公开(公告)号：EP3344978A1

公开(公告)日：2018-07-11

申请号：EP16753680.4

申请日：2016-08-19

Applicant: Mettler-Toledo GmbH

Inventor： POL, Tomasz ,  KUO, Chung-Hung ,  MARKS, William Alan

IPC: G01N21/90 ,  G01N21/31 ,  G01N21/27

CPC classification number: G01N21/276 ,  G01N21/274 ,  G01N21/278 ,  G01N21/31 ,  G01N21/90 ,  G01N2021/3137 ,  G01N2201/061 ,  G01N2201/068 ,  G01N2201/08

Abstract: Apparatuses and methods are disclosed for performing a light-absorption measurement on a test sample and a compliance measurement on a reference sample. A method includes moving a reference sample receptacle carrier of an apparatus to position a first reference sample receptacle received in the carrier at a second position in a light path, directing light from an illumination system to a detection system along the light path to perform a light-absorption measurement on a first reference sample at the second position, moving the carrier to position the first receptacle out of the light path, placing a test sample receptacle in a test sample receptacle holder of the apparatus in the light path at a first position different from the second position, and directing light along the light path to perform a light-absorption measurement on a test sample in the test sample receptacle holder at the first position.

公开(公告)号：EP3161457A4

公开(公告)日：2018-05-23

申请号：EP15812820

申请日：2015-06-29

Applicant: PULSE HEALTH LLC

Inventor： THOMAS GERALD ,  YOUNG BRIAN ,  LARA JUVEN ,  NOLL CHARLES ,  INGLE JAMES

IPC: G01N21/64 ,  G01N33/497

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

公开(公告)号：EP3136951A4

公开(公告)日：2018-05-09

申请号：EP15786002

申请日：2015-04-30

Applicant: YEDA RES & DEV ,  MINI OF HEALTH ON BEHALF OF THE JERUSALEM MENTAL HEALTH CENTER

Inventor： HARMELIN ALON ,  ISRAELI DAVID ,  KUZNETSOV YURI ,  KALCHENKO VYACHESLAV

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/024 ,  A61B5/026 ,  G01N21/64 ,  G01N21/84

CPC classification number: A61B5/0035 ,  A61B5/0042 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/02007 ,  A61B5/024 ,  A61B5/0261 ,  A61B5/4064 ,  A61B2576/026 ,  G01N21/6456 ,  G01N21/84 ,  G01N2201/06113 ,  G01N2201/068

Abstract: A method of transcranial brain optical imaging including obtaining a Laser Speckle (LS) image of cranial blood vessels of a subject, obtaining a Dynamic Fluorescence (DF) image of the cranial blood vessels of the subject, and combining the LS image and the DF image producing a combined color image which displays both structure of the cranial blood vessels and perfusion of blood along the cranial blood vessels. Related apparatus and methods are also described.

公开(公告)号：EP3301025A3

公开(公告)日：2018-05-02

申请号：EP17191993.9

申请日：2017-09-20

Applicant: Honeywell International Inc.

Inventor： GARDE, Jason ,  FAN, Xiao Zhu ,  LODDEN, Grant ,  KIMMEL, Danny Thomas

IPC: B64D15/20 ,  G01S17/95 ,  G01S7/48 ,  G01N21/49 ,  G01N21/53 ,  G01N21/47

CPC classification number: G01N21/53 ,  B64D15/20 ,  B64D43/00 ,  G01N15/0211 ,  G01N15/1434 ,  G01N21/49 ,  G01N21/538 ,  G01N2015/0046 ,  G01N2021/4709 ,  G01N2201/0214 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/12 ,  G01S17/023 ,  G01S17/87 ,  G01S17/95 ,  Y02A90/19

Abstract: In one embodiment, a laser particle sensor (102) on or in a vehicle is provided. The laser particle sensor comprises an optical system (103); a processing system (116) coupled to the optical system; wherein the optical system is configured to transmit one or more laser light beams (112) to detect particles in a volume of freestream fluid (114), and to have the one or more light beams terminate on a portion of the vehicle on which the optical system is mounted; and wherein the optical system is configured to receive a backscattered portion of the one or more laser light beams transmitted by the optical system.

公开(公告)号：EP3186617A4

公开(公告)日：2018-04-25

申请号：EP15835461

申请日：2015-08-26

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： GROT ANNETTE ,  SAXENA RAVI ,  LUNDQUIST PAUL

IPC: G01N21/64 ,  G01N21/77 ,  G02B5/18 ,  G02B5/20 ,  G02B5/28 ,  G02B6/12 ,  G02B6/132 ,  G02B6/136 ,  G02B27/42 ,  H01L27/146

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/78 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2021/7756 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0873 ,  G02B5/1895 ,  G02B5/201 ,  G02B5/285 ,  G02B6/132 ,  G02B6/136 ,  G02B27/4238 ,  G02B27/4244 ,  G02B2006/12102 ,  G02B2006/12109 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14685

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

公开(公告)号：EP2871463B1

公开(公告)日：2018-02-21

申请号：EP14192873.9

申请日：2014-11-12

Applicant: Ludwig-Maximilians-Universität München

Inventor： Paulitschke, Philipp ,  Rädler, Joachim

IPC: G01N21/47 ,  G01N33/543

CPC classification number: G01N21/4788 ,  C12Q1/18 ,  G01N33/5029 ,  G01N2201/06113 ,  G01N2201/068

公开(公告)号：EP3155406A4

公开(公告)日：2018-01-31

申请号：EP15805743

申请日：2015-03-03

Applicant: VOELCKER NICOLAS HANS

Inventor： VOELCKER NICO ,  KRISMASTUTI FRANSISKA SRI HERWAHYU ,  PRIETO SIMON BEATRIZ

IPC: G01N21/64 ,  G01N33/573

CPC classification number: G01N21/6428 ,  G01N33/573 ,  G01N2021/6432 ,  G01N2201/068 ,  G01N2333/95

Abstract: Provided herein is an optical biosensor for detecting a target bioanalyte in a sample. The biosensor includes: a porous silicon or alumina substrate having a surface and a detection agent immobilised on the surface. The detection agent includes a sensing domain and a signaling domain, the sensing domain having a linker capable of interacting with the target bioanalyte and the signaling domain having a luminescence donor and a luminescence acceptor wherein the luminescence donor and the luminescence acceptor are connected by the linker and are optically coupled in the absence of the target bioanalyte. Emission of light from the luminescence donor is substantially quenched by the luminescence acceptor, and interaction of the target bioanalyte with the linker results in optical un-coupling of the luminescence donor and the luminescence acceptor to thereby result in light emission from the luminescence donor.

公开(公告)号：EP3259579A2

公开(公告)日：2017-12-27

申请号：EP16723498.8

申请日：2016-02-19

Applicant: Premium Genetics (UK) Limited

Inventor： MATTHIAS, Wagner

IPC: G01N21/3577 ,  G01N21/39 ,  G01N21/53

CPC classification number: G01N15/1436 ,  G01N15/00 ,  G01N15/06 ,  G01N15/1434 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N21/39 ,  G01N21/53 ,  G01N21/552 ,  G01N2015/0065 ,  G01N2015/0687 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1443 ,  G01N2015/1447 ,  G01N2015/1488 ,  G01N2015/1497 ,  G01N2021/399 ,  G01N2201/068 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/006 ,  G02B21/0064 ,  G02B21/008

Abstract: An analyzer of a component in a sample fluid includes an optical source and an optical detector defining a beam path of a beam, wherein the optical source emits the beam and the optical detector measures the beam after partial absorption by the sample fluid, a fluid flow cell disposed on the beam path defining an interrogation region in the a fluid flow cell in which the optical beam interacts with the sample fluid and a reference fluid; and wherein the sample fluid and the reference fluid are in laminar flow, and a scanning system that scans the beam relative to the laminar flow within the fluid flow cell, wherein the scanning system scans the beam relative to both the sample fluid and the reference fluid.

公开(公告)号：EP3254082A1

公开(公告)日：2017-12-13

申请号：EP16707298.2

申请日：2016-02-05

Applicant: Life Technologies Corporation

Inventor： MARKS, Jeffrey

IPC: G01N21/27 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

公开(公告)号：EP3093665A4

公开(公告)日：2017-09-20

申请号：EP15735557

申请日：2015-01-07

Applicant: KONICA MINOLTA INC

Inventor： NODA TETSUYA

IPC: G01N21/64 ,  G01N33/543

CPC classification number: G01N33/54373 ,  G01N21/648 ,  G01N21/6486 ,  G01N33/543 ,  G01N2021/6417 ,  G01N2201/06113 ,  G01N2201/068

Abstract: Provided are an immunoassay method in which, by using a sensor chip on which a plurality of capture regions which capture a material to be detected by a first capturing body are arranged separated from each other, the material to be detected captured by the first capturing body is individually detected, wherein the plurality of capture regions are formed by using a different type of first capturing body depending on the type of a material to be detected to be captured, the method having: a detection processing order determination step of determining a detection processing order between the capture regions based on information about a detection processing order between the plurality of the capture regions; and a detection processing step of performing a detection processing for each of the capture regions according to the detection processing order between the plurality of the capture regions, and an immunoassay system using the method.

Abstract translation: 本发明提供一种免疫测定方法，其中，通过使用将捕捉第一捕捉体检测对象物质的多个捕捉区域分离的传感器芯片，将由第一捕捉体捕捉的检测对象物质 所述方法具有：检测处理顺序确定步骤，用于确定检测处理的检测处理顺序确定步骤，其中，所述检测处理顺序确定步骤根据待检测材料的类型来检测所述多个捕获区域， 基于关于多个捕获区域之间的检测处理顺序的信息在捕获区域之间的顺序; 以及检测处理步骤，根据多个捕捉区域之间的检测处理顺序，针对每个捕捉区域执行检测处理，以及使用该方法的免疫测定系统。