-17

申请号：EP03784245.7

申请日：2003-08-04

申请人： Lucite International UK Limited

发明人： EASTHAM, Graham, Ronald ,  JIMENEZ, Cristina ,  COLE-HAMILTON, David

IPC分类号： C07C51/14 ,  C07C67/38 ,  C07C69/24

CPC分类号： B01J31/1895 ,  B01J31/1616 ,  B01J31/165 ,  B01J31/24 ,  B01J31/2409 ,  B01J31/2452 ,  B01J31/2457 ,  B01J35/0013 ,  B01J2231/321 ,  B01J2531/0258 ,  B01J2531/80 ,  B01J2531/824 ,  C07C67/38 ,  C07C2603/74 ,  C07F9/5018 ,  C07F9/5027 ,  C07F9/5045 ,  C07F9/52 ,  C07C69/24

摘要： A process for the carbonylation of ethylenically unsaturated compounds is described. The process comprises reacting an ethylenically unsaturated compound with carbon monoxide in the presence of a source of hydroxyl groups and a catalyst system. The catalyst system is obtained by combining: (a) metal of Group VIII or a compound thereof: and (b) a bidentate phosphine of general formula (I) The carbonylation reaction is carried out at a temperature of between -30°C to 49°C and under a CO partial pressure of less than 30 x105 N.m-2.

公开(公告)号：EP1534427B1

公开(公告)日：2009-10-21

申请号：EP03784257.2

申请日：2003-08-06

申请人： Lucite International UK Limited

发明人： EASTHAM, Graham, Ronald ,  CAMERON, Paul, Andrew ,  TOOZE, Robert, Paul ,  CAVELL, Kingsley, John ,  EDWARDS, Peter, Gerald ,  COLEMAN, Dennis, Lee

IPC分类号： B01J31/24 ,  B01J35/00 ,  C07F9/6564 ,  C07C67/38

CPC分类号： B01J31/1895 ,  B01J31/2457 ,  B01J35/0013 ,  B01J2231/321 ,  B01J2531/0258 ,  B01J2531/60 ,  B01J2531/80 ,  B01J2531/824 ,  C07C67/38 ,  C07C2603/74 ,  C07F9/5018 ,  C07F9/5027 ,  C07F9/5045 ,  C07F9/52 ,  C07C69/24 ,  C07C69/67

摘要： A catalyst system capable of catalysing the carbonylation of an olefinally unsaturated compound is described. The 5 catalyst system is obtainable by combining: (a) a metal of Group VIB or Group VIII B or a compound thereof; and (b) a bidentate phosphine of general formula (I) Ad) s (CR4R5R6) T Q2-A- (K, D) Ar (E, Z) -B-Q1 (Ad) u (CR1R2R3) v. Ad represents an optionally substituted adamantyl radical bonded to the phosphorous atom via any one of its tertiary carbon atoms. A method of production of the catalyst is also illustrated.

摘要翻译： 描述了能够催化烯属不饱和化合物的羰基化的催化剂体系。 5催化剂体系可通过以下方法获得：（a）VIB族或VIIIB族金属或其化合物; 和（b）通式（I）的二齿膦Ad））_{Ť Q ^{2 -A-（K，D）中的Ar（E，Z）-bq 1 （AD）û （CR 1 - [R 2 - [R 3 ） v 。 Ad表示任意取代的金刚烷基，其通过其叔碳原子中的任何一个与磷原子键合。 还示出了催化剂的生产方法。}}

公开(公告)号：EP1470136B1

公开(公告)日：2007-03-28

申请号：EP03704443.5

申请日：2003-01-21

申请人： BASF Aktiengesellschaft

发明人： VOLLAND, Martin ,  SEITZ, Verena ,  MAASE, Matthias ,  FLORES, Miguel Angel ,  PAPP, Rainer ,  MASSONNE, Klemens ,  STEGMANN, Veit ,  HALBRITTER, Klaus ,  NOE, Ralf ,  BARTSCH, Michael ,  SIEGEL, Wolfgang ,  BECKER, Michael ,  HUTTENLOCH, Oliver

IPC分类号： C07F9/22 ,  C07B63/00

CPC分类号： C07C403/12 ,  C07C1/30 ,  C07C45/50 ,  C07C51/412 ,  C07C51/58 ,  C07C67/14 ,  C07C2531/02 ,  C07C2601/16 ,  C07D295/185 ,  C07D317/36 ,  C07F9/142 ,  C07F9/145 ,  C07F9/46 ,  C07F9/4841 ,  C07F9/52 ,  C07F9/5721 ,  C07F9/5728 ,  C07F9/65038 ,  C07F9/65746 ,  C07F9/65848 ,  C07C47/02 ,  C07C13/23 ,  C07C69/78 ,  C07C69/24 ,  C07C69/14 ,  C07C53/10

摘要： Disclosed is a method for producing aminodihalophosphines, diaminohalophosphines, triaminophosphines, phosphite diamides, aminophosphines, diaminophosphines, phosphite amide halogenides, and aminophosphine halogenides by separating an acid in the presence of an auxiliary base. Said auxiliary base b) forms a salt with an acid, which is liquid at temperatures at which the valuable product is not significantly decomposed during separation of the liquid salt, and c) the salt of the auxiliary base and the valuable product or the solution of the valuable product form two immiscible phases in a suitable solvent.

摘要翻译： 一种用于使用辅助碱的除去从反应混合物中的酸处理，其中，所述辅助碱：与酸结合形成盐的所有其处的，其值的产品不除去液体盐的过程中显着分解温度下为液体， 与有价值的产物或值在合适的溶剂中的产物的溶液中的辅助碱的盐形成两个不混溶的液相。

公开(公告)号：EP1355912B1

公开(公告)日：2006-02-22

申请号：EP02732152.0

申请日：2002-01-18

申请人： Chirotech Technology Limited

发明人： ZANOTTI-GEROSA, Antonio, Chirotech Technology Ltd ,  MALAN, Christophe, Guillaume ,  HENSCHKE, Julian, Paul, Chirotech Technology Ltd ,  HERZBERG, Daniela, Chirotech Technology Ltd

IPC分类号： C07F9/48 ,  C07F9/52 ,  C07F9/50 ,  C07F9/6571 ,  C07F9/6584 ,  C07F9/6568 ,  C07F15/00 ,  C07B53/00 ,  C07C45/50

CPC分类号： C07B53/00 ,  C07C45/505 ,  C07C209/52 ,  C07C231/18 ,  C07C2603/92 ,  C07F9/485 ,  C07F9/4883 ,  C07F9/5027 ,  C07F9/52 ,  C07F9/65683 ,  C07F9/65719 ,  C07F9/65844 ,  C07F9/65848 ,  C07F15/0033 ,  C07F15/0073 ,  C07C211/45 ,  C07C233/36

摘要： A compound of general formula 4 wherein each of W, X, Y and Z is any substituent where a heteroatom is bonded to phosphorus, optionally linked in pairs X/Y and Z/W to form a ring, or W=X=Y=Z=H, is new. Complexes thereof can be used in asymmetric reactions such as hydrogenation.

公开(公告)号：EP1565425A1

公开(公告)日：2005-08-24

申请号：EP03769682.0

申请日：2003-10-31

申请人： Lucite International UK Limited

发明人： EASTHAM, Graham Ronald ,  RUCKLIDGE, Adam, John ,  COLE-HAMILTON, David

IPC分类号： C07C67/347 ,  C07C67/31 ,  C07C69/716 ,  C07C69/68

CPC分类号： B01J31/2457 ,  B01J31/1616 ,  B01J31/165 ,  B01J31/1895 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2409 ,  B01J35/0013 ,  B01J2231/321 ,  B01J2531/0205 ,  B01J2531/0258 ,  B01J2531/80 ,  B01J2531/824 ,  B01J2531/842 ,  C07C51/09 ,  C07C67/03 ,  C07C67/30 ,  C07C67/31 ,  C07C67/38 ,  C07C2603/74 ,  C07F9/5018 ,  C07F9/5027 ,  C07F9/5045 ,  C07F9/52 ,  C07C69/675 ,  C07C69/67 ,  C07C59/08 ,  C07C59/01 ,  C07C69/68

摘要： The present invention relates to the carbonylation of an ester, specifically vinyl acetate. The process comprises the carbonylation of vinyl acetate comprising reacting vinyl acetate with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system, the catalyst system obtainable by combining: (c) a metal of Group VIII B or a compound thereof: and (d) a bidentate phosphine of general formula (I). A process for the production of a lactate ester or acid of formula (II), comprising the steps of carbonylating vinyl acetate with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system is also described. A process for the production of 3-hydroxy propanoate ester or acid of formula (III) comprising the steps of: carbonylating vinyl acetate with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system also forms an aspect of the invention.

公开(公告)号：EP1558384A1

公开(公告)日：2005-08-03

申请号：EP03750375.2

申请日：2003-09-26

申请人： Studiengesellschaft Kohle mbH

发明人： REETZ, Manfred, T. ,  SELL, Thorsten ,  MEISWINKEL, Andreas ,  MEHLER, Gerlinde

IPC分类号： B01J31/18 ,  B01J23/46 ,  C07F9/50 ,  C07F15/00 ,  C07F19/00 ,  C07F9/6571 ,  B01J31/24 ,  C07B53/00

CPC分类号： B01J31/185 ,  B01J23/464 ,  B01J31/1845 ,  B01J31/1855 ,  B01J31/1865 ,  B01J31/187 ,  B01J31/24 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/321 ,  B01J2231/323 ,  B01J2231/325 ,  B01J2231/326 ,  B01J2231/327 ,  B01J2231/342 ,  B01J2231/348 ,  B01J2231/4211 ,  B01J2231/4238 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/641 ,  B01J2231/72 ,  B01J2531/0266 ,  B01J2531/80 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07B53/00 ,  C07C67/303 ,  C07C231/12 ,  C07F9/46 ,  C07F9/5022 ,  C07F9/52 ,  C07F9/6568 ,  C07F9/65683 ,  C07F9/65742 ,  C07F9/65744 ,  C07F9/65842 ,  C07F9/65844 ,  C07F9/65848 ,  Y10S502/506 ,  C07C69/34 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18

摘要： The invention relates to certain chiral transition metal catalysts, to the metal of which at least two structurally different monophosphorus ligands are bonded, at least one of said monophosphorus ligands being chiral. Said chiral transition metal catalysts are suitable as catalysts for use in asymmetric transition metal-catalyzed reactions, providing better enantioselectivities than in cases where only one structurally defined ligand is used.

公开(公告)号：EP1534427A1

公开(公告)日：2005-06-01

申请号：EP03784257.2

申请日：2003-08-06

申请人： Lucite International UK Limited

发明人： EASTHAM, Graham, Ronald ,  CAMERON, Paul, Andrew ,  TOOZE, Robert, Paul ,  CAVELL, Kingsley, John ,  EDWARDS, Peter, Gerald ,  COLEMAN, Dennis, Lee

IPC分类号： B01J31/24 ,  B01J35/00 ,  C07F9/6564 ,  C07C67/38

CPC分类号： B01J31/1895 ,  B01J31/2457 ,  B01J35/0013 ,  B01J2231/321 ,  B01J2531/0258 ,  B01J2531/60 ,  B01J2531/80 ,  B01J2531/824 ,  C07C67/38 ,  C07C2603/74 ,  C07F9/5018 ,  C07F9/5027 ,  C07F9/5045 ,  C07F9/52 ,  C07C69/24 ,  C07C69/67

摘要： A catalyst system capable of catalysing the carbonylation of an olefinally unsaturated compound is described. The 5 catalyst system is obtainable by combining: (a) a metal of Group VIB or Group VIII B or a compound thereof; and (b) a bidentate phosphine of general formula (I) Ad) s (CR4R5R6) T Q2-A- (K, D) Ar (E, Z) -B-Q1 (Ad) u (CR1R2R3) v. Ad represents an optionally substituted adamantyl radical bonded to the phosphorous atom via any one of its tertiary carbon atoms. A method of production of the catalyst is also illustrated.

公开(公告)号：EP1472201A2

公开(公告)日：2004-11-03

申请号：EP03702479.1

申请日：2003-01-21

申请人： BASF AKTIENGESELLSCHAFT

发明人： MAASE, Matthias ,  MASSONNE, Klemens ,  HALBRITTER, Klaus ,  NOE, Ralf ,  BARTSCH, Michael ,  SIEGEL, Wolfgang ,  STEGMANN, Veit ,  FLORES, Miguel ,  HUTTENLOCH, Oliver ,  BECKER, Michael

IPC分类号： C07B63/00 ,  C07F9/02

CPC分类号： C07C403/12 ,  C07C1/30 ,  C07C45/50 ,  C07C51/412 ,  C07C51/58 ,  C07C67/14 ,  C07C2531/02 ,  C07C2601/16 ,  C07D295/185 ,  C07D317/36 ,  C07F9/142 ,  C07F9/145 ,  C07F9/46 ,  C07F9/4841 ,  C07F9/52 ,  C07F9/5721 ,  C07F9/5728 ,  C07F9/65038 ,  C07F9/65746 ,  C07F9/65848 ,  C07C47/02 ,  C07C13/23 ,  C07C69/78 ,  C07C69/24 ,  C07C69/14 ,  C07C53/10

摘要： Disclosed is a method for separating acids from chemical reaction mixtures by means of an auxiliary base. Said auxiliary base b) forms a salt with the acid, which is liquid at temperatures at which the valuable product is not significantly decomposed during separation, and c) the salt of the auxiliary base and the valuable product or the solution of the valuable product form two immiscible fluid phases in a suitable solvent.

公开(公告)号：EP1363921A1

公开(公告)日：2003-11-26

申请号：EP02701428.1

申请日：2002-02-27

申请人： Rhodia Consumer Specialties Limited

发明人： DOCHERTY, Gordon Findlay ,  DE CAMPO, Floryan

IPC分类号： C07F9/52

CPC分类号： C07F9/52 ,  C07F9/5463

摘要： Halogenated phosphines are produced by reacting a secondary phosphine with a quaternary phosphonium halide, in a solvent/carrier for the reactants.

摘要翻译： 卤化膦是通过使次膦与季鏻卤化物在反应物的溶剂/载体中反应而制得的。

公开(公告)号：EP1355912A1

公开(公告)日：2003-10-29

申请号：EP02732152.0

申请日：2002-01-18

申请人： Chirotech Technology Limited

发明人： ZANOTTI-GEROSA, Antonio,Chirotech Technology Ltd ,  MALAN, Christophe, Guillaume ,  HENSCHKE, Julian, Paul,Chirotech Technology Ltd ,  HERZBERG, Daniela,Chirotech Technology Ltd

IPC分类号： C07F9/48 ,  C07F9/52 ,  C07F9/50 ,  C07F9/6571 ,  C07F9/6584 ,  C07F9/6568 ,  C07F15/00 ,  C07B53/00 ,  C07C45/50

CPC分类号： C07B53/00 ,  C07C45/505 ,  C07C209/52 ,  C07C231/18 ,  C07C2603/92 ,  C07F9/485 ,  C07F9/4883 ,  C07F9/5027 ,  C07F9/52 ,  C07F9/65683 ,  C07F9/65719 ,  C07F9/65844 ,  C07F9/65848 ,  C07F15/0033 ,  C07F15/0073 ,  C07C211/45 ,  C07C233/36

摘要： A compound of general formula 4 wherein each of W, X, Y and Z is any substituent where a heteroatom is bonded to phosphorus, optionally linked in pairs X/Y and Z/W to form a ring, or W=X=Y=Z=H, is new. Complexes thereof can be used in asymmetric reactions such as hydrogenation.

摘要翻译： 基于ps-邻二取代对 - 环烷骨架的手性二亚膦酸酯和膦酰胺二酰胺是过渡金属，特别是铑，铱和钌的良好配体。 优选地，过渡金属通过选自2,5-降冰片二烯（NBD）和1,5-环辛二烯（COD）的二烯化合物与配体连接。