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    COMPOSITE BIOLOGICAL-MOLECULE-ACCRETION MATERIAL
    52.
    发明公开
    COMPOSITE BIOLOGICAL-MOLECULE-ACCRETION MATERIAL 失效
    ZUSAMMENGESETZTES材料ZUM ANSATZ VON BIOLOGISCHENMOLEKÜLEN

    公开(公告)号：EP0713423A4

    公开(公告)日：1996-09-11

    申请号：EP94925877

    申请日：1994-08-12

    申请人： ALLEN RICHARD G

    发明人： ALLEN RICHARD G

    IPC分类号： C12N15/09 ,  B01J20/20 ,  B01J20/26 ,  B01J20/32 ,  B01J47/00 ,  C07K17/08 ,  C07K17/10

    CPC分类号： B01J20/20 ,  B01J20/261 ,  B01J20/262 ,  B01J20/3204 ,  B01J20/3274 ,  B01J20/3295 ,  B01J2220/46 ,  B01J2220/4825 ,  B01J2220/56

    摘要： A composite biological-molecule-accretion material (10) is described for extracting desired target biological molecules from aqueous solution (24) and substantially permanently binding to those molecules. The material (10) includes a first component (10a &cir& _) designed with a binding affinity for proteins and peptides in such solution, and a second component (10b &cir& _) designed with a binding affinity for nucleic acids in such solution. The material (10) is capable of being formed in a body (12) for passing such solution through it, and such passing has the effect of removing the proteins, peptides and nucleic acids from such solution and binding them to the body. That binding is substantially permanent so that subsequent passage of additional aqueous solution will not unbind substantially the accreted proteins, peptides and nucleic acids. The first component (10a &cir& _) may include dextran-coated (10a &cir& _2) activated charcoal particles (10a &cir& _1), and the second component may include an anion-exchange resin and a cation-exchange resin. Preferred relative volumes of both components are 1:1. Also described is a method for extracting desired target biological molecules from aqueous solution and substantially permanently binding them to a solid, and a method of filtering target biological molecules out of water.

    摘要翻译： 描述了用于从水溶液（24）中提取期望的目标生物分子并基本上永久地结合这些分子的复合生物分子增加材料（10）。 材料（10）包括设计成对这种溶液中的蛋白质和肽具有结合亲和力的第一组分（10a）和设计成对这种溶液中的核酸具有结合亲和力的第二组分（10b）。 材料（10）能够形成在主体（12）中，以使这种溶液通过它，并且这种通过具有从这种溶液中除去蛋白质，肽和核酸并将它们结合到身体上的作用。 该结合基本上是永久性的，以便随后的另外的水溶液的通过不会基本解除与增生的蛋白质，肽和核酸的结合。 第一组分（10a）可以包括葡聚糖包被的（10a→2）活性炭颗粒（10a→1），第二组分可以包括阴离子交换树脂和阳离子交换树脂。 两种组分的优选相对体积为1：1。 还描述了用于从水溶液中提取期望的目标生物分子并将它们基本上永久地结合到固体上的方法，以及将目标生物分子从水中过滤的方法。

    Compositions and methods for stimulating megakaryocyte growth and differentiation
    55.
    发明公开
    Compositions and methods for stimulating megakaryocyte growth and differentiation 失效
    组合物和方法用于刺激巨核细胞的生长和分化

    公开(公告)号：EP0690127A1

    公开(公告)日：1996-01-03

    申请号：EP95104745.5

    申请日：1995-03-30

    申请人： AMGEN INC.

    发明人： Bartley, Timothy D. ,  Bogenberger, Jakob M. ,  Bosselman, Robert A. ,  Hunt, Pamela ,  Samal, Babru B. ,  Kinstler, Olaf B.

    IPC分类号： C12N15/19 ,  C07K14/52 ,  C07K17/08 ,  A61K38/19 ,  A61K47/48

    CPC分类号： C07K17/08 ,  A61K38/00 ,  A61K47/60 ,  C07K14/524 ,  Y10S930/14

    摘要： Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.

    摘要翻译： 本发明公开了新的蛋白质，通过向称为巨核细胞生长和发育因子（MGDFs，所以基因反弹由被称为的Mpl配体），确实有刺激巨核细胞的生长，以及增加巨核细胞的分化或成熟的生物活性，最终导致 血小板生成。 MGDF衍生物包括附接到水溶性聚合物，聚乙二醇分子MGDF：如，被游离缺失盘，地连同它们的制备方法。 所以光盘游离缺失是从天然来源同质的形式获得的MGDFs和由哺乳动物重组基因工程技术，包括人类生产它们的过程。