公开(公告)号：EP1346730A1

公开(公告)日：2003-09-24

申请号：EP03008765.4

申请日：1994-12-07

申请人： NEORX CORPORATION

发明人： Theodor, Louis J. ,  Meyer, Damon L. ,  Mallet, Robert W. ,  Kasina, Sudhakar ,  Reno, John M. ,  Axworthy, Donald B. ,  Gustavson, Linda M.

IPC分类号： A61K47/48 ,  A61P7/02

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/557 ,  A61K47/6851 ,  A61K47/6897 ,  A61K48/00 ,  A61K51/1093 ,  A61K2039/505 ,  C07F13/005 ,  C07K14/765 ,  C07K16/30 ,  C12N15/87

摘要： In one aspect the invention includes an "antibody cocktail" approach to multi-step targeting of an active agent to a target site. This comprises administering multiple targeting moiety conjugates, wherein the targeting moieties are antibodies with nonoverlapping patterns of cross-reactivity for epitopes at the target site and wherein each targeting conjugate has a ligand or anti-ligand that is complementary to a corresponding anti-ligand or ligand on the active agent conjugate. In a further aspect the invention includes a multi-step method for targeting specifically a thrombolytic agent to the site of a thrombus, wherein the targeting moiety may be an annexin. In another aspect annexin may be the targeting moiety in a multi-step method for delivery of an active agent to a site having exposed anionic membrane lipids. In a final aspect, the invention includes specifically the compound biotinamido-N-methylglycyl-seryl-O-succinamido-benzyl DOTA, a chelating structure which may be used to deliver radiometals to a target site.

摘要翻译： 在一个方面，本发明包括用于将活性剂多步靶向目标部位的“抗体混合物”方法。 这包括施用多个靶向部分缀合物，其中靶向部分是在靶位点处表位具有不重叠的交叉反应模式的抗体，并且其中每个靶向缀合物具有与相应的抗配体或配体互补的配体或抗配体 在活性剂缀合物上。 在另一方面，本发明包括用于将血栓溶解剂特异性靶向血栓部位的多步法，其中靶向部分可以是膜联蛋白。 在另一方面，膜联蛋白可以是用于将活性剂递送到具有暴露的阴离子膜脂质的部位的多步骤方法中的靶向部分。 在最后方面，本发明具体包括化合物生物素酰氨基-N-甲基甘氨酰 - 丝氨酰基-O-琥珀酰氨基 - 苄基DOTA，其可用于将靶向部位递送放射性金属的螯合结构。

公开(公告)号：EP1187856B1

公开(公告)日：2003-09-10

申请号：EP00919456.4

申请日：2000-03-17

申请人： Dow Global Technologies Inc.

发明人： DEVORE, David, D. ,  FENG, Shaoguang, S. ,  FRAZIER, Kevin, A. ,  PATTON, Jasson, T.

IPC分类号： C08F10/00 ,  C08F4/60 ,  C07F5/00 ,  C07F7/00 ,  C07F9/00 ,  C07F11/00 ,  C07F13/00 ,  C07F15/00

CPC分类号： C08F10/06 ,  C07F5/003 ,  C07F7/006 ,  C07F9/005 ,  C07F11/005 ,  C07F13/005 ,  C07F15/025 ,  C08F10/00 ,  C08F110/06 ,  C08F4/619 ,  C08F4/52 ,  C08F4/64089 ,  C08F4/69224 ,  C08F4/68224 ,  C08F4/60089 ,  C08F2500/03 ,  C08F2500/15 ,  C08F4/7042

摘要： Metal complexes comprising a polydentate chelating group, catalysts and polymerization processes using the same for the polymerization of olefins, especially propylene, are disclosed.

公开(公告)号：EP1001009B1

公开(公告)日：2003-09-03

申请号：EP98309169.5

申请日：1998-11-10

申请人： UNILEVER PLC ,  UNILEVER N.V.

发明人： Delroisse, Michel Gilbert Jose ,  Hage, Ronald Unilever Research Vlaardingen ,  Kalmeijer, Robertus Everardus ,  Lamers, Christiaan Unilever Research Vlaardingen ,  Russell, Stephen William, Unilever Vlaardingen ,  Whittaker, Jane ,  Feringa, Bernard Lucas University of Groningen ,  Hermant, Roelant Mathijs Unilever Res. Vlaardingen ,  Koek, Jean Hypolites Unilever Res. Vlaardingen ,  Rispens, Minze Theunis University of Groningen ,  van Vliet, Ronaldus Theodorus Leonardus

IPC分类号： C11D3/395 ,  D06L3/02 ,  C07F15/02 ,  C07F1/08 ,  C07F13/00 ,  B01J31/18

CPC分类号： C11D3/3932 ,  B01J31/1815 ,  B01J2531/16 ,  B01J2531/72 ,  B01J2531/842 ,  C07F1/005 ,  C07F13/005 ,  C07F15/025 ,  D06L4/12

公开(公告)号：EP0966323B1

公开(公告)日：2003-09-03

申请号：EP98904334.4

申请日：1998-03-06

申请人： The Procter & Gamble Company

发明人： BUSCH, Daryle, Hadley ,  COLLINSON, Simon Robert ,  HUBIN, Timothy, Jay

IPC分类号： B01J31/18 ,  C07F13/00

CPC分类号： C11D3/3932 ,  B01J31/182 ,  B01J2231/70 ,  B01J2231/72 ,  B01J2531/0238 ,  B01J2531/0258 ,  B01J2531/16 ,  B01J2531/56 ,  B01J2531/62 ,  B01J2531/64 ,  B01J2531/66 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07F13/005

公开(公告)号：EP0955289B1

公开(公告)日：2003-05-07

申请号：EP99810266.9

申请日：1999-03-29

申请人： Ciba Specialty Chemicals Holding Inc.

发明人： Bachmann, Frank ,  Dannacher, Josef ,  Makowka, Cornelia ,  Schlingloff, Gunther ,  Weingartner, Peter ,  Richter, Grit

IPC分类号： C07C251/24 ,  C11D3/395

CPC分类号： C07C251/24 ,  C07F13/005 ,  C11D3/0021 ,  C11D3/168 ,  C11D3/3932

公开(公告)号：EP1087969B1

公开(公告)日：2003-04-09

申请号：EP99957058.3

申请日：1999-06-10

申请人： UNILEVER PLC ,  UNILEVER N.V.

发明人： BANSE, Frédéric, Lab. de Chimie Inorganique ,  CARINA, Riccardo, Unilever Research Port Sunlight ,  DELROISSE, Michel, Unilever Res. Port Sunlight ,  GIRERD, Jean-Jacques, Lab. de Chimie Inorganique ,  HAGE, Ronald, Unilever Research Vlaardingen ,  SIMAAN, Jalila Ariane, Lab. de Chimie Inorganique ,  TETARD, David, Unilever Research Port Sunlight

IPC分类号： C07D471/18 ,  C11D3/39

CPC分类号： C07F13/005 ,  C07F15/025 ,  C11D3/3932 ,  D06L4/13 ,  D06L4/15

摘要： A bleach catalyst in the form of a ligand of formula (I); wherein Z and Z are independently selected from monocyclic or polycyclic aromatic ring structures optionally containing one or more heteroatoms, each aromatic ring structure being optionally substituted by one or more substituents. Y and Y are independently selected from C, N, O, Si, P and S atoms. A and A are independently selected from hydrogen, alkyl, alkenyl and cycloalkyl (each of alkyl, alkenyl and cycloalkyl being optionally substituted, electron donating groups and electron withdrawing groups); i and j are selected from 0, 1 and 2 to complete the valency of the groups Y and Y each of Q -Q is independently selected from groups of formula (a); wherein 10 > a + b + c + d > = 2; each Y is independently selected from O, S, SO, SO2, (G )(G )N-C(O), aryl, heteroaryl, P and P(O) each of A -A is independently selected from the groups hereinbefore defined for A and A ; ion pairs, complexes and the use of such ligands, ion pairs and complexes in cleaning and/or bleaching compositions are also described.

摘要翻译： 本发明涉及新的大环漂白催化剂，包含这些催化剂的制剂，以及采用这些催化剂的漂白方法。 这些催化剂表现出意想不到的水解稳定性，以及金属萃取剂对金属萃取的稳定性。

公开(公告)号：EP1268497A1

公开(公告)日：2003-01-02

申请号：EP01924822.8

申请日：2001-04-06

申请人： Bristol-Myers Squibb Pharma Company

发明人： LIU, Shuang

IPC分类号： C07F9/50 ,  C07F13/00 ,  C07H13/08 ,  C07B59/00 ,  A61K51/04 ,  C07K14/745 ,  C07K7/02 ,  C07K5/02 ,  C07K7/06

CPC分类号： A61K51/0491 ,  A61K51/0497 ,  A61K51/082 ,  A61K51/088 ,  C07B59/004 ,  C07B2200/05 ,  C07F9/5022 ,  C07F13/005 ,  C07H5/06 ,  C07H13/08 ,  C07K5/1013 ,  C07K7/02 ,  C07K7/06 ,  C07K7/64

摘要： This invention relates to novel highly functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals. Also, this invention provides radiopharmaceuticals comprised of highly functionalized phosphine ligated 99mTc labeled HYNIC-conjugated biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer.

公开(公告)号：EP1102777B1

公开(公告)日：2002-12-18

申请号：EP99936818.6

申请日：1999-07-30

申请人： BP Chemicals Limited

发明人： GIBSON, Vernon, Charles ,  McTAVISH, Stuart, James

IPC分类号： C07F13/00 ,  C07F15/00 ,  C07F15/02 ,  C07F15/04

CPC分类号： C07F13/005 ,  C07F15/0053 ,  C07F15/025 ,  C07F15/045

摘要： A process is described for producing a transition metal complex of formula (B) wherein M is Fe[II], Fe[III], Co[I], Co[II], Co[III], Mn[I], Mn[II], Mn[III], Mn[IV], Ru[II], Ru[III] or Ru[IV]; X represents an atom or group covalently or ionically bonded to the transition metal M; T is the oxidation state of the transition metal M and b is the valency of the atom or group X; R , R , R , R , R , R and R are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl; and when any two or more of R - R are hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl, said two or more can be linked to form one or more cyclic substituents; comprising reacting together in a single stage reaction components comprising (1) precursors capable of forming Ligand (B) and (2) a compound of the formula M[T]-(T/b)X. The complex has utility as a catalyst for the polymerisation of 1-olefins.

公开(公告)号：EP1263810A2

公开(公告)日：2002-12-11

申请号：EP01918373.0

申请日：2001-03-07

申请人： E.I. DUPONT DE NEMOURS AND COMPANY

发明人： WANG, Ying ,  ITTEL, Steven, Dale

IPC分类号： C08F10/00 ,  C08F4/622 ,  C08F4/695 ,  C07F7/00 ,  C07F9/00 ,  C07F11/00 ,  C07F13/00

CPC分类号： C08F10/00 ,  C07F7/00 ,  C07F7/006 ,  C07F7/28 ,  C07F9/00 ,  C07F9/005 ,  C07F11/00 ,  C07F11/005 ,  C07F13/00 ,  C07F13/005 ,  C08F110/02 ,  C08F210/16 ,  C08F2500/10 ,  C08F2500/20 ,  C08F210/14 ,  C08F4/69396 ,  C08F4/68396 ,  C08F4/64158 ,  C08F4/60158

摘要： Olefins, such as ethylene, are polymerized using as a polymerization catalyst a complex of a selected transition metal with an anionic ligand that has at least three atoms that may coordinate to the transition metal. Also disclosed are the above selected transition metal complexes, and intermediates thereto.

公开(公告)号：EP0643626B1

公开(公告)日：2002-02-27

申请号：EP92919443.9

申请日：1992-08-26

申请人： Research Corporation Technologies, Inc

发明人： JACOBSEN, Eric, N. ,  ZHANG, Wei ,  DENG, Li

IPC分类号： B01J31/00 ,  C07F9/00 ,  C07F13/00 ,  C07F11/00 ,  C07F15/00 ,  C07D493/00 ,  C07D301/06 ,  C07D301/12 ,  C07D301/14 ,  C07D305/00 ,  C07D493/04 ,  B01J31/18 ,  C07C315/02 ,  C07D305/14 ,  C07D303/48

CPC分类号： B01J31/2243 ,  B01J2231/72 ,  B01J2531/0252 ,  B01J2531/0266 ,  B01J2531/72 ,  C07C315/02 ,  C07D301/12 ,  C07D301/14 ,  C07D305/14 ,  C07D493/04 ,  C07D493/10 ,  C07F13/005

摘要： Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has general structure (I). In accordance with another aspect of the present invention is a method of producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.