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公开(公告)号：EP0811013A1
公开(公告)日：1997-12-10
申请号：EP96906281.0
申请日：1996-02-01
发明人： BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , DE PLAEN, Etienne , LURQUIN, Christoph , GAUGLER, Beatrice , VAN DEN EYNDE, Benoit , TRAVERSARI, Catia , ROMERO, Pedro
IPC分类号： G01N33 , A61K38 , A61K39 , A61P35 , A61P37 , C07K7 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention involves nonapeptides by HLA molecules such as HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.
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72.发明公开ISOLATED PEPTIDES DERIVED FROM MAGE TUMOR REJECTION ANTIGEN PRECURSORS WHICH COMPLEX WITH HLA-A2 MOLECULES 失效衍生自与HLA-A2分子复合的肿瘤抑制性抗原前体的分离肽
公开(公告)号：EP0804483A1
公开(公告)日：1997-11-05
申请号：EP95914838.0
申请日：1995-03-22
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , RIJKSUNIVERSITEIT LEIDEN
发明人： TOWNSEND, Alan Molecular Immunology Group , BASTIN, Judy Molecular Immunology Group , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierrce , COULIE, Pierre , GAJEWSKI, Thomas , MELIEF, Cornelis J.M. , VISSEREN, M.W. , KAST, W.M.
IPC分类号： G01N33 , A61K35 , A61K38 , A61K39 , A61P35 , A61P37 , C07K7 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21
CPC分类号： C07K14/4748 , A61K38/00
摘要： Tumor rejection antigens derived from MAGE tumor rejection precursors have been identified. These 'TRAS' bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
摘要翻译： 已经鉴定出来自MAGE肿瘤排斥前体的肿瘤排斥抗原。 这些'TRAS'与MHC I类分子HLA-A2结合，并且所得到的复合物刺激裂解呈递细胞的溶细胞T细胞克隆的产生。 肽和复合物可以在诊断上，治疗上以及用于产生抗体的免疫原或用作产生溶细胞T细胞克隆的靶标。
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73.发明公开ISOLATED, TRUNCATED NUCLEIC ACID MOLECULES WHICH CODE FOR GAGE TUMOR REJECTION ANTIGEN 失效隔离和浓缩核酸分子编码GAGE TUMORABSTOSSUNGSANTIGEN
公开(公告)号：EP0804467A1
公开(公告)日：1997-11-05
申请号：EP96905135.0
申请日：1996-01-11
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
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74.发明公开
公开(公告)号：EP0789591A1
公开(公告)日：1997-08-20
申请号：EP95913476.0
申请日：1995-01-26
发明人： VAN DER BRUGGEN, Pierre , SZIKORA, Jean-Pierre , COULIE, Pierre , WILDMANN, Claude , BOEL, Pascale , BOON-FALLEUR, Thierry
IPC分类号： G01N33 , A61K35 , A61K38 , A61K39 , A61P35 , C07K7 , C07K14 , C12N5 , C12N15 , C12Q1 , A61K48
CPC分类号： G01N33/5011 , A61K35/17 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/70539 , G01N2333/70539 , G01N2800/52
摘要： This invention relates to MAGE-1 derived nonapeptides. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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75.发明公开COMPOSITIONS CONTAINING TUMOR REJECTION ANTIGEN PRECURSORS OR TUMOR REJECTION ANTIGENS, AND AN ADJUVANT AND/OR GROWTH FACTOR 失效组合物，其肿瘤抗原不一致PRE-或肿瘤抗原可恶包含佐剂和/或生长因子的
公开(公告)号：EP0782453A1
公开(公告)日：1997-07-09
申请号：EP95938112.0
申请日：1995-09-27
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5555 , A61K2039/55577 , C07K14/4748
摘要： Compositions with improved immunogenic effect are disclosed. The compositions contain one or more peptides which, when complexed with a cell surface molecule, such as an MHC, HLA or B cell receptor, provoke an immune response. The compositions contain adjuvants such as saponins, which potentiate the immune response. Especially preferred are compositions which stimulate cytolytic T cell responses, such as peptides which satisfy criteria for MHC binding, such as peptides derived from tumor rejection antigen precursors, including MAGE, BAGE, and GAGE derived peptides.
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76.发明公开METHOD FOR PRODUCING CYTOLYTIC T CELLS SPECIFIC FOR A COMPLEX OF PEPTIDE AND MHC-MOLECULE 失效用于生产细胞毒性T细胞特异性复合体的肽与MHC分子
公开(公告)号：EP0767911A1
公开(公告)日：1997-04-16
申请号：EP95923868.0
申请日：1995-06-14
CPC分类号： G01N33/56977 , A61K2039/5158 , C12N5/0636 , C12N2500/32 , C12N2501/23 , C12N2502/11
摘要： This invention relates to methods of obtaining cytolytic T cell subpopulations specific for a peptide/MHC complex.
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77.发明公开METHODS FOR DETECTION AND TREATMENT OF INDIVIDUALS HAVING ABNORMAL CELLS EXPRESSING HLA-A2/TYROSINASE PEPTIDE ANTIGENS 失效方法的检测和治疗具有异常HLA-A2 /酪氨酸酶肽抗原表达细胞的个体
公开(公告)号：EP0687180A1
公开(公告)日：1995-12-20
申请号：EP94905393.0
申请日：1993-12-14
发明人： BOON-FALLEUR, Thierry , BRICHARD, Vincent , VAN PEL, Aline , DE PLAEN, Etienne , COULIE, Pierre , RENAULD, Jean-Christophe , WOLFEL, Thomas , LETHE, Bernard
IPC分类号： C12N15 , A61K35 , A61K38 , A61K49 , A61P43 , C07K7 , C07K14 , C07K16 , C12N5 , C12N9 , C12Q1 , G01N33 , A61K39 , A61K48
CPC分类号： G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/535 , C07K16/243 , C12N9/0071 , C12Y114/18001 , G01N33/505 , Y10S436/813 , Y10S514/885 , Y10S530/828
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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78.发明公开ISOLATED NONAPEPTIDE DERIVED FROM MAGE-3 GENE AND PRESENTED BY HLA-A1, AND USES THEREOF 失效从MAGE-3基因的和HLA-A1-提出，隔离九肽及其应用。
公开(公告)号：EP0658113A1
公开(公告)日：1995-06-21
申请号：EP93920419.0
申请日：1993-08-30
发明人： BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , DE PLAEN, Etienne , LURQUIN, Christophe , TRAVERSARI, Catia
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention involves a nonapeptide derived from the tumor rejection antigen precursor encoded by gene MAGE-3. This nonapeptide is presented by HLA molecules HLA-A1. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.
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