公开(公告)号：EP0911625B1

公开(公告)日：2005-06-08

申请号：EP98117028.5

申请日：1998-09-09

申请人： Degussa AG

发明人： Krieger, Klaus-Dieter, Dr. ,  Zehe, Lothar ,  Rauleder, Hartwig, Dr.

IPC分类号： G01N21/35 ,  G01N30/74

CPC分类号： G01N21/3577

公开(公告)号：EP0717839B1

公开(公告)日：2003-12-10

申请号：EP94906655.9

申请日：1994-01-12

申请人： Applera Corporation

发明人： SAPP, Edwin ,  WEINBERGER, Robert

IPC分类号： G01N21/05 ,  G01N21/64 ,  G01N30/74

CPC分类号： G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/645 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2021/6482 ,  G01N2201/0642

摘要： A fluorescence flow cell (10) having a capillary (11) through which a sample fluid is moved, an optical source (15) that directs an exposing beam of light through the sample fluid, a collector (113) that collects fluorescent light from the exposed region of the sample and directs such collected light to a detector (114). A beam blocker (123) prevents light that is scattered by the capillary walls from reaching the detector, thereby improving the signal-to-noise ratio of the system. The beam blocker also has a pair of legs (22, 23) that prevent the sample fluid from being exposed by either the exposing light or the collected light outside of the exposing region. The structure of the components enables the various components to be quickly and accurately assembled and enables easy replacement of the capillary.

公开(公告)号：EP1308723A2

公开(公告)日：2003-05-07

申请号：EP03003139.7

申请日：1999-04-02

申请人： Symyx Technologies, Inc.

发明人： Carlson, Eric ,  Safir, Adam ,  Petro, Miroslav ,  Nielson, Ralph, B., ,  Lee, Thomas, S. ,  Frechet, Jean, M.J., ,  Dales, G., Cameron, ,  Kuebler, Sigrid, C., ,  Bennett,James

IPC分类号： G01N30/74 ,  G01N33/44

CPC分类号： G01N35/1097 ,  B01D15/12 ,  B01D15/14 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/26 ,  B01J20/28078 ,  B01J2219/00119 ,  B01J2219/00274 ,  G01N15/0205 ,  G01N30/16 ,  G01N30/30 ,  G01N30/60 ,  G01N30/6052 ,  G01N33/44 ,  G01N33/442 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/347 ,  G01N2030/885 ,  G01N2030/8886

摘要： A method for characterising a non-biological polymer sample, the method comprising injecting a non-biological polymer sample into a mobile phase of a continuous-flow light-scattering detector, advancing the injected sample toward a detection cavity of the detector, the flowrate of the sample-containing mobile phase having an advancing flowrate, V ADVANCE , while the injected sample is advanced toward the detection cavity, reducing the flowrate of the sample-containing mobile phase to a detection flowrate, V DETECT , detecting light scattered from the injected sample or from a component thereof in the detection cavity of the detector while the mobile-phase flowrate is reduced to the detection flowrate, V DETECT , and flushing the sample from the detection cavity after detecting the scattered light.

摘要翻译： 一种用于表征非生物聚合物样品的方法，所述方法包括将非生物聚合物样品注入连续流光散射检测器的流动相中，将注入的样品推向检测器的检测腔，流速 含有样品的流动相具有提前的流速VADVANCE，同时注入的样品朝向检测腔前进，将包含样品的流动相的流量降低到检测流量VDETECT，检测从注入的样品散射的光或从 其检测器的检测腔中的成分被移动相流量降低到检测流量VDETECT，并且在检测到散射光后从检测腔中冲洗样品。

公开(公告)号：EP0626574B1

公开(公告)日：2003-01-02

申请号：EP94109752.9

申请日：1989-03-23

申请人： THE PERKIN-ELMER CORPORATION

发明人： Paradis, Roland C.

IPC分类号： G01N21/05 ,  G01N30/74

CPC分类号： G01N30/74 ,  G01N21/05 ,  G01N21/09 ,  G01N2021/0346 ,  G01N2030/746

公开(公告)号：EP0523680B1

公开(公告)日：2002-01-23

申请号：EP92112114.1

申请日：1992-07-15

申请人： Waters Investments Limited

发明人： Gilby, Anthony C. ,  Carson, William W.

IPC分类号： G01N21/05 ,  G01N27/447 ,  G01N30/74

CPC分类号： G02B6/032 ,  G01N21/0303 ,  G01N21/05 ,  G01N2021/0346 ,  Y10S138/03 ,  G01N30/74

公开(公告)号：EP1132738A1

公开(公告)日：2001-09-12

申请号：EP01105606.6

申请日：2001-03-06

申请人： Alltech Associates, Inc.

发明人： Benedict, Bart C.

IPC分类号： G01N30/74 ,  G01N21/47

CPC分类号： G01N30/74 ,  G01N15/065 ,  G01N2015/0261 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N21/47

摘要： The present invention is directed to a device for evaporative light scattering detection that can be used for a wide range of sample types and mobile phases. The device may be quickly converted between a single flow and a split flow configuration through the use of a retractable impactor (105). The drift tube (104) of the device is in flow communication with the nebulizer (102) of the device, the drift tube (104) comprising a drain outlet (110) and the retractable impactor (105) positioned downstream in the direction of flow from the nebulizer (102).

公开(公告)号：EP1002227A4

公开(公告)日：2000-10-04

申请号：EP97948431

申请日：1997-11-21

申请人： UNIV WASHINGTON

发明人： WEIGL BERNHARD H ,  HOLL MARK R ,  ZEBERT DIANE ,  KENNY MARGARET ,  WU CAICAI

IPC分类号： G01N31/20 ,  B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N15/10 ,  G01N15/14 ,  G01N21/64 ,  G01N30/00 ,  G01N30/38 ,  G01N30/60 ,  G01N30/74 ,  G01N35/00 ,  G01N35/08 ,  G01N37/00 ,  G01N15/06 ,  G01N21/05

CPC分类号： B01F13/0093 ,  B01F5/0403 ,  B01F13/0059 ,  B01J19/0093 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/148 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1404 ,  G01N15/1484 ,  G01N30/0005 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N35/085 ,  G01N2035/00237 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A reference T-sensor system is provided for detecting the presence and/or measuring the concentration of analyte particles in a sample stream comprising a laminar flow channel (100), three or more inlet means (40, 50, 55) in fluid connection with the laminar flow channel (100) for respectively conducting into the laminar flow channel an indicator stream (70) which may comprise an indicator substance which indicates the presence of the analyte particles by a detectable change in property when contacted with analyte particles, the sample stream (80), and a reference stream (75), which can be either a control stream or an internal standard stream or both.

公开(公告)号：EP0666982B1

公开(公告)日：1998-10-07

申请号：EP93908259.0

申请日：1993-04-07

申请人： Amersham Pharmacia Biotech AB

发明人： BIRNBAUM, Staffan ,  JOHANSSON, Jonas ,  LARSSON, Per-Olof ,  MIYABAYASHI, Akiyoshi ,  MOSBACH, Klaus ,  NILSSON, Staffan ,  SVANBERG, Sune ,  WAHLUND, Karl-Gustav

IPC分类号： G01N27/447 ,  G01N30/74 ,  G01N21/64

CPC分类号： G01N27/44721 ,  G01N30/6082 ,  G01N30/74

摘要： This invention comprises, on one hand, a method of detecting and quantifying components separated by capillary electrophoresis or other technique using thin capillaries in the separation, and on the other hand, an apparatus for performing this detection. The method comprises irradiating the whole or large parts of the capillary at short time intervals and detecting the fluorescence originating from the sample components, preferably by a so-called CCD detector (charge coupled device). Thereby an instantaneous image of the progress of the separation process is obtained.

公开(公告)号：EP0762119A1

公开(公告)日：1997-03-12

申请号：EP95113947.6

申请日：1995-09-06

申请人： Hewlett-Packard GmbH

发明人： Kaltenbach, Patrick

IPC分类号： G01N30/74 ,  G01N21/05 ,  G01N27/447

CPC分类号： G01N21/05 ,  G01N27/44721 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2030/746 ,  G01N2201/0642

摘要： A photometric apparatus (100) for small sample volumes comprises a cell body (102), a light input means (104) arranged adjacent to a first surface of the cell body (102), a light source (105) emitting light of predetermined wavelength or wavelength range through the light input means (104), a light output means (106) arranged adjacent to a second surface of the cell body (102) opposite to the first surface, a light detector (107) arranged adjacent to the light out put means (104), and a flow channel (108) formed in the cell body (102), wherein surfaces of the walls of the channel (108) have a roughness smaller than the predetermined wavelength.

摘要翻译： 用于小样品体积的测光装置（100）包括电池体（102），与电池体（102）的第一表面相邻布置的光输入装置（104），发射预定波长的光的光源（105） 或波长范围，与该第一表面相对的与电池体（102）相邻的第二表面相邻布置的光输出装置（106），与该光出射相邻布置的光检测器（107） 放置装置（104）和形成在电池体（102）中的流动通道（108），其中通道（108）的壁的表面具有小于预定波长的粗糙度。

公开(公告)号：EP0505564B1

公开(公告)日：1997-01-02

申请号：EP92900681.5

申请日：1991-10-23

申请人： THE PERKIN-ELMER CORPORATION

发明人： DOLLINGER, Gavin, D. ,  CUNICO, Robert, L. ,  KUNITANI, Michael, G.

IPC分类号： G01N15/02 ,  G01N30/74

CPC分类号： G01N15/0205 ,  G01N15/04 ,  G01N21/532 ,  G01N30/74 ,  G01N33/68 ,  G01N2021/4726 ,  Y10T436/25375

摘要： A high angle light scattering detector using classical Rayleigh scattering. A high intensity arc light source, filtered to leave only one wavelength illuminates a flow cell. Through the flow cell, very small particles such as biological proteins flow in solution after separation by HPLC or some other means. A UV detector generates data regarding the weight concentration of the eluting particles and a scattered light detector collecting scattered light at angles of approximately 90° generates a scattered light signal. The incident light intensity is also measured. The average molecular weight is then computed using the scattered and incident light data, the weight concentration data and a simplified mathematical relationship from which the size factor P and the viral coefficients have been eliminated.