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公开(公告)号：EP2231589B1
公开(公告)日：2013-02-13
申请号：EP08859523.6
申请日：2008-12-10
申请人： Theravance, Inc.
IPC分类号： C07C229/28 , C07C229/34 , C07C237/06 , C07C237/14 , C07C237/20 , C07C237/48 , C07D295/185 , A61K31/165 , A61K31/166 , A61K31/197 , A61K31/216 , A61K31/45 , A61K31/495 , A61P1/00
CPC分类号： C07C237/48 , A61K9/0019 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K47/12 , A61K47/14 , A61K47/26 , C07C229/28 , C07C229/34 , C07C237/06 , C07C237/14 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D295/185
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52.发明公开METHOD OF PRODUCING OPTICALLY ACTIVE AMINO ACID DERIVATIVE 审中-公开VERFAHREN ZUR HERSTELLUNG EINES OPTISCH AKTIVENAMINOSÄUREDERIVATS
公开(公告)号：EP2298729A4
公开(公告)日：2012-12-19
申请号：EP09758313
申请日：2009-06-02
申请人： KANEKA CORP
发明人： YAMAMOTO SHOHEI , FUJII AKIO , MITSUDA MASARU
IPC分类号： C07C227/18 , C07B51/00 , C07B53/00 , C07B61/00 , C07C229/08 , C07C229/28 , C07D207/12 , C07D211/60 , C07D295/18 , C07D403/12 , C07D495/04
CPC分类号： C07B51/00 , C07B53/00 , C07C227/18 , C07C229/08 , C07C229/28 , C07C2601/02 , C07D207/12 , C07D211/60 , C07D295/18 , C07D403/12 , C07D495/04
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53.发明公开Methods and compounds for producing dipeptidyl peptidase iv inhibitors and intermediates thereof 无效的方法和化合物用于制备它们的二肽基肽酶IV抑制剂和中间体的
公开(公告)号：EP2505579A2
公开(公告)日：2012-10-03
申请号：EP12162633.7
申请日：2003-12-04
发明人： VU, Truc, Chi , KOLOTUCHIN, Sergei, V. , MAZZULLO, John, A., Jr. , WANG, Jianji , WONG, Kwok , YU, Jurong , ZHU, Jason
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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54.发明公开OPTICALLY ACTIVE VINYL-CYCLOPROPANE CARBOXYLIC ACID DERIVATIVE AND OPTICALLY ACTIVE VINYL-CYCLOPROPANE AMINO ACID DERIVATIVE MANUFACTURING METHOD 审中-公开光学活性乙烯基环丙烷羧酸衍生物和工艺生产光学活性乙烯基环丙烷羧酸衍生物
公开(公告)号：EP2345633A4
公开(公告)日：2012-05-16
申请号：EP09819272
申请日：2009-10-09
申请人： KANEKA CORP
发明人： TANAKA TATSUYOSHI , OKURO KAZUMI
IPC分类号： C07C69/757 , C07C67/52 , C07C211/27 , C07C211/29 , C07C211/30 , C07C227/32 , C07C229/28 , C07C231/20 , C07C235/82 , C07C269/04 , C07C271/24
CPC分类号： C07C227/32 , C07C67/347 , C07C233/58 , C07C271/24 , C07C2601/02 , C07C69/743 , C07C229/48
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公开(公告)号：EP1939170A4
公开(公告)日：2010-04-07
申请号：EP06722414
申请日：2006-04-28
申请人： NHWA PHARMA CORP
发明人： PENG ZHENYUN , ZHU WEI
IPC分类号： C07C229/28 , C07C221/00 , C07C227/22 , C07C231/10 , C07C233/00 , C07D221/20
CPC分类号： C07C227/22 , C07C2601/14 , C07D221/20 , C07C229/28
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公开(公告)号：EP2007710A1
公开(公告)日：2008-12-31
申请号：EP08726267.1
申请日：2008-02-28
发明人： DEE-NOOR, Ziv , GOLD, Amir
IPC分类号： C07C227/16 , C07C229/28
CPC分类号： C07C227/16 , C07C229/28
摘要： This invention relates to an efficient process for converting gabapentin hydrochloride salt to gabapentin by liquid-liquid extraction using a counter-current extraction method.
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57.发明公开STEREOSELECTIVE SYNTHESIS OF 3,4-DISUBSTITUTED CYCLOPENTANONES AND RELATED COMPOUNDS 审中-公开维生素VERBINDUNGEN的立体合成芴3,4-二异丁基环丙烷
公开(公告)号：EP1912936A2
公开(公告)日：2008-04-23
申请号：EP06779907.2
申请日：2006-07-13
发明人： BETCHE, Hans-Juergen , IRDAM, Erwin, Ayandra , PADILLA, Amphlett, Greg , PEARLMAN, Bruce , PERRAULT, William, Pfizer Global Research and Dev. , VANALSTEN, John, Pfizer Global Research and Dev. , FRANCZYK, Thaddeus, Pfizer Global Rch. and Dev. , ERDMAN, David Thomas
IPC分类号： C07C317/12 , C07C321/22 , C07C309/25 , C07C229/28 , C07C45/51 , C07C49/395
CPC分类号： C07C45/518 , C07B2200/07 , C07C51/09 , C07C67/343 , C07C69/757 , C07C309/25 , C07C319/20 , C07C321/22 , C07C323/65 , C07C2601/08 , C07C49/395 , C07C55/02 , C07C69/608
摘要： Methods and materials for preparing optically active 3,4-disubstituted cyclopentanones are disclosed. The method includes hydrolyzing one or more compounds represented by Formula (13), or removing an ester moiety from a compound represented by Formula (18).
摘要翻译： 公开了用于制备光学活性3,4-二取代的环戊酮的方法和材料。 该方法包括水解一种或多种由式（13）表示的化合物，或从式（18）表示的化合物中除去酯部分。
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58.发明公开
公开(公告)号：EP1900721A1
公开(公告)日：2008-03-19
申请号：EP06752998.2
申请日：2006-06-21
发明人： WANG, Mingwei No.555 Zuchongzhi Road , LI, Na No.555 Zuchongzhi Road , WANG, Guangxing No.555 Zuchongzhi Road , XIE, Xin No.555 Zuchongzhi Road , LIU, Qing No.555 Zuchongzhi Road , ZHOU, Caihong No.555 Zuchongzhi Road , NAN, Fajun No.555 Zuchongzhi Road
IPC分类号： C07C69/74 , C07C69/75 , C07C229/28 , C07D213/16 , C07D401/08 , C07D401/14 , A61K31/4412 , A61P3/10
CPC分类号： C07D333/38
摘要： The present invention provides a substituted cyclic compound of the following general formula I or II:
its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metalbolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.摘要翻译： 本发明提供以下通式I或II一个substituiertem环状化合物：及其制备方法和其作为胰高血糖素样肽-1受体调节剂用于预防或治疗metalbolic病症，包括使用，但不限于，糖尿病，胰岛素抗性 和肥胖等。
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59.发明公开ANALOGS OF 4-HYDROXYISOLEUCINE AND USES THEREOF 审中-公开4-HYDROXYISOLEUCIN-ANALOGA UND IHRE VERWENDUNGEN
公开(公告)号：EP1858840A2
公开(公告)日：2007-11-28
申请号：EP06765562.1
申请日：2006-02-17
申请人： Innodia Inc. , Centre National de la Recherche Scientifique , UNIVERSITE LOUIS PASTEUR (STRASBOURG I)
IPC分类号： C07C229/22 , C07C229/36 , C07C229/28 , C07D207/16 , C07D405/06 , C07D211/60 , C07C229/30 , C07D295/18 , C07C311/19 , C07C271/22 , C07C229/12 , C07C229/50 , C07C309/18 , C07D257/04
CPC分类号： C07C229/22 , C07B2200/07 , C07C229/28 , C07C229/30 , C07C229/36 , C07C229/50 , C07C271/22 , C07C309/18 , C07C311/19 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/16 , C07D211/60 , C07D211/78 , C07D257/04 , C07D261/18 , C07D265/06 , C07D295/185 , C07D307/33 , C07D405/06 , C07D491/08 , C07F9/3808
摘要： The invention relates to analogs of 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The analogs of the invention stimulate both glucose uptake and insulin secretion, and might thus be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.
摘要翻译： 本发明涉及4-羟基异亮氨酸的类似物及其内酯，其药学上可接受的盐和前药，其制备方法以及包含其的药物组合物。 本发明的类似物刺激葡萄糖摄取和胰岛素分泌，因此可用于预防和治疗糖或脂质代谢紊乱，包括糖尿病（1型和2型糖尿病），前期糖尿病和代谢综合征 。
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公开(公告)号：EP1841725A1
公开(公告)日：2007-10-10
申请号：EP05823475.8
申请日：2005-12-15
申请人： ZaCh System S.p.A.
IPC分类号： C07C227/40 , C07C229/28
CPC分类号： C07D209/54 , C07C227/42 , C07C229/28
摘要： The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
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