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    PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE BETA-HYDROXY- ALPHA-AMINOCARBOXYLIC ACID DERIVATIVES
    61.
    发明公开
    PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE BETA-HYDROXY- ALPHA-AMINOCARBOXYLIC ACID DERIVATIVES 有权
    PROCESS生产光学活性的β-羟基-α-氨基羧酸的衍生物

    公开(公告)号：EP1650185A4

    公开(公告)日：2007-06-20

    申请号：EP04747297

    申请日：2004-07-09

    申请人： NISSAN CHEMICAL IND LTD

    发明人： HAMADA YASUMASA ,  MAKINO KAZUISHI

    IPC分类号： C07C227/32 ,  B01J31/24 ,  C07B53/00 ,  C07C229/22 ,  C07C229/28

    CPC分类号： C07C227/32 ,  B01J31/2404 ,  B01J2531/821 ,  C07B2200/07 ,  C07C229/22

    摘要： [PROBLEMS] To provide a process for efficient production of optically active β-hydroxy-α-aminocarboxylic acid derivatives of anti conformation useful as intermediates of drugs or agricultural chemicals. [MEANS FOR SOLVING PROBLEMS] A process for the production of optically active β-hydroxy-α-aminocarboxylic acid derivatives represented by the general formula (2) or (3): [wherein R1 is substituted or unsubstituted C1-20 alkyl or a substituted or unsubstituted C4-12 aromatic group; and R2 is substituted or unsubstituted C1-20 alkyl or a substituted or unsubstituted C4-12 aromatic group], characterized by hydrogenating an α-aminoacylacetate ester represented by the general formula (1): [wherein R1 and R2 are each as defined above] through catalytic asymmetric hydrogenation in the presence of an acid.

    Method for producing basic amino acid
    66.
    发明公开
    Method for producing basic amino acid 有权
    Verfahren zur Herstellung von basedchenAminosäuren

    公开(公告)号：EP1182261A1

    公开(公告)日：2002-02-27

    申请号：EP01120248.8

    申请日：2001-08-23

    申请人： Ajinomoto Co., Ltd.

    发明人： Kobayashi, Masaki ,  Itoyama, Tsuyoshi ,  Mitani, Yukio ,  Usui, Naoki

    IPC分类号： C12P13/08 ,  C12P13/10 ,  C12P13/24 ,  C12P13/04 ,  C07C229/26 ,  C07C229/28 ,  C07D233/64

    CPC分类号： C12P13/10 ,  C12P13/08 ,  C12P13/24 ,  Y02P20/142

    摘要： When a basic amino acid is produced by culturing a microorganism having an ability to produce the basic amino acid in a liquid medium under an aerobic condition to produce and accumulate the basic amino acid in the medium, pH of the medium is controlled to be 6.5-9.0 during the culture, and 7.2-9.0 at the end of the culture, and a culture period where 2 g/L or more of hydrogencarbonate ions and/or carbonate ions exist in the medium is secured during the culture by controlling pressure in a fermentation tank to be a positive pressure during the fermentation, or supplying carbon dioxide gas or a mixed gas containing carbon dioxide gas to the medium, so that the hydrogencarbonate ions and/or carbonate ions should serve as counter ions of cations mainly consisting of the basic amino acid.

    摘要翻译： 当在需氧条件下培养具有在液体培养基中生产碱性氨基酸的能力的微生物产生碱性氨基酸以在培养基中产生和积累碱性氨基酸时，将培养基的pH控制在6.5- 9.0，在培养结束时为7.2-9.0，培养期间通过控制发酵中的压力确保培养中存在2g / L以上碳酸氢根离子和/或碳酸根离子的培养期 罐在发酵过程中为正压，或向介质供应二氧化碳气体或含二氧化碳气体的混合气体，以使碳酸氢根离子和/或碳酸根离子作为主要由碱性氨基 酸。

    PROCESS FOR THE SYNTHESIS OF 1-(AMINOMETHYL)CYCLOHEXYL-ACETIC ACID
    67.
    发明公开
    PROCESS FOR THE SYNTHESIS OF 1-(AMINOMETHYL)CYCLOHEXYL-ACETIC ACID 有权
    合成1-（氨基甲基）环己基 - 乙酸的方法

    公开(公告)号：EP1140793A1

    公开(公告)日：2001-10-10

    申请号：EP99963652.5

    申请日：1999-12-23

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： GIZUR, Tibor ,  LENGYEL, Zoltánné ,  SZALAI, Krisztina

    IPC分类号： C07C227/04 ,  C07C229/28 ,  C07C205/51

    摘要： The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, benzyl group, diphenylmethyl group or C1-C4 alkyl or alkoxy aromatic ring substituted derivatives thereof.

    摘要翻译： 本发明涉及通过式（II）的新的中间体1-（硝基甲基）环己基 - 乙酸衍生物合成式（I）的1-（氨基甲基）环己基 - 乙酸的新方法，其中R代表氢， 苄基，二苯甲基或其C1-C4烷基或烷氧基芳环取代的衍生物。

    MANGANESE CHELATES WITH HIGH RELAXIVITY IN SERUM
    68.
    发明公开
    MANGANESE CHELATES WITH HIGH RELAXIVITY IN SERUM 有权
    锰在血清中高度放松

    公开(公告)号：EP1061957A1

    公开(公告)日：2000-12-27

    申请号：EP99910336.9

    申请日：1999-03-09

    申请人： BRACCO S.p.A. ,  DIBRA S.p.A.

    发明人： BROCCHETTA, Marino ,  CALABI, Luisella ,  FEDELI, Franco ,  MANFREDI, Giuseppe ,  PALEARI, Lino ,  UGGERI, Fulvio

    IPC分类号： A61K49/00 ,  C07C229/28 ,  C07C229/36 ,  C07C233/83 ,  C07D209/20 ,  C07C229/22

    CPC分类号： A61K49/06 ,  C07C229/36

    摘要： Compounds of formula (I) wherein: R1, R2 which are the same or different, are a hydrogen atom, or a -(CH2)m-O-(CH2)n-R3 group, wherein R3 is an aryl residue, m is an integer 1 to 5 and n is an integer 1 to 4, with the proviso that R1 and R2 cannot be at the same time hydrogen, as well as the optically active forms of the chelates thereof with Mn(II) and the salts thereof with physiologically compatible organic bases selected from primary, secondary, tertiary amines or basic amino acids, or with inorganic bases whose cations are sodium, potassium, magnesium, calcium, or mixtures thereof, are disclosed.

    摘要翻译： 其中：R 1，R 2相同或不同，为氢原子或 - （CH 2）m -O-（CH 2）n -R 3基团的式（I）化合物，其中R 3为芳基，m为整数 1至5，并且n是整数1至4，条件是R 1和R 2不能同时为氢，以及其与Mn（II）螯合物的光学活性形式及其盐与生理相容 公开了选自伯，仲，叔胺或碱性氨基酸的有机碱或其阳离子为钠，钾，镁，钙或其混合物的无机碱。