公开(公告)号：EP1893639A2

公开(公告)日：2008-03-05

申请号：EP06763632.4

申请日：2006-06-09

申请人： BASF SE

发明人： SUBKOWSKI, Thomas ,  KAROS, Marvin ,  LEMAIRE, Hans-Georg ,  BARG, Heiko ,  BOLLSCHWEILER, Claus

IPC分类号： C07K14/37

CPC分类号： C07K14/37 ,  C07K2319/00

摘要： The invention relates to polypeptides of general structural formula (I) Xn-C1-X1-50-C2-X0-5-C3-XP-C4-X1-100-C5-X1-50-C6-X0-5-C7-X1-50-C8-Xm, to their production and use thereof.

公开(公告)号：EP1891097A1

公开(公告)日：2008-02-27

申请号：EP06763497.2

申请日：2006-06-02

申请人： Novozymes A/S

发明人： VIND, Jesper ,  SEGURA, Dorotea, Raventos ,  HOEGENHAUG, Hans-Henrik Kristensen ,  MYGIND, Per, Holse ,  TABOUREAU, Olivier

IPC分类号： C07K14/37 ,  A23K1/16

CPC分类号： C07K14/37 ,  A23K20/147 ,  A23L33/18 ,  A61K38/00

摘要： The present invention relates to isolated polypeptides having antimicrobial activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

公开(公告)号：EP1868700A2

公开(公告)日：2007-12-26

申请号：EP06725389.8

申请日：2006-03-29

申请人： BASF AKTIENGESELLSCHAFT

发明人： GUZMANN, Marcus ,  ECK, Peter ,  BAUS, Ulf

IPC分类号： B01D17/05

CPC分类号： C10G33/04 ,  B01D17/042 ,  B01D17/047 ,  C07K14/37 ,  C07K2319/00 ,  C10L1/2381 ,  C10L1/2475 ,  C10L1/2683

摘要： The invention relates to hydrophobins that are especially suitable for stabilising two-phase liquid systems.

公开(公告)号：EP1862540A1

公开(公告)日：2007-12-05

申请号：EP07014762.4

申请日：2004-05-28

申请人： GENENCOR INTERNATIONAL, INC.

发明人： Foreman, Pamela ,  Goedegebuur, Frits ,  Van Solingen, Pieter ,  Ward, Michael

IPC分类号： C12N9/24 ,  C07K14/37

CPC分类号： C07K14/37 ,  C11D3/38645 ,  C12N9/18 ,  C12Y302/01004 ,  C12Y302/01091 ,  Y02E50/16

摘要： Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabinofuranosidase and one encoding an acetylxylanesterase are described. The sequences CIP1 and CIP2 contain a cellulose binding domain. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.

摘要翻译： 本文描述了从里氏木霉分离的新基因序列。 描述了编码蛋白质的两个基因，所述蛋白质包含纤维素结合结构域，一个编码阿拉伯呋喃糖苷酶和一个编码乙酰基木聚糖酯酶的蛋白质。 序列CIP1和CIP2含有纤维素结合结构域。 这些蛋白质在纺织和洗涤剂工业以及制浆造纸工业中特别有用。

公开(公告)号：EP1627049A4

公开(公告)日：2007-05-23

申请号：EP04753666

申请日：2004-05-28

申请人： GENENCOR INT

发明人： FOREMAN PAMELA ,  GOEDEGEBUUR FRITS ,  VAN SOLINGEN PIETER ,  WARD MICHAEL

IPC分类号： C12N9/00 ,  C07K14/37 ,  C12N20060101 ,  C12N9/18 ,  C12N9/24 ,  C12N15/80 ,  D06L4/40

CPC分类号： C07K14/37 ,  C11D3/38645 ,  C12N9/18 ,  C12Y302/01004 ,  C12Y302/01091 ,  Y02E50/16

摘要： Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabinofuranosidase and one encoding an acetylxylanesterase are described. The sequences CIP1 and ClP2 contain a cellulose binding domain. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.

公开(公告)号：EP1763536A1

公开(公告)日：2007-03-21

申请号：EP05788923.0

申请日：2005-07-01

申请人： Pioneer-Hi-Bred International, Inc. ,  E.I. du Pont de Nemours and Company ,  The Regents of the University of California

发明人： ALTIER, Daniel, J., Altier ,  DAHLBACKA, Glen ,  HERRMANN, Rafael ,  HUNTER-CEVERA, Jennie ,  McCUTCHEN, Billy, Fred ,  PRESNAIL, James, K. ,  SCHEPERS, Eric, J. ,  RICE, Janet, A. ,  SIMMONS, Carl, R. ,  TOROK, Tamas ,  YALPANI, Nasser ,  ELLESKAYA, I., A.

IPC分类号： C07K14/385 ,  C07K14/37

CPC分类号： C07K14/37 ,  A01N63/02 ,  A01N63/04 ,  A61K38/00 ,  C07K14/385 ,  C12N15/8282

摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

公开(公告)号：EP1646646B1

公开(公告)日：2007-03-07

申请号：EP04740916.4

申请日：2004-07-12

申请人： Vicuron Pharmaceuticals, Inc.

发明人： LAZZARINI, Ameriga ,  GASTALDO, Luciano ,  CANDIANI, Gianpaolo ,  CICILIATO, Ismaela ,  LOSI, Daniele ,  MARINELLI, Flavia ,  SELVA, Enrico ,  PARENTI, Franco

IPC分类号： C07K14/195 ,  C07K2/00 ,  C07K4/04 ,  C12P1/06 ,  A61K38/02 ,  A61P31/04 ,  A23K1/17 ,  C12R1/01

CPC分类号： C12R1/01 ,  A23K20/195 ,  A61K38/00 ,  C07K14/37 ,  C12P1/06

摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors Al and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors Al and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and van comycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.

公开(公告)号：EP1733040A2

公开(公告)日：2006-12-20

申请号：EP05740129.1

申请日：2005-03-31

申请人： DSM IP Assets B.V.

发明人： DEKKER, Petrus, Jacobus, Theodorus ,  BERG, VAN DEN, Marco Alexander

IPC分类号： C12N15/90 ,  C12N5/00

CPC分类号： C12N15/80 ,  C07K14/37 ,  C12N15/902 ,  C12P17/10 ,  C12P21/00 ,  C12P21/02 ,  C12P23/00 ,  C12P37/00

摘要： The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleotide has a region of homology with said pre-determined site, comprising steering an integration pathway towards HR. The present invention also relates to a mutant filamentous fungus originating from a parent cell, said mutant having an HR pathway with elevated efficiency and/or an NHR pathway with a lowered efficiency and/or a NHR/HR ratio with decreased efficiency as compared to said HR and/or NHR efficiency and/or NHR/HR ratio of said parent cell under the same conditions.

公开(公告)号：EP0955366B1

公开(公告)日：2006-09-06

申请号：EP96941211.3

申请日：1996-12-10

申请人： TAKARA BIO INC.

发明人： TAKESAKO, Kazutoh ,  OKADO, Takashi ,  YAGIHARA, Tomoko ,  KURODA, Masanobu ,  ONISHI, Yoshimi ,  KATO, Ikunoshin ,  AKIYAMA, Kazuo ,  YASUEDA, Hiroshi ,  YAMAGUCHI, Hideyo

IPC分类号： C12N15/31 ,  C07K14/37 ,  C07K16/14 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/00 ,  A61K39/395

CPC分类号： A61K39/0002 ,  A61K38/00 ,  A61K39/00 ,  C07K14/37 ,  C07K16/14 ,  Y10S530/858

摘要： A substantially pure, isolated antigenic protein originating in fungi of the genus Malassezia, characterized by having an avidity with IgE antibodies originating in allergic patients; antigenic fragments originating in said protein; a specific antibody against said antigenic protein or fragments; a diagnostic, therapeutic or prophylactic agent for malassezian allergic diseases containing the antigenic protein or fragments as the active ingredient; a novel recombinant malassezian antigenic protein; a gene coding for the protein; and epitopes of the protein.

公开(公告)号：EP1693381A1

公开(公告)日：2006-08-23

申请号：EP04802449.1

申请日：2004-12-10

申请人： Beijing Institute of Radiation Medicine

发明人： ZHAO, Shifu ,  ZHANG, Yong ,  YIN, Lili

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  C12N15/10 ,  A61K38/17 ,  A61P31/04

CPC分类号： C07K14/37 ,  A61K38/00 ,  C07K14/39 ,  C07K14/395 ,  C07K14/415 ,  C07K14/43545 ,  C07K14/43563 ,  C07K14/43581 ,  C07K14/445 ,  C07K14/461 ,  C07K14/47

摘要： This invention relates to Glycine-rich protein (Glyrichin), as well as its coding gene and application, especially relates to the application for antibacterial purpose. The Glyrichin of the present invention are at least one selected from the following protein families: proteins having amino acid residues in Sequence 1, 3-14 in the Sequence List or protein with antibacterial activities having 1 to 20 amino acid residues of sequence 1, 3-14 being deleted, inserted and/or substituted and with 1 to 20 amino acid residue sequences being added to the carboxyl terminal or amino terminal of Sequence 1 and 3-14 of the Sequence List correspondingly. The Glyrichin of the present invention and the coding gene can be applied to antibacterial purpose, such as the preparation of drugs for prevention and/or treatment of human or livestock infectious bacterial diseases; for the preparation of products for prevention and/or treatment of potentially infectious bacterial diseases of different kinds of creatures; for the production of transgenic creatures which can defend against diseases and pests; for the preparation of the derivatives, antagonists as well as its ligands and antibodies of Glyrichin.

摘要翻译： 本发明涉及富含甘氨酸的蛋白质（Glyrichin）及其编码基因及应用，特别涉及抗菌药物的应用。 本发明的Glyrichin是选自以下蛋白质家族中的至少一种：在序列表中的序列1〜3-14中具有氨基酸残基的蛋白质或具有序列1,3的1〜20个氨基酸残基的抗菌活性的蛋白质 -14被删除，插入和/或取代，并且相应地将1至20个氨基酸残基序列添加到序列表的序列1和3-14的羧基末端或氨基末端。 本发明的Glyrichin和编码基因可以用于抗菌目的，例如制备用于预防和/或治疗人或家畜感染性细菌性疾病的药物; 用于制备用于预防和/或治疗不同种类生物的潜在感染性细菌性疾病的产品; 用于生产可以防御疾病和害虫的转基因生物; 用于制备衍生物，拮抗剂以及其配体和Glyrichin抗体。