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公开(公告)号：EP1333032A1
公开(公告)日：2003-08-06
申请号：EP01974669.2
申请日：2001-10-03
发明人： SHINKAWA, Toyohide, c/o Kyowa Hakko Kogyo Co.,Ltd. , UCHIDA, Kazuhisa, c/o Kyowa Hakko Kogyo Co.,Ltd. , YAMASAKI, Motoo, c/o Kyowa Hakko Kogyo Co.,Ltd. , HOSAKA, Emi, c/o Kyowa Hakko Kogyo Co.,Ltd. , SHITARA, Kenya, c/o Kyowa Hakko Kogyo Co., Ltd.
IPC分类号： C07K1/22 , C07K16/28 , A61K39/395 , A61K45/00 , G01N33/531
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/065 , C07K2317/24 , C07K2317/732
摘要： The present invention relates to a process for purifying an antibody having a desired property, which comprises using a substance having an affinity to a carbohydrate binding to the antibody; a medicament comprising, as an active ingredient, the antibody purified by the process; and a method for diagnosing or preventing various diseases, which comprises using a substance having an affinity to a carbohydrate binding to an antibody.
摘要翻译： 本发明涉及一种纯化具有所需性质的抗体的方法，其包括使用与结合抗体的碳水化合物具有亲和性的物质; 一种药物，其包含通过该方法纯化的抗体作为活性成分; 以及用于诊断或预防各种疾病的方法，其包括使用与结合抗体的碳水化合物具有亲和力的物质。
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公开(公告)号：EP0508472B1
公开(公告)日：2003-07-09
申请号：EP92106282.4
申请日：1992-04-10
发明人： Fujiwara, Katsumi , Shitara, Kenya , Ohta, So , Hanai, Nobuo
IPC分类号： C12N5/16 , C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , C07K2317/734 , C12N5/163 , C12N2510/02
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公开(公告)号：EP1323732A1
公开(公告)日：2003-07-02
申请号：EP01970148.1
申请日：2001-09-19
发明人： AKIYAMA, Tetsu , ADACHI, Shungo
IPC分类号： C07K14/435 , C12N15/12 , C12N5/18 , C12Q1/68 , A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： C07K14/4705 , A01K2217/05 , A01K2217/075 , A61K38/00 , G01N33/57484 , G01N33/57496
摘要： The present invention provides a novel β-catenin nuclear localizing protein and DNA encoding the protein. Furthermore, the use of the β-catenin nuclear localizing protein and the DNA encoding the protein provides a diagnostic agent and therapeutic agent for diseases such as cancer which is related to nuclear localization of β-catenin.
摘要翻译： 本发明提供了一种新的β-连环蛋白核定位蛋白和编码该蛋白的DNA。 此外，β-连环蛋白核定位蛋白和编码该蛋白质的DNA的使用为与β-连环蛋白的核定位相关的癌症等疾病提供诊断剂和治疗剂。
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74.发明公开METHOD OF COATING FINE PARTICLE WITH LIPID FILM 有权方法ZUR BESCHICHTUNG FEINER TEILCHEN MIT EINEM LIPIDFILM
公开(公告)号：EP1323415A1
公开(公告)日：2003-07-02
申请号：EP01974690.8
申请日：2001-10-04
发明人： KATO, Yasuki, c/o Pharmaceutical Research Inst. , YAMAUCHI, Masahiro, c/o Pharmaceutical Res. Ins , KUSANO, Hiroko, c/o Pharmaceutical Research Inst. , IWATA, Takeshi, c/o Pharmaceutical Research Inst. , UOCHI, Takaaki, c/o Pharmaceutical Research Inst. , AKINAGA, Shiro, c/o KYOWA HAKKO KOGYO CO., LTD
IPC分类号： A61K9/127 , A61K47/24 , A61K47/44 , A61K31/711 , A61K31/70 , A61K31/74 , A61K48/00 , A61K38/02 , B01J13/12
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/141 , A61K9/146 , A61K9/5015 , A61K9/5192 , A61K31/7088 , A61K47/6911 , B01J13/12
摘要： An object of the present invention is to provide a safe, convenient and efficient method for coating fine particles with lipid membrane.
There is provided a method for coating fine particles with lipid membrane, characterized in that, the rate of a polar organic solvent in an aqueous solution containing the polar organic solvent where the fine particles are dispersed and lipid is dissolved, is decreased.摘要翻译： 本发明的目的是提供一种安全，方便和有效的用脂质膜涂覆微粒的方法。 提供了一种用脂质膜涂覆微粒的方法，其特征在于，含有分散有微粒的极性有机溶剂的水溶液中的极性有机溶剂的比例和脂质被溶解。
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公开(公告)号：EP0950664B1
公开(公告)日：2003-07-02
申请号：EP99107190.3
申请日：1999-04-13
IPC分类号： C07K5/06 , C07C233/47
CPC分类号： C07K5/06026 , C07C233/47
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公开(公告)号：EP1316608A1
公开(公告)日：2003-06-04
申请号：EP01963410.4
申请日：2001-08-31
发明人： NARIMATSU, Hisashi , SASAKI, Katsutoshi c/o Tokyo Research Laboratories , NATSUME, Ayumi c/o Tokyo Research Laboratories , MIO, Hiroyuki c/o Kyowa Hakko Kogyo Co., Ltd. , NAKAGAWA, Satoshi , SEKINE, Susumu c/o Tokyo Research Laboratories , TOGAYACHI, Akira
CPC分类号： C12N9/1051 , A01K2217/05 , A01K2217/075 , C07K2319/00 , C12N9/1241 , C12N2799/026 , C12Y204/0108
摘要： The present invention provides a novel polypeptide having a β1, 3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar chain, DNA encoding the polypeptide, a process for producing the polypeptide, an antibody against the polypeptide, and a diagnosis method and a medicament for treatment for inflammation, cancer or tumor metastasis using the DNA or the antibody. The present invention is useful for synthesis of a useful sugar chain and diagnosis and treatment for inflammatory diseases, cancer or tumor metastasis.
摘要翻译： 本发明提供一种具有β1,3-N-乙酰氨基葡糖基转移酶活性的新型多肽，用于合成包含该多肽的糖链的试剂，使用该糖合成试剂制备糖链或复合碳水化合物的方法， 编码多肽的DNA，产生多肽的方法，针对多肽的抗体，以及诊断方法和用于使用DNA或抗体治疗炎症，癌症或肿瘤转移的药物。 本发明可用于合成有用的糖链，并用于炎性疾病，癌症或肿瘤转移的诊断和治疗。
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公开(公告)号：EP0694614B1
公开(公告)日：2003-06-04
申请号：EP95110186.4
申请日：1995-06-29
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公开(公告)号：EP1044203B1
公开(公告)日：2003-03-12
申请号：EP98964309.3
申请日：1998-12-30
IPC分类号： C07D498/22 , A61K31/55 , C07H7/06
CPC分类号： C07D498/22 , C07H5/06
摘要： Compounds defined by general structure (II) are disclosed. These compounds display pharmacological activities, including inhibition of tyrosine kinase activity and enhancement of the function and/or survival of trophic factor responsive cells, e.g., cholinergic neurons.
摘要翻译： 公开了由通式结构（II）定义的化合物。 这些化合物显示出药理学活性，包括抑制酪氨酸激酶活性和增强营养因子应答细胞（例如胆碱能神经元）的功能和/或存活。
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公开(公告)号：EP1283255A1
公开(公告)日：2003-02-12
申请号：EP01926026.4
申请日：2001-04-27
发明人： YAMADA, Yoji , SEKINE, Susumu , KIKUCHI, Yasuhiro, Kyowa Hakko Kogyo Co. Ltd. , SAKURADA, Kazuhiro
IPC分类号： C12N1/15 , C12N1/19 , C12N5/00 , C12N7/00 , C12N15/00 , C12P21/02 , C12Q1/68 , C07K14/47 , C07K16/18
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/475 , C07K16/18 , C12Q2600/158
摘要： Genes showing different expression levels between fetal heart and adult heart were obtained. Thus, proteins useful in searching for therapeutic agents for repairing tissues injured by myocardial degeneration, DNAs encoding these proteins, antibodies recognizing these proteins, and methods of using the same are provided.
摘要翻译： 获得显示胎儿心脏和成人心脏之间不同表达水平的基因。 因此，提供了用于寻找治疗剂以修复心肌变性损伤组织的蛋白质，编码这些蛋白质的DNA，识别这些蛋白质的抗体，以及使用它们的方法。
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80.发明公开PROCESS FOR PRODUCING L-AMINO ACID VIA FERMENTATION METHOD 审中-公开VERFAHREN ZUR HERSTELLUNG EINER L-AMINOSÄUREDURCH EIN FERMENTATIONSVERFAHREN
公开(公告)号：EP1275729A1
公开(公告)日：2003-01-15
申请号：EP01915731.2
申请日：2001-03-23
发明人： IKEDA, Masato, c/o Tokyo Research Laboratories , YAGASAKI, Makoto, c/o Technical Res. Laborator , TAKANO, Jun-Ichi, c/o Hofu Plant , ABE, Yayoi, c/o Technical Research Laboratories
CPC分类号： C12N9/1096 , C12P13/04 , C12P13/06
摘要： According to the present invention, by using a microorganism having the ability to produce the L-amino acid which carries the avt A gene encoding alanine-valine transaminase (transaminase C) and whose alanine-valine transaminase activity is enhanced compared with its parent strain, it is possible to reduce the production of by-product amino acids which disturb purification in L-amino acid production by fermentation, and an industrially advantageous process for producing an L-amino acid can be provided.
摘要翻译： 根据本发明，通过使用具有产生携带编码丙氨酸 - 缬氨酸转氨酶（转氨酶C）的avtA基因的L-氨基酸并且与其亲本菌株相比其丙氨酸 - 缬氨酸转氨酶活性增强的能力的微生物， 可以减少通过发酵干扰L-氨基酸生产中的纯化的副产物氨基酸的生产，并且可以提供用于生产L-氨基酸的工业上有利的方法。
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