公开(公告)号：EP1004313A4

公开(公告)日：2005-01-19

申请号：EP98919584

申请日：1998-05-13

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： SATO KOH ,  TSUNENARI TOSHIAKI ,  ISHII KIMIE

IPC分类号： A61K38/00 ,  C07K14/635 ,  C07K16/26 ,  C12N15/13 ,  C12P21/08 ,  A61K38/29 ,  A61K39/395 ,  A61K45/00 ,  C07K16/28 ,  C12P21/02

CPC分类号： C07K14/635 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/24 ,  C07K2319/00

摘要： A cachexia remedy containing an active ingredient comprising a substance inhibiting the binding of a parathyroid hormone-related peptide and a receptor thereof. Examples of the inhibiting substance include antagonists against parathyroid hormone-related peptide receptors, parathyroid hormone-related peptide antibodies, antibody fragments, and modified antibodies.

公开(公告)号：EP0822200B1

公开(公告)日：2004-09-22

申请号：EP97112595.0

申请日：1997-07-23

申请人： F. HOFFMANN-LA ROCHE AG

发明人： Arzeno, Humberto Bartolome

IPC分类号： C07K14/635 ,  C07K1/06

CPC分类号： C07K14/635 ,  A61K38/00 ,  Y02P20/55

公开(公告)号：EP1276856A4

公开(公告)日：2004-06-09

申请号：EP01937179

申请日：2001-04-12

申请人： HUMAN GENOME SCIENCES INC

发明人： ROSEN CRAIG A ,  HASELTINE WILLIAM A

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K38/21 ,  A61K38/22 ,  A61K38/23 ,  A61K38/27 ,  A61K38/28 ,  A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61K38/55 ,  A61K39/395 ,  A61K47/48 ,  A61K48/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P3/14 ,  A61P5/00 ,  A61P5/10 ,  A61P5/14 ,  A61P5/40 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/02 ,  A61P13/08 ,  A61P13/12 ,  A61P15/00 ,  A61P15/08 ,  A61P15/10 ,  A61P15/18 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/12 ,  A61P17/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P33/02 ,  A61P33/06 ,  A61P33/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  A61P39/02 ,  A61P41/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/55 ,  C07K14/56 ,  C07K14/565 ,  C07K14/585 ,  C07K14/60 ,  C07K14/61 ,  C07K14/62 ,  C07K14/635 ,  C07K14/65 ,  C07K14/705 ,  C07K14/715 ,  C07K14/745 ,  C07K14/75 ,  C07K14/76 ,  C07K14/765 ,  C07K14/81 ,  C07K16/00 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/02 ,  C12N5/10 ,  C12N9/14 ,  C12N9/74 ,  C12N9/99 ,  C12N15/62 ,  C07K1/00

CPC分类号： A61K38/4846 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/38 ,  A61K47/42 ,  A61K47/65 ,  A61K48/00 ,  A61K2039/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/65 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/76 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/96 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：EP1114865B1

公开(公告)日：2004-01-21

申请号：EP01107746.8

申请日：1987-10-07

申请人： Allelix Biopharmaceuticals Inc.

发明人： Alestrom, Peter Dr. ,  Gautvik, Kaare M., Dr.

IPC分类号： C12N15/16 ,  C12N15/62 ,  C12N1/21 ,  C12N1/19 ,  C07K14/635

CPC分类号： C07K14/635 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C12N15/64 ,  C12N15/66 ,  C12N15/67 ,  C12N15/70 ,  C12N15/81

公开(公告)号：EP1359932A2

公开(公告)日：2003-11-12

申请号：EP02707496.2

申请日：2002-01-17

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： JÜPPNER, Harald ,  GARDELLA, Thomas, J. ,  JONSSON, Kenneth, P. ,  JOHN, Markus, R. ,  GENSURE, Robert, C.

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/29 ,  C07K14/00 ,  C07K14/435 ,  C07K14/635

CPC分类号： C07K14/635

摘要： The invention relates to truncated TIP39 polypeptides and chimeric PTHrP/TIP polypeptides. The polypeptides are used as agonists or antagonists of PTH receptors in various medical conditions.

公开(公告)号：EP0915911B1

公开(公告)日：2003-10-29

申请号：EP97933603.9

申请日：1997-08-01

申请人： National Research Council of Canada

发明人： BARBIER, Jean-René ,  MORLEY, Paul ,  NEUGEBAUER, Witold ,  WHITFIELD, James ,  WILLICK, Gordon, E.

IPC分类号： C07K14/635

CPC分类号： A61K38/29 ,  C07K14/635

摘要： This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailabilities. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of Lactams between either Glu and Lys or Lys and Asp . In addition, the natural Lys may be substituted by either a Leu or other hydrophobic residues, such as Ile, norleucine, Met, Val, Ala, Trp, or Phe. Typically, these analogues have enhanced abilities to stimulate adenylyl cyclase in rat osteosarcoma cells, and show increased activities in bone restoration, using the ovariectomized rat model. The analogues also show enhanced activities and bioavailabilities, as demonstrated by their hypotensive effects in the rat. An assay which correlates hypotensive activity with osteogenic activity is also described.

公开(公告)号：EP1123401A1

公开(公告)日：2001-08-16

申请号：EP99970686.4

申请日：1999-10-20

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： GARDELLA, Thomas, J. ,  KRONENBERG, Henry, M. ,  POTTS, John, T., Jr. ,  JÜPPNER, Harald

IPC分类号： C12N15/16 ,  C07K14/635 ,  A61K38/29 ,  C12P21/02 ,  C12N1/19 ,  C12N1/21 ,  C12N5/16 ,  C12N5/14

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/635

摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.

公开(公告)号：EP1093458A4

公开(公告)日：2001-07-18

申请号：EP99917595

申请日：1999-04-15

申请人： AVENTIS PHARM PROD INC

发明人： SLEDESKI ADAM W ,  MENCEL JAMES J

IPC分类号： C07K17/08 ,  C07K1/04 ,  C07K5/062 ,  C07K5/078 ,  C07K5/09 ,  C07K5/113 ,  C07K7/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07K14/635

CPC分类号： C07K5/06182 ,  C07K1/04 ,  C07K7/54 ,  C07K14/635

摘要： This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one bridge between the side chains of two non-adjacent amino acid residues, and to peptide fragments useful therefor.

摘要翻译： 本发明涉及用于甲状旁腺激素的树脂结合环肽类似物和甲状旁腺激素相关蛋白类似物的固相片段合成方法，所述类似物在两个非甲状腺激素的侧链之间含有至少一个桥， 相邻的氨基酸残基，以及用于其的肽片段。

公开(公告)号：EP1016723A1

公开(公告)日：2000-07-05

申请号：EP99310191.4

申请日：1999-12-17

申请人： ELI LILLY AND COMPANY

发明人： Hale, John Edward ,  Hershberger, Charles Lee ,  Larson, Jeffrey Lynn ,  Menke, Michael Andrew

IPC分类号： C12N15/57 ,  C12N9/48 ,  C12N15/16 ,  C07K14/67 ,  C07K14/635 ,  C07K14/605 ,  C12N15/62 ,  C07K19/00

CPC分类号： C12N9/48 ,  C07K14/605 ,  C07K14/635 ,  C07K14/67 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids, vectors, transformed host cells, fusion proteins, and recombinant methods for producing proteins using the propeptide sequence of procarboxypeptidase B.

摘要翻译： 本发明提供分离的核酸，载体，转化的宿主细胞，融合蛋白，以及使用前羧肽酶B的前肽序列产生蛋白质的重组方法。

公开(公告)号：EP0892644A4

公开(公告)日：1999-07-14

申请号：EP97922578

申请日：1997-04-11

申请人： UNIV MICHIGAN

发明人： GOLDSTEIN STEVEN A

IPC分类号： A61K47/02 ,  A61K9/00 ,  A61K38/00 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/22 ,  A61K38/29 ,  A61K47/42 ,  A61K47/48 ,  A61K48/00 ,  A61L17/00 ,  A61L27/00 ,  A61P17/02 ,  A61P17/06 ,  A61P43/00 ,  C07K14/47 ,  C07K14/51 ,  C07K14/635 ,  C07K14/72 ,  C07K14/78 ,  C12N15/12 ,  C12N15/87

CPC分类号： A61K9/0024 ,  A61K38/00 ,  A61K47/6953 ,  A61K48/00 ,  C07K14/47 ,  C07K14/51 ,  C07K14/635 ,  C07K14/72 ,  C07K14/78 ,  C07K2319/00 ,  C12N15/87 ,  C12N2799/022